Eighth-ranked Ole Miss travels to Norman to face the 13th-ranked Oklahoma Sooners in a top-15 battle with national title and SEC title implications. The two teams are in contention for the SEC title with one loss each and in the mix for the 12-team College Football Playoff. The game from Norman, Oklahoma is set for noon ET on ABC.
Sooners’ QB QB John Mateer, who was at the top of many Heisman lists before getting hurt a month ago, leads the way for the 6-1 Sooners, while QB Trinidad Chambliss looks to continue his impressive season for the 6-1 Ole Miss Rebels.
We'll give you our Saturday Ole Miss vs. Oklahoma prediction and CFB picks for PrizePicks, including Mateer and Chambliss player picks for PrizePicks real money college football game.
Ole Miss vs. Oklahoma Prediction, Preview for Week 9
Saturday’s matchup marks the third all-time meeting between the two schools. The Rebels won the Independence Bowl following the 1999 season and also won last year at home in the first conference matchup between the two schools. Here’s a closer look at our Ole Miss vs. Oklahoma game prediction and breakdown for Saturday’s ranked vs. ranked SEC matchup.
Ole Miss Rebels Preview
- After winning their first six games of the season by an average of 18.7 points per game, the Rebels dropped a one-possession game to eighth-ranked Georgia last week.
- Ole Miss is eighth in the country in total offense (third in the SEC), averaging 491.9 yards per game and 16th in scoring offense (third in the SEC) at 37.4 points per game.
- The bulk of the offense is on the passing side, where the Rebels are eighth in the nation (second in SEC) with 304.1 passing yards per game.
- Ole Miss allowed 43 points to Georgia, but have also allowed 19+ points in four SEC games this season. Its scoring defense is ranked 52nd in the nation, allowing 22.57 points per game.
Oklahoma Sooners Preview
- The Sooners won their first five games of the season, including wins over 15th-ranked Michigan and 22nd-ranked Auburn, before dropping the Red River Rivalry to Texas two weeks ago.
- Oklahoma leads the nation in total defense, allowing just 213 yards per game and in yards per play at 3.88.
- The Sooners are also second in the nation in scoring defense, holding opponents to 9.43 points per game.
- The matchup with eighth-ranked Ole Miss is the first of five consecutive ranked opponents to end the regular season as Oklahoma travels to 17th-ranked Tennessee and then fourth-ranked Alabama before home dates with 15th-ranked Missouri and 20th-ranked LSU. ESPN FPI currently gives the Sooners 1.0 percent chance to win out.
Ole Miss vs. Oklahoma Picks for PrizePicks
Here are the player picks to target in PrizePicks real money college football game and in CFB DFS, including Trinidad Chambliss and John Mateer.
Ole Miss QB Trinidad Chambliss: 255.5 passing yards
- Ole Miss QB Trinidad Chambliss has passed for 250+ yards in each of his five starts this season, including three games of 200+ yards.
- Chambliss is a dual threat QB, gaining 40+ yards on the ground in four of his five games.
- The signal caller has a passer rating of 155.73, which is 27th in the nation and fifth in the SEC.
- Chambliss has 1+ passing TD in each of his five starts since taking over for the injured Austin Simmons. He is expected to start on Saturday.
Oklahoma QB John Mateer Projection: 258.5 passing yards
- Sooners QB John Mateer exploded onto the scene in Oklahoma’s win over Michigan, throwing for 270 yards and a TD, while running for 74 yards and 2 more TDs.
- In his first five games of the season, Mateer threw for 270+ yards in all five games, with 6 TDs and 3 INTs. In his last two games, both after his hand injury, Mateer has thrown for 176.0 yards per game with 1 passing TD and 3 INTs.
- Mateer’s 134.5 passer rating is ranked 75th among FBS QBs and 13th among 16 qualified SEC QBs.
Ole Miss RB Kewan Lacy: 72.5 rushing yards
- Ole Miss RB Kewan Lacy has 618 rushing yards this season, third-most in the SEC and 21st in the country.
- Lacy has 10 rushing TDs, second in the SEC and tied for third among all FBS running backs.
- The Ole Miss back has 65+ rushing yards in five of the seven games this season.
Make CFB Picks on PrizePicks
Ole Miss and Oklahoma, two SEC teams in the thick of the conference and playoff races, meet up in Norman, Oklahoma on Saturday.
No matter what your take on this Saturday matchup is, you can win real money with your Ole Miss vs. Oklahoma predictions on PrizePicks while you watch.
Simply pick your players — from Chambliss to Mateer — predict More or Less on their projected stats, and win cash when you're right. It's that easy.
Check out the Playbook throughout the 2025 college season for more college football picks and predictions from our team of experts.
