Top MLB Home Run Picks Today on PrizePicks – Saturday, July 25

The Saturday MLB slate presents a staggering 15-matchup schedule for fans to enjoy. With there being plenty of activity from the afternoon into the night, how many home runs could be hit across the sport? 

Here at PrizePicks, we have plenty of home run projections on the board to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.

Let’s dive into some of the most-picked MLB home run projections for Saturday, July 25, including what makes each player a potential target for home run predictions. 

Make your MLB home run picks for Saturday, July 25 on PrizePicks now.  

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Top Home Run Picks Today – Saturday, July 25

Despite how easy this month’s Home Run Derby made it look during All-Star week, swatting a ball out of the park is no simple feat. Players must control what they can on their end, such as bat speed, swing path, barrel quality, and overall strength, but there are also factors that are out of their control.

First and foremost is the matchup with an opposing pitcher. Does said hurler put more spin on the ball and induce ground balls? What about the outfield dimensions of the ballpark? Is the weather working for or against hitters when it comes to the long ball? All of this and more must be considered, making MLB home run predictions multifaceted in nature. 

Which players could be in good positions to swat a homer on Saturday? Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. With that said, home runs can only be selected as “More” than 0.5. 

Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at time of writing.

1. Astros DH Yordan Alvarez
2. Rockies C Hunter Goodman
3. Cardinals RF Jordan Walker
4. Orioles 1B Pete Alonso
5. White Sox SS Colson Montgomery
6. Giants 1B Rafael Devers
7. Angels CF Mike Trout
8. Padres 3B Manny Machado

Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

Cardinals RF Jordan Walker

Reds vs. Cardinals – 2:15 p.m. ET

Reds Starting Pitcher: Andrew Abbott

MLB Weather Report: 89 degrees, clear skies, 3 mph south-southeast wind

• The Home Run Derby champ is posting a career-best .514 SLG, in addition to a sparkling .226 ISO and 137 wRC+ in 101 games.
• It shouldn’t come as a surprise that Walker is pacing for well over 30 home runs, as his launch angle (11.0 degrees) and barrel rate (14.0%) are seasonal highs for him.
• Walker swings the bat at a blistering pace; his 79.2 mph average bat speed ranks in the 100th percentile. That, paired with an 85.7% fast-swing clip, makes him dangerous.
• After posting a 6.9% line drive rate in 2024, Walker improved it to 13.9% last year and 20.3% in 2026.
• Abbott is nothing to write home about in the loud contact department, evidenced by his barrel rate (7.3%) and hard-hit rate (38.5%) induced ranking in the respective 52nd and 50th percentiles. 

Add Jordan Walker to your PrizePicks Lineup now.

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Giants 1B Rafael Devers

Angels vs. Giants – 4:05 p.m. ET

Angels Starting Pitcher: Ryan Johnson

MLB Weather Report: 65 degrees, clear skies, 1 mph west-southwest wind

• The slugging first baseman is tracking for 25+ home runs for the sixth straight year. His ISO in that span is .236, slightly above his career mark of .231. 
• Devers has a massive L/R split this year, posting a .283 SLG and 49 wRC+ against lefties compared to a .568 SLG and 145 wRC+ vs. right-handed hurlers. 
• The veteran infielder is maximizing his contact; his 33.6% squared-up contact split is the highest it’s ever been in three years of tracking.
• Devers connects firmly with the ball, backed up by a 92.3 mph average exit velo and a 50.7% hard-hit clip that rank in the 89th and 91st percentiles. 
• Johnson is struggling with the long ball in his 38.1 innings pitched, owning a 2.35 HR/9 that could be propped up by a middling sinker (7 HR, .800 SLG). 

Add Rafael Devers to your PrizePicks Lineup now.

Padres 3B Manny Machado

Padres vs. Marlins – 4:10 p.m. ET

Marlins Starting Pitcher: Eury Perez

MLB Weather Report: Played in a dome

• A whopping 18 of Machado’s 22 home runs have come against right-handed pitching in 2026.
• Since a brutal month of May that saw him own a 44 wRC+ and .196 ISO, the star infielder is producing to the tune of a 130 wRC+ and .271 ISO.
• Machado’s .221 ISO is his best since a 32-homer 2022 campaign. That’s despite a .211 BABIP that’s easily the worst of his career. 
• Despite some decline, the 34-year-old’s 74.6 mph bat speed still slots into the 77th percentile.
• Perez is getting hit around thus far in 2026, ceding a 12.1% barrel rate that occupies just the fifth percentile. 

Add Manny Machado to your PrizePicks Lineup now.

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There very well could be double-digit home runs hit during Saturday’s MLB action. Given the favorable conditions they’re playing in this weekend, perhaps the trio of Walker, Devers, and Machado can take advantage and go yard by the time the day is done. 

Don’t wait until first pitch — make your MLB home run picks on PrizePicks now and earn real money if you’re right.

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