Texans vs. Colts Prediction, Spread, NFL Picks for Week 3 – Sunday, September 27

Texans vs. Colts is set for kickoff at 1 p.m. ET on Sunday, September 27, with the Texans being 1.5-point favorites on the spread, via PrizePicks.

Following a 33-30 overtime loss to the Chiefs in Week 2, the Colts are 0-2 out of the gate. The Texans are also 0-2, with their vaunted defense having already given up 56 points. The Jaguars (1-1) are the only team in the AFC South that has a win through two weeks. Who will join that group on Sunday?

Below, we’ll break down our Texans vs. Colts prediction and picks for NFL Week 3, including the spread, over/under, and key player picks for PrizePicks.

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Texans vs. Colts Prediction, Spread, Over/Under – Sunday, September 27

Both teams are dealing with key injuries heading into this matchup. The Colts will be without WR Alec Pierce (heel), leaving Josh Down and Keenan Allen to lead them at the position. They quickly signed WR Darius Slayton, who has experience playing with Colts QB Daniel Jones on the New York Giants.

The Texans have their own issues at wide receiver. WR Jayden Higgins (knee) is out for the season, and WR Tank Dell (knee) is also on injured reserve. WR Nico Collins (hamstring) missed Week 2 and did not practice Wednesday or Thursday, putting his status in doubt for Sunday.

When his injury was first reported, it was said that he could miss two games.

Texans vs. Colts Spread, Over/Under – Sunday, September 27

The Texans enter Sunday’s game as a 1.5-point road favorite against the Colts, via PrizePicks, returning a 1.72x payout with a win.

Here are the full payouts for the Texans vs. Colts game on PrizePicks.

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PrizePicks data is live as of writing and is subject to change.

Texans vs. Colts Prediction on Over/Under – 9/27/26

Here are the key game stats and trends behind our Texans vs. Colts prediction on the over/under for Sunday, September 27.

• Without Collins last week, the Texans were limited to 6 points by the Bengals. TE Dalton Schultz recorded 140 receiving yards, but no other Texan finished the game with more than 37 receiving yards.
• Former Lions RB David Montgomery hasn't been efficient with his new team, converting 26 rush attempts into just 70 yards.
• The Texans struggled against Bills QB Josh Allen in Week 1, but they were first in dropback EPA/play allowed last season, per RBSDM. They limited Bengals QB Joe Burrow to 207 yards through the air last week.
• When these teams played each other in Indianapolis last year, the Texans won a low-scoring affair 20-16.
• According to Team Rankings, dating back to 2024, Houston games within the division have exceeded the listed point total just five times in 12 tries.

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Texans vs. Colts Picks, Player Stats for PrizePicks: 9/27/26

Here are top Texans vs. Colts picks to target on Sunday, September 27. Week 3 NFL picks for PrizePicks include Texans TE Dalton Schultz and Texans WR Jaylin Noel.

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Texans TE Dalton Schultz vs. Colts: 50.5 Rec Yards

• Schultz hauled in 12 of 14 targets during his 140-yard performance last week. He's been targeted 22 times through two games.
• Last season, the former Dallas Cowboy set career highs in targets (106), receptions (82), and receiving yards (777).
• Per RotoWire, Schultz has a 24.1% target share and has been targeted on 30.1% of his routes in 2026.
• The Colts allowed 15 receptions for 167 yards and 1 TD to tight ends over their first two games. Last year, they allowed the seventh-most receptions and the second-most receiving yards to the position.
• In two games against the Colts in 2025, Schultz finished with 55 and 73 receiving yards.

Add Dalton Schultz + Texans to win to your PrizePicks NFL lineup now!

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Texans WR Jaylin Noel vs. Colts: 16.5 Yards on Longest Rec

• Noel caught both of his targets for a combined 53 yards in Week 1. Although he only hauled in 1 of 5 targets last week, the lone catch went for 31 yards. That gave him a reception of at least 20 yards in both games.
• The second-year receiver caught 26 passes last year, which included 6 receptions of at least 20 yards. He even had 2 receptions of 40+ yards.
• Noel logged 48 offensive snaps with Collins sidelined last week compared to his 24 snaps in Week 1 with Collins healthy.
• Texans QB C.J. Stroud said that he and Noel have deep-ball chemistry, which is important because they could be without Collins and his big-play upside again. Last season, Collins had an average depth of target of 13.3 yards, which ranked 16th among 81 WRs, per PFF.

Add Jaylin Noel + Texans to cover the spread to your PrizePicks NFL lineup now!

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Injuries could limit the scoring upside of the Week 3 matchup between the Texans and Colts. Still, Schultz has the potential for another productive stat line as one of the leading pass-catchers for the Texans. Noel doesn’t have the same type of role, but he could be the club’s best deep threat.

Don’t wait until kickoff — make your Texans vs. Colts picks on PrizePicks now and earn real money if you’re right.

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