Twins vs. Cubs Prediction, MLB Picks for Saturday, July 18

The Minnesota Twins vs. Chicago Cubs game is scheduled to get underway at 2:20 p.m. ET on Saturday, July 18, with the Cubs favored and returning a 1.66x payout if they come out on top, per PrizePicks.

Minnesota got the series started on the right foot with a 5-2 win against Chicago on Friday evening. Twins C Ryan Jeffers broke a 1-1 tie with a 3-run home run in the third inning, and Minnesota never looked back. 

Below, we'll break down our Twins vs. Cubs prediction and picks for Saturday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.

Make your Twins vs. Cubs picks and predictions on PrizePicks now.

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Twins vs. Cubs Prediction, Winner Payout, Over/Under – Saturday, July 18

The Twins have proven to have the Cubs’ number in recent meetings between the two teams. Minnesota has won three of the last four contests, including Friday’s triumph. During those victories, the Twins have won all three games by at least a pair of runs.

Minnesota sends SP Taj Bradley to the mound for Saturday’s matinee against Chicago. Bradley has been sensational lately, tallying a 1.89 ERA across his last three starts. In addition, the right-hander has won all three of those outings.

Meanwhile, SP Matthew Boyd will be on the hill for the Cubs on Saturday. The veteran left-hander suffered a left meniscus injury in May and missed nearly two months of action. Boyd is coming off a start in which he surrendered 4 earned runs across 6.1 innings against the Cincinnati Reds.

Offensively, the Cubs and Twins have been two of the top lineups around the majors this season. According to FanGraphs, Chicago has the third-best wRC+ (109), while Minnesota ranks sixth with a wRC+ of 106.

Both teams are also fairly disciplined at the dish, with the Twins owning a 21.6% strikeout rate (17th) and the Cubs ranking 21st with a 21.4% K-rate. 

Twins vs. Cubs Winner Payout, Over/Under – Saturday, July 18

The Cubs enter Saturday's game as a home favorite against the Twins, returning a 1.66x payout if they win outright via PrizePicks Team Picks.

Here are the full payouts for the Twins vs. Cubs game on PrizePicks.

• Spread: Chicago Cubs -1.5 (2.38x payout)
• Over/Under: 8.5 (1.72x payout on Over)
• Game Winner Payout: Twins 2.12x | Cubs 1.66x

Play the Twins vs. Cubs winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Twins vs. Cubs Prediction on Winner – 7/18/26

Here are the key game stats and trends behind our Twins vs. Cubs prediction on the winner for Saturday, July 18.

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• The Twins are 6-3 against the Cubs in their last nine meetings.
• According to Baseball Savant, Bradley has produced a 27.4% strikeout rate, which ranks in the 81st percentile.
• The veteran right-hander has yielded 2 or fewer runs in each of his last five starts before the All-Star break. In addition, the Twins have won all five of those outings.
• Boyd has recorded a 4.90 expected ERA (xERA), ranking in just the 22nd percentile, and has allowed at least 4 runs in three of his nine starts in 2026.
• From an offensive standpoint, these two teams are very evenly matched. The Cubs sit fifth in runs (484), but the Twins are right on their heels in sixth (471).
• Minnesota has racked up a 7-2 record across its last nine games, including winning all three road outings during that stretch. 

Twins vs. Cubs Picks, Player Stats for PrizePicks: 7/18/26

Here are the top Twins vs. Cubs picks to target on Saturday, July 18. Today’s MLB picks for PrizePicks include OF Seiya Suzuki and 1B Josh Bell.

Cubs OF Seiya Suzuki vs. Twins: 1.5 Hits + Runs + RBI

• Suzuki is hitting .400 (8-for-20) with 1 home run, 6 RBI, and 4 runs in his last five games.
• The Cubs’ veteran outfielder has scored a run in four contests during that span.
• Suzuki has exhibited tremendous discipline at the plate, recording a 23.0% chase rate that slots into the 87th percentile.
• The Chicago OF has tallied 34 of his 48 RBI against right-handed pitching.

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Twins 1B Josh Bell vs. Cubs: 0.5 Singles

• Bell is hitting .259 (7-for-27) with at least a hit in five of his last seven contests.
• The Twins first baseman has recorded 4 singles during that span, including a game with a pair of them against the Cleveland Guardians on July 7.
• The veteran slugger has produced a .264/.317/.400 slash line against left-handed pitching.
• Bell has tallied a 10.6% barrel rate, which ranks in the 66th percentile.

Add Josh Bell to your PrizePicks Lineup now.

Make Twins vs. Cubs Picks on PrizePicks

The Twins got the better of the Cubs in Friday’s series opener, coming away with a 5-2 victory. With one of its top arms on the mound in SP Taj Bradley, there’s reason to believe that Minnesota might just be able to land in the win column once again. 

Don’t wait until first pitch — make your Twins vs. Cubs picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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