The Boston Red Sox and Houston Astros continue their three-game set after the Astros rolled to a series-opening victory. Houston is listed as home favorites and returns a 1.63x payout with a victory against Boston at 8:10 p.m. ET.
Houston rebounded from an 0-2 start to win three consecutive games, capped off by Monday’s 8-1 rout of Boston. Boston won its opener at Cincinnati but looks to end a three-game skid heading into tonight’s contest.
Let’s look at the Red Sox vs. Astros prediction and pick for Tuesday’s tussle at Daikin Park. Make your MLB picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Red Sox vs. Astros Prediction, Winner Payout, Over/Under
Boston captured four of six matchups from Houston last season, including a three-game sweep at Fenway Park.
In Monday’s win, the Astros limited the Red Sox to 4 hits while Boston struck out 12 times. Houston went deep four times, including a pair of homers from 2B Jose Altuve, who finished 4-for-4 with 4 runs scored.
Red Sox vs. Astros Winner Payout, Over/Under
The Astros enter this matchup as home favorites, returning a 1.63x payout on PrizePicks Team Picks if they win outright.
The Red Sox are road underdogs with a 2.17x payout if they win, via PrizePicks Team Picks, where you can earn money with your predictions in 35 states!
- Spread: Houston Astros -1.5 (2.32x)
- Over/Under: 7.5
- Game Winner Payout: Red Sox 2.17x | Astros 1.63x
Team Picks data is live at the time of writing and is subject to change.
Red Sox vs. Astros Prediction on Winner – 3/31/26
Here are some key stats to know before locking in your Red Sox vs. Astros prediction for Tuesday, March 31 on PrizePicks.
- Boston’s offense has been held to 3 or fewer runs in three of four games.
- Houston rebounded from a slow start to score 28 runs in the past three victories after plating 2 runs in the first two losses.
- The Astros are second in the league in hits with 44, four behind the Tampa Bay Rays.
- The Red Sox are 4-8 in their last 12 road games against AL West foes. The Astros have won 10 of their last 17 at home facing AL East squads.
- Astros P Hunter Brown split a pair of starts against Boston last season. He defeated the Red Sox at home, 4-1, but picked up a no-decision in an extra-innings setback in Boston.
- Red Sox P Brayan Bello hasn't faced the Astros since 2023.
Red Sox vs. Astros Picks for PrizePicks Today: 3/31/26
Here are three top Red Sox vs. Astros picks to target on Tuesday. Key PrizePicks player projections are headlined by three players: Red Sox P Brayan Bello, Astros P Hunter Brown, and Houston DH Yordan Alvarez.
Red Sox P Brayan Bello vs. Astros Projection: 4 Strikeouts
- Bello’s K/9 rate was the lowest of his career last season at 6.7 after an 8.48 mark in 2024.
- In 2025, the right-hander finished with 4 or fewer strikeouts in 17 of 28 starts.
- Houston’s offense has struck out three or fewer times in three of five games against opposing SPs.
- Bello has shut down the double-play duo of Altuve and SS Carlos Correa. The two Astros star infielders are 1-for-11 with 4 strikeouts against the 26-year-old.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Astros P Hunter Brown vs. Red Sox Projection: 6.5 Strikeouts
- Brown dominated the Angels on Opening Day, posting 9 Ks in a 3-0 defeat.
- In two starts against Boston last season, the righty compiled 6 Ks at Fenway Park and 4 Ks at home.
- Boston’s lineup struck out 19 times in the last three games against opposing starters, all right-handers.
- The top strikeout victim for Brown when facing the Red Sox is LF Jarren Duran, who has struck out five times in seven career at-bats.
Astros DH Yordan Alvarez vs. Red Sox Projection: 6.5 Hitter Fantasy Score
- Alvarez started the season 0-for-3 but bounced back with 6 hits in the last 15 at-bats.
- In last night’s blowout of Boston, Alvarez hit a bomb to right field for his second home run of the season.
- Alvarez compiled a fantasy score of at least 7 in each of the past four games.
- The Cuban slugger sits in the 93rd percentile in xwOBA and xSLG and in the 98th percentile in average exit velo, via Baseball Savant.
Make Red Sox vs. Astros Picks on PrizePicks
Can Boston bounce back from last night’s loss to Houston? The Astros’ offense looks to stay hot against Bello, who makes his first start of the season. There’s never been a better time to add to the excitement of every MLB moment than with PrizePicks.
There's a wide variety of player stat projections on the MLB board. Just pick at least two player stat projections to build your Lineup on PrizePicks. Or, make your picks on winners, spreads, and over/unders on Team Picks, now available in 35 states.
Check out the Playbook throughout the season for more MLB picks, predictions, and news every day.
