The Boston Red Sox (6-11) and Minnesota Twins (11-7) are concluding a three-game series on Wednesday, April 15, at 1:40 p.m. ET, with the Red Sox returning a 1.69x payout on PrizePicks Team Picks if they secure a victory.
The Red Sox have already lost the first two games of the series, being outscored by a combined score of 19-6, so the Twins could secure a convincing sweep on Wednesday.
Below, we'll break down our Red Sox vs. Twins prediction and picks for Wednesday’s MLB showdown, including the run line, over/under, and key player picks for PrizePicks.
Make your picks for Red Sox vs. Twins on PrizePicks now.
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Red Sox vs. Twins Prediction, Winner Payout, Over/Under – Wednesday, April 15
To put a bow on the series, it'll be the Red Sox’s Connelly Early (4.05 xFIP across 3 starts and 13.2 IP in 2026) and the Twins’ Simeon Woods Richardson (5.19 xFIP across 3 starts and 15.2 IP) on the bump.
Early is one of Boston’s top prospects, so there are decent expectations for him. While his 61st percentile strikeout rate (24.6%) is solid, his 27th percentile xERA (5.25) and 37th percentile xBA (.258), via Baseball Savant, are a bit concerning.
Even though it’s still early in the new campaign, the Red Sox’s bats have been ice cold, posting the ninth-worst wRC+ (88), ninth-worst wOBA (.305), and 11th-highest strikeout rate (23.9%), per FanGraphs.
In addition to Richardson struggling to get the ball past batters with a fifth percentile strikeout rate (12.3%), he’s also in the 36th percentile in xERA (4.63) and 31st percentile in xBA (.266) to get the 2026 MLB season started.
Minnesota’s bats have been producing formidable metrics so far, logging the sixth-best wRC+ (112), fifth-best wOBA (.335), and fourth-best ISO (.166) in baseball.
Red Sox vs. Twins Winner Payout, Over/Under – Wednesday, April 15
The Red Sox enter Wednesday’s game as road favorites, returning a 1.69x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Red Sox vs. Twins game on PrizePicks.
- Spread: Boston Red Sox -1.5 (2.17x payout)
- Over/Under: 8.5 (2x payout on Over)
- Game Winner Payout: Red Sox 1.69x | Twins 2.04x
Play the Red Sox vs. Twins spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Red Sox vs. Twins Prediction to Win – 4/15/26
Here are the key game stats and trends behind our Red Sox vs. Twins prediction on the winner for Wednesday, April 15.
Lock in your Red Sox vs. Twins prediction on PrizePicks before the line moves.
- Besides winning eight of their last nine games, the Twins have excelled against left-handed pitchers to begin the 2026 campaign, and Early is a left-handed hurler.
- Minnesota leads the league in PAs against lefties (314), accruing the sixth-best wRC+ (114), seventh-best wOBA (.337), and seventh-highest walk rate (11.8%) in that split.
- With the fourth-most PAs against righties (511), Boston has the seventh-worst wRC+ (88), seventh-worst wOBA (.304), and fifth-worst ISO (.111).
- The Twins have gotten off to an impressive start at home, earning a 7-2 record to begin the season.
- Meanwhile, the Red Sox have gone a forgettable 3-8 away from Fenway Park this year.
- While Minnesota’s bullpen has the eighth-worst xERA (4.76) and 17th-worst HR/9 (0.86), Boston’s bullpen has been even worse with the third-worst xERA (5.10) and third-worst HR/9 (1.79).
Red Sox vs. Twins Player Picks, Stats for PrizePicks: 4/15/26
Here are the top Red Sox vs. Twins picks to target on PrizePicks for Wednesday, April 15. Today’s MLB picks for PrizePicks include CF Byron Buxton and RF Wilyer Abreu.
Twins CF Byron Buxton vs. Red Sox Projection: 5.5 Hitter Fantasy Score
- Byron Buxton crushed lefties to the tune of a 178 wRC+, .427 wOBA, and .370 ISO in 2025.
- Buxton also notched a 136 wRC+, .367 wOBA, and .276 ISO at home a season ago. To begin 2026, he has a stellar 214 wRC+, .485 wOBA, and .344 ISO across his first 37 PAs.
- Over the first two matchups against the Red Sox this series, Buxton has totaled 6 hits, 3 RBIs, and 3 HRs in 10 PAs.
- Even though it’s a limited sample, Early is permitting a .423 BABIP and 1.74 WHIP against right-handed hitters.
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Red Sox RF Wilyer Abreu vs. Twins Projection: 5 Hitter Fantasy Score
- Wilyer Abreu has been a bright spot in Boston’s lineup, registering a 163 wRC+, .414 wOBA, and .227 ISO across his first 71 PAs.
- After having a 4.91 xFIP, 1.29 WHIP, and 1.33 HR/9 against lefties last season, Richardson has respective marks of 5.36, 1.50, and 2.45 in that split to begin this season.
- Abreu is tied for the most HRs (3) on the Red Sox, and Richardson is in the 29th percentile in barrel rate (11.3%) and 29th percentile in hard-hit rate (45.3%).
- With Abreu on the visiting team, he could see at least four PAs against Richardson and Minnesota’s shaky bullpen.
Add Wilyer Abreu to your PrizePicks Lineup now.
Make Red Sox vs. Twins Picks on PrizePicks
The Red Sox are searching for answers early in the season, while the Twins are rolling in recent outings. Will Boston avoid a three-game sweep against Minnesota on Tuesday?
Don’t wait until the first pitch happens — make your Red Sox vs. Twins picks on PrizePicks now and earn real money if you’re right.
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