Tigers vs. Cubs Prediction, MLB Picks for Wednesday, July 22

Tigers vs. Cubs is set for first pitch at 8 p.m. ET on Wednesday, July 22 on ESPN, with the Cubs favored and returning a 1.78x payout if they win via PrizePicks.

After splitting the first two games of this series, the Cubs will try to take the rubber match with SP Colin Rea (7-6, 4.74 ERA) on the mound. The Tigers will counter with SP Keider Montero (6-5, 3.22 ERA), who had been pitching out of the bullpen recently.

Below, we’ll break down our Tigers vs. Cubs prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Tigers vs. Cubs Prediction, Winner Payout, Over/Under – Wednesday, July 22

The Cubs scored 11 runs in their decisive win over the Tigers on Tuesday. Their lineup is where they have a significant advantage. Per FanGraphs, they rank second in baseball in wRC (+111), as well as fourth in wOBA (.332). Those two stats have contributed to them scoring the fourth-most runs in the majors.

The Tigers struggle at the plate, ranking 21st in runs scored. Their wRC+ is just 98, and they're batting only .238 with runners in scoring position. Across their last seven games, they scored 2 or fewer runs five times.

Tigers vs. Cubs Winner Payout, Over/Under – Wednesday, July 22

The Cubs enter Wednesday’s game as a home favorite against the Tigers, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Tigers vs. Cubs game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

• Spread: Chicago Cubs -1.5 (2.7x payout)
• Over/Under: 7.5 runs (1.75x payout Over)
• Game Winner Payout: Tigers 1.96x | Cubs 1.78x

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Team Picks data is live as of writing and is subject to change.

Tigers vs. Cubs Prediction on Winner – 7/22/26

Here are the key game stats and trends behind our Tigers vs. Cubs prediction on the winner for Wednesday, July 22.

• With their 11-2 loss on Tuesday, the Tigers fell to 20-31 on the road for the season. The Cubs improved to 30-21 at home.
• A potent lineup has helped the Cubs produce a +69 run differential. The Tigers’ run differential is +24.
• The Cubs love hitting at home, where they have a .789 OPS. On the road, they only have a .718 OPS.
• While Montero was a starter earlier in the season, he recently moved to the bullpen. He didn't throw more than 58 pitches in any of his last five appearances, so the Tigers might be forced to go to their pen early Wednesday.
• Rea has a 4.08 xFIP and a 1.22 WHIP at home, compared to a 5.35 xFIP and a 1.61 WHIP on the road.

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Tigers vs. Cubs Picks, Player Stats for PrizePicks: 7/22/26

Here are top Tigers vs. Cubs picks to target on Wednesday, July 22. Today's MLB picks for PrizePicks include OF Riley Greene and SP Colin Rea.

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Tigers OF Riley Greene vs. Cubs: 4.5 Hitter Fantasy Score

• Greene hit a home run in two of his last three games. In Monday’s 8-6 win for the Tigers, he went 2-for-5 with a homer, 2 runs scored, and 3 RBI.
• The 25-year-old has seen a decline in his power numbers compared to last season, but his wOBA has increased from .343 to .368.
• After posting a 30.7% strikeout rate and 7.0% walk rate last year, Greene's respective numbers are 27.1% and 12.6% in 2026.
• This game being in Chicago could benefit the lefty slugger because he has a 144 wRC+ on the road but a 129 wRC+ at home.
• Rea has held right-handed hitters to a .323 wOBA; lefties have registered a .355 wOBA against him.

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Cubs SP Colin Rea vs. Tigers: 4.5 Strikeouts

• Rea posted 6 strikeouts over 6 innings vs. the Twins in his last start. He finished with 91 pitches, marking the ninth time that he's thrown at least 90 pitches in a game.
• Although the righty hurler doesn’t generally miss a ton of bats, he has a higher strikeout rate at home (19.9%) than he does on the road (14.9%).
• The Tigers have the eighth-highest strikeout rate (23.2%) in the majors.
• Cubs starting pitchers have combined for 10 strikeouts over 11 innings in the first two games of this series. What makes that more impressive is that Jameson Taillon only threw 75 pitches in his return from injury on Monday.

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The Cubs will try to take their three-game series against the Tigers with a win at home on Wednesday. Rea has the potential to rack up strikeouts against a Tigers team that struggles to make contact, but he could have difficulties with Greene along the way.

Don’t wait until the first pitch — make your Tigers vs. Cubs picks on PrizePicks now and earn real money if you’re right.

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