Tigers vs. Yankees Prediction, MLB Picks for Monday, June 29

Tigers vs. Yankees is set for first pitch at 7:05 p.m. ET on Monday, June 29, with the Yankees favored on PrizePicks Team Picks and returning a 1.63x payout with a win to kick off the week.

Coming off an embarrassing four-game sweep at the hands of the Red Sox in Boston, the Yankees will return home with SP Ryan Weathers (3-5, 3.95 ERA) on the mound. The Tigers will counter with SP Casey Mize (2-5, 2.95 ERA), who will face the Yankees for the second time in as many starts.

Below, we’ll break down our Tigers vs. Yankees prediction and picks for Monday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Tigers vs. Yankees Prediction, Winner Payout, Over/Under – Monday, June 29

The Yankees have lost four straight games to fall into second place in the AL East. They're 3-7 over their last 10 games, with seven of those matchups coming on the road. They sit at 26-20 on the road this year, compared to 22-15 at home.

One of the main reasons why the Yankees are struggling is that their lineup has gone cold, as it's scored 4 or fewer runs in nine straight games. Even with that factored in, they've still scored the seventh-most runs in baseball. That’s a significant stat in this series, because the Tigers are 22nd in that category.

The big difference between these teams at the plate is the Yankees lead baseball in home runs (121). Detroit ranks 16th (95).

Tigers vs. Yankees Winner Payout, Over/Under – Monday, June 29

The Yankees enter Monday’s game as a home favorite against the Tigers, returning a 1.63x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Tigers vs. Yankees game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

• Spread: New York Yankees -1.5 (2.32x payout)
• Over/Under: 7.5 runs (1.81x payout Over)
• Game Winner Payout: Tigers 2.12x | Yankees 1.63x

Make your Tigers vs. Yankees prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live as of writing and is subject to change.

Tigers vs. Yankees Prediction on Winner – 6/29/26

Here are the key game stats and trends behind our Tigers vs. Yankees prediction on the winner for Monday, June 29.

• The Tigers are 23-21 at home but just 12-28 on the road. No other team in baseball has fewer than 15 wins away from home.
• Detroit has a .695 OPS on the road. Meanwhile, the Yankees have registered an .810 OPS in the confines of Yankee Stadium.
• The Tigers scored 3 or fewer runs in seven of their last 11 road games.
• New York’s pitching staff allows the lowest hard-hit rate in baseball (30.1%), per FanGraphs. The Tigers are 12th (33.3%) in hard-hit rate allowed.
• Weathers gave up 1 or no earned runs in five of his nine starts at home. Overall, he has a 1.12 WHIP at Yankee Stadium.

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Tigers vs. Yankees Picks, Player Stats for PrizePicks: 6/29/26

Here are top Tigers vs. Yankees picks to target on Monday, June 29. Today's MLB picks for PrizePicks include OF Cody Bellinger and SP Casey Mize.

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Yankees OF Cody Bellinger vs. Tigers: 5.5 Hitter Fantasy Score

• Bellinger is coming off a cold road trip in which he hit 2-for-23 (.087) with a .250 OBP across seven games.
• The outfielder hasn't hit well on the road for much of the season, posting a 64 wRC+ away from Yankee Stadium. With that said, he has a 207 wRC+ at home.
• Bellinger is slugging .680 at home compared to .271 on the road.
• Mize has a sparkling 0.91 WHIP at home, but that number rises to 1.29 on the road. Three of the 4 home runs that he's allowed this season have come away from home.

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Tigers SP Casey Mize vs. Yankees: 5 Strikeouts

• Mize has a 25.1% strikeout rate, which is on pace to be the highest mark of his career.
• After throwing his slider only 16.3% of the time last season, it has accounted for 25.1% of his pitches this season, per Baseball Savant. The righty hurler has a 32.3% whiff rate on that offering in 2026.
• The Yankees have the seventh-highest team strikeout rate (23.3%) in the majors.
• Despite giving up 4 runs against the Yankees in his last start, Mize posted 6 strikeouts across 5.2 innings.

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Make Tigers vs. Yankees Picks on PrizePicks

Following a disappointing road trip, the Yankees return home for a series against the Tigers. Bellinger will try to continue his dominance at Yankee Stadium, while Mize aims to exploit the Yankees’ recent inability to make contact.

Don’t wait until the first pitch — make your Tigers vs. Yankees picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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