Red Sox vs. Rays Prediction, MLB Picks for Sunday, September 20

The Boston Red Sox and the Tampa Bay Rays will battle to wrap up a three-game series on Sunday, September 20, at 1:40 p.m. ET. Ahead of the first pitch, the Rays are a home favorite with a 1.63x payout to secure a victory on PrizePicks.

Entering Sunday’s matchup, Tampa Bay is in the driver’s seat to win the American League East, as they sit 5.0 games ahead of the New York Yankees and 10.5 games ahead of Boston. However, the Red Sox are positioned well to be a Wild Card team, owning a 5.0-game lead over the Chicago White Sox for the second AL Wild Card spot.

Below, we'll break down our Red Sox vs. Rays prediction and picks for Sunday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.

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Red Sox vs. Rays Prediction, Winner Payout, Over/Under – Sunday, September 20

For the final game of the series, Red Sox SP Patrick Sandoval (4.32 xFIP across 57.2 IP) and Rays SP Griffin Jax (3.43 xFIP across 104.1 IP) will square off on the mound.

Ahead of his 13th start of the season, Sandoval’s eighth-percentile xERA (5.30) is even worse than his actual ERA (4.99), per Baseball Savant. Sandoval is also in the sixth percentile in xBA (.280).

Despite owning a 3.80 ERA, Jax ranks in the 34th percentile in xERA (4.39) and 30th percentile in xBA (.254). After making a combined 16 starts in his first five seasons, Jax is set to make his 22nd start of the year on Sunday.

Across the last two weeks, the Red Sox have produced the fourth-worst wRC+ (79), fourth-worst wOBA (.288), and seventh-worst ISO (.139), per FanGraphs. During the same 14-game span, the Rays have tallied the 14th-best wRC+ (104), 15th-best wOBA (.322), and 15th-best ISO (.160).

On PrizePicks, Boston has the seventh-lowest payout to win the World Series (14.28x), compared to Tampa Bay boasting the fourth-lowest payout (8.33x).

Red Sox vs. Rays Winner Payout, Over/Under – Sunday, September 20

The Rays enter Sunday’s game as a home favorite against the Red Sox, returning a 1.63x payout if they win outright on PrizePicks.

Here are the full payouts for the Red Sox vs. Rays game on PrizePicks.

Make your Red Sox vs. Rays prediction on the winner on PrizePicks now!

PrizePicks data is live at the time of writing and is subject to change.

Red Sox vs. Rays Prediction on Winner – 9/20/26

Here are the key game stats and trends behind our Red Sox vs. Rays prediction on the winner for Sunday, September 20.

• Jax has been dealing recently, giving up 1 or fewer ER in six of his last seven starts.
• In his first 21 starts, Jax is in the 72nd percentile in strikeout rate (25.6%) and 68th percentile in groundball rate (45.6%).
• Sandoval has given up 3 or more ER in three straight starts.
• Plus, Sandoval is in the 19th percentile in walk rate (10.9%) and 19th percentile in groundball rate (37.1%).
• On the road this season, Sandoval has a 1.79 WHIP and an 11.6% walk rate.
• Over the last 30 days, the Rays have posted the 14th-best wRC+ (100), second-lowest strikeout rate (15.0%), and eighth-highest walk rate against left-handed pitching.
• When facing right-handed pitching in the last month, the Red Sox have the 14th-worst wRC+ (97), 15th-worst wOBA (.314), and 12th-worst ISO (.154).

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Red Sox vs. Rays Picks, Player Stats for PrizePicks: 9/20/26

Here are the top Red Sox vs. Rays picks to target on Sunday, September 20. Today’s MLB picks for PrizePicks include Junior Caminero and Griffin Jax.

Rays 3B Junior Caminero vs. Red Sox: 6.5 Hitter Fantasy Score

• Caminero is registering a 159 wRC+, .400 wOBA, and .214 ISO against left-handed pitchers in 2026.
• At home this season, Caminero has a 156 wRC+, .395 wOBA, and .282 ISO.
• Across Caminero’s last 10 games, he’s totaled 2 HRs, 4 RBIs, 3 doubles, and 6 runs scored.
• Since the start of September, Sandoval has a 4.22 xFIP, .487 BABIP, and 2.05 WHIP.

Add Junior Caminero to your PrizePicks lineup now.

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Rays SP Griffin Jax vs. Red Sox: 5 Strikeouts

• Jax has racked up 5 or more strikeouts in five of his last seven starts.
• On July 17 against the Red Sox, Jax notched 6 strikeouts in 5.0 IP.
• Along with Jax ranking in the 90th percentile in chase rate (35.2%) and 85th percentile in whiff rate (30.1%), Boston has the seventh-highest swing rate on pitches outside the strike zone (34.3%) this season.
• Across the last 14 days, the Red Sox have the seventh-highest strikeout rate against righties (24.9%).

Add Griffin Jax to your PrizePicks lineup now.

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The Red Sox and Rays are both primed to make the postseason, but it’s vital to finish the season strong and gather momentum entering the playoffs. With Jax on the bump at home on Sunday, Tampa Bay could have a slight edge.

Don’t wait until the first pitch happens — make your Red Sox vs. Rays picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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