Twins vs. Athletics is set for first pitch at 9:05 p.m. ET on Wednesday, August 26, with the Twins favored and returning a 1.66x payout if they win, via PrizePicks.
The Twins will try to win the rubber match of this series with SP Connor Prielipp (3-7, 5.57 ERA) on the mound. The Athletics will counter with SP J.T. Ginn (8-8, 3.60 ERA), who has given up at least 3 runs in each of his last four outings.
Below, we’ll break down our Twins vs. Athletics prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
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Twins vs. Athletics Prediction, Winner Payout, Over/Under – Wednesday, August 26
The Athletics are currently missing four key hitters with 1B Nick Kurtz (thumb), C Shea Langeliers (knee), 1B/OF Tyler Soderstrom (hip), and OF Brent Rooker (knee) all on the injured list. Their absences have contributed to the team ranking 26th in wRC+ (94).
Combine that with a team xERA of 4.48 that ranks 23rd, and the result is an ugly -188 run differential.
The Twins have also struggled in the pitching department with their 4.30 xERA. However, they have the eighth highest wRC+ (103) in all of baseball. They do a good job making contact, posting the seventh lowest strikeout rate (21.2%) overall.
Twins vs. Athletics Winner Payout, Over/Under – Wednesday, August 26
The Twins enter Wednesday’s game as a road favorite against the Athletics, returning a 1.66x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Twins vs. Athletics game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!
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Team Picks data is live as of writing and is subject to change.
Twins vs. Athletics Prediction on Winner – 8/26/26
Here are the key game stats and trends behind our Twins vs. Athletics prediction on the winner for Wednesday, August 26.
- With injuries piling up, the Athletics are 7-19 over their last 26 games.
- The A’s are 24-41 at home, posting a staggering 1.66 WHIP there.
- The Athletics’ pitching staff only has a 20.3% strikeout rate at home while also posting a 10.4% walk rate, per FanGraphs.
- Although left-handed pitchers have limited the Twins to a .694 OPS, they have a .736 OPS against righties.
- Ginn’s strikeout rate has fallen from 25.3% last season to 21.3% this year. His walk rate, meanwhile, has increased from 7.9% to 9.9%.
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Twins vs. Athletics Picks, Player Stats for PrizePicks: 8/26/26
Here are top Twins vs. Athletics picks to target on Wednesday, August 26. Today's MLB picks for PrizePicks include 3B Zack Gelof and SS Kaelen Culpepper.
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Athletics 3B Zack Gelof vs. Twins: 5.5 Hitter Fantasy Score
- Gelof already has 14 home runs despite being limited to 82 games because of injuries. His career high for home runs in a season is 17, which he slugged over 138 games in 2024.
- Prielipp allowed at least 1 home run in five of his last six starts.
- The Twins’ young lefty has a 1.71 WHIP on the road compared to a 1.17 WHIP at home.
- Gelof has a .401 wOBA and a .264 ISO at home versus respective marks of .267 and .121 on the road.
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Twins SS Kaelen Culpepper vs. Athletics: 1.5 Hits + Runs + RBI
- Culpepper showed a selective eye at the plate in Triple-A, recording an 18.7% strikeout rate and an 11.4% walk rate this year. That helped him record a .376 wOBA to go along with his .207 ISO.
- The young shortstop had a .181 ISO and a .393 wOBA across two levels in the minors last year.
- Culpepper has continued to stay hot since being called up to the majors, batting .333 with a .372 wOBA over 15 games.
- Across his last seven outings, the 23-year-old combined for at least 2 combined hits, runs, and RBI five times.
- Ginn has a 4.70 xFIP and a 1.44 WHIP at home versus a 3.83 xFIP and a 1.06 WHIP on the road.
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The Twins have the potential to slug their way to a win in the third game of their series with the Athletics. Culpepper aims to exploit a favorable matchup against Ginn, who's struggled at home. On the A’s side of things, Gelof could also thrive at the plate in his hitter-friendly park.
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