Phillies vs. Cardinals Prediction, MLB Picks for Wednesday, August 12

The Philadelphia Phillies vs. St. Louis Cardinals game is set for a first pitch at 2:15 p.m. ET on Wednesday, August 12 at Busch Stadium, with the Phillies entering as road favorites and returning a 1.56x payout to win, via PrizePicks. 

Today’s rubber match is an important contest in the NL Wild Card race after the Cardinals (60-60) climbed back to .500 with a 2-0 shutout on Wednesday.

The Phillies (64-57) remain tied for second in the Wild Card standings with the Diamondbacks and Padres despite last night’s loss, falling to 7-4 in the last 11 games.

Below, we'll break down our Phillies vs. Cardinals prediction and picks for Wednesday's MLB game, including the winner, over/under, and key player picks for PrizePicks.

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Phillies vs. Cardinals Prediction, Winner, Over/Under – Wednesday, August 12

Philadelphia held off St. Louis in Monday’s series opener, 6-5, highlighted by OF/IF Edmundo Sosa’s 3-RBI performance. The Phillies’ offense couldn’t get going against St. Louis P Andre Pallante last night, producing 5 total hits in their third shutout since the All-Star break.

The Cardinals improved to 9-15 dating back to July 18, as St. Louis sits 3.5 games behind the second-place trio in the Wild Card standings. Following today’s matinee, the Redbirds embark on a 10-game road trip, starting Friday at Wrigley Field against the rival Cubs.

St. Louis ranks fourth in MLB in xwOBA at .323, but the Cards are the only team in the top eight of xwOBA that owns a wRC+ of less than 100 (95).

Since Philadelphia was last shut out at Miami on July 28, the Phillies averaged 5.58 runs over a 12-game stretch before Tuesday’s defeat. 

Phillies vs. Cardinals Winner, Over/Under – Wednesday, August 12

The Phillies enter Thursday’s game as a road favorite against the Cardinals, returning a 1.56x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Phillies vs. Cardinals game on PrizePicks.

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Team Picks data is live at the time of writing and is subject to change.

Phillies vs. Cardinals Prediction on Winner – 8/12/26

Here are the key game stats and trends behind our Phillies vs. Cardinals prediction on the winner for Wednesday, August 12.

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• The Phillies are 5-0 in Zack Wheeler’s five daytime starts, including four shutouts.
• Wheeler sits in the 99th percentile in chase rate at 36.8%, while the Cardinals rank 14th at 30.6%.
• According to Baseball Savant, Cardinals P Kyle Leahy allows a hard-hit rate of 48.5% (second percentile) and a barrel rate of 10.7% (10th percentile).
• The Phillies have won four of the last five series finales, scoring at least 7 runs in each victory.
• Since beating the Cubs 17-1 on July 3, the Cardinals are 3-9 in their last 12 matinee affairs.

Phillies vs. Cardinals Picks, Player Stats for PrizePicks: 8/12/26

Here are top Phillies vs. Cardinals picks to target on Wednesday, August 12. Today’s MLB picks for PrizePicks include DH Kyle Schwarber and 1B Alec Burleson.

Phillies DH Kyle Schwarber vs. Cardinals: 1.5 Hits + Runs + RBI

• Schwarber leads the Phillies in hard-hit rate (52.4%) and barrel rate (17.5%), both sitting in the 96th percentile or higher.
• Against right-handed pitching, Schwarber owns an xSLG of .467 (86th percentile). Leahy is allowing an obscene xSLG of .524 to left-handed batters, ranking in the ninth percentile.
• Schwarber’s hitting streak reached six games last night, but he's eclipsed this projection only four times in this stretch.
• In the last 16 matinees, Schwarber has reached 2+ HRR four times but reached 5+ HRR in three of those instances. 

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Cardinals 1B Alec Burleson vs. Phillies: 1.5 Hits + Runs + RBI

• Burleson has picked up only 2 hits in 8 career at-bats against Wheeler, striking out once.
• In August, he produced a trio of multi-hit outings in 10 games.
• Since July 27, Burleson has finished with 1 HRR or fewer in 11 of 15 games, including last night.
• In fairness to Burleson, his hard-hit rate against right-handed pitching sits at 51.4% (95th percentile), while Wheeler resides in the 31st percentile at 42.1%.

Add Alec Burleson to your PrizePicks Lineup now.

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Philadelphia and St. Louis split the first two games of this important series at Busch Stadium. Can Wheeler bounce back from a loss in his last start and lead the Phillies to a road victory on Wednesday?

Don’t wait until lock — make your Phillies vs. Cardinals picks on PrizePicks now and earn real money if you’re right.

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