The Boston Red Sox (1-4) and Houston Astros (4-2) are one of the many MLB matchups scheduled for Wednesday, with this particular clash beginning at 2:10 p.m. ET.
This is the third and final game of the series between the Red Sox and Astros, as Houston has won the first two meetings by a combined score of 17-3.
Below, we’ll break down our Red Sox vs. Astros prediction and picks for Wednesday’s matchup. Make your MLB picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Red Sox vs. Astros Prediction, Spread, Over/Under
To conclude the series, Red Sox’ Garrett Crochet (2.64 xFIP in 2025) and Astros’ Mike Burrows (3.86 xFIP) are slated to be the starters on the bump for Wednesday’s clash.
Crochet got his 2026 campaign started on the right foot, with the left-handed ace tossing a six-inning shutout with 8 strikeouts against the Cincinnati Reds on March 26 (Opening Day).
It’s been primarily Boston’s bats that have let the team down, as the Red Sox find themselves on a four-game losing streak.
While Burrows logged 5.2 IP and had 6 Ks in his season debut on March 27 against the Los Angeles Angels, he also surrendered 5 runs in a loss. Following a two-game losing streak to begin the season, the Astros have secured four straight victories.
Red Sox vs. Astros Spread, Over/Under
The Astros enter Wednesday’s game as home underdogs, returning a 2.22x payout on PrizePicks Team Picks if they win outright.
The Red Sox are road favorites with a 1.63x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Red Sox -1.5 (2.17x payout)
- Over/Under: 7.5 Runs (2.08x payout on over)
- Game Winner Payout: Astros 2.22x | Red Sox 1.63x
Team Picks data is live at the time of writing and is subject to change.
Red Sox vs. Astros Prediction to Win – 4/1/26
Here are the key stats to know before locking in your Red Sox vs. Astros prediction on the winner for Wednesday, April 1, on PrizePicks.
- Crochet was in the 91st percentile in xERA (2.89), 83rd percentile in xBA (.210), 93rd percentile in strikeout rate (31.3%), and 81st percentile in groundball rate (49.3%) in 2025, per Baseball Savant.
- While Crochet earned an 18-5 record last season across 32 starts, the Red Sox went 23-9 in the games he was on the mound.
- Boston performed well as a road favorite in 2025, recording the third-best record in the league (20-15) in that split.
- Along with the Red Sox going 64-53 when facing an American League opponent a season ago, the Astros were 56-58 in the same split.
- Despite Burrows having a potential breakout season, he was shaky in his first start of the campaign. Burrows issued 2 walks and allowed 9 hits in the Astros’ 6-2 defeat to the Angels on March 27.
- With Boston having a few dangerous left-handed sluggers, it’s worth noting that Burrows posted a 4.19 xFIP and 1.28 WHIP against lefties last year, per FanGraphs.
Red Sox vs. Astros Picks for PrizePicks Today: 4/1/26
Here are the top Red Sox vs. Astros projections to target for Wednesday, April 1, on PrizePicks. Today’s MLB picks for PrizePicks are headlined by Red Sox LF Roman Anthony and Astros SP Mike Burrows.
Red Sox LF Roman Anthony vs. Astros Projection: 6.5 Hitter Fantasy Score
- According to FanGraphs, Roman Anthony accrued a stellar 140 wRC+, .376 wOBA, and .171 ISO across 303 PAs in 2025.
- Anthony registered a 153 wRC+, .396 wOBA, and .180 ISO against right-handed hurlers last season.
- With Anthony hitting out of the leadoff spot on the visiting team, he may have an increased chance of seeing at least 5 PAs. He's hitting ahead of SS Trevor Story (102 wRC+ vs. RHP in 2025), Jarren Duran (133 wRC+), and Wilyer Abreu (115 wRC+).
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Astros SP Mike Burrows vs. Red Sox Projection: 1.5 Walks Allowed
- Burrows walked multiple batters in his first start against the Angels, who were 18th in walk rate (8.2%) when facing right-handed pitchers in 2025.
- The Red Sox were 16th in walk rate against righties last season (8.4%), and while it’s still really early, they have the 10th-highest mark (11.2%) in that split to begin this season.
- Boston could deploy at least four left-handed hitters in their lineup on Wednesday; Burrows had a 10.6% walk rate against LHH in 2025.
Make Red Sox vs. Astros Picks on PrizePicks
The Red Sox are hoping Crochet can help them snap their four-game losing streak and avoid a sweep against the Astros on Wednesday. On the other hand, Houston would love to extend its winning streak to five games.
You can make your Red Sox vs. Astros picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
