College football bowl season rolls on, as the week brings another pair of matchups for fans to enjoy. On Wednesday, Old Dominion and South Florida square off in the StaffDNA Cure Bowl from Camping World Stadium in Orlando, FL.
The early-evening bout (5:00 p.m. ET on ESPN) sees the Sun Belt and American Athletic Conferences clash. With both programs posting impressive 9-3 records this year, there’s no shortage of firepower, even with some high-profile players not participating.
Here, we’ll break down an Old Dominion vs. South Florida prediction and picks for the Cure Bowl. Use PrizePicks’ CFB game for player projections on bowl games and more.
Old Dominion vs. South Florida Prediction, Spread, Over/Under
Wednesday marks the first all-time meeting between Old Dominion and South Florida in either team’s history. Under head coach Ricky Rahne, the Monarchs posted their best record yet in the Sun Belt and are bowling for the first time since the 2023 campaign.
The Bulls, meanwhile, saw head coach Alex Golesh depart for Auburn. He won’t coach in the Cure Bowl, instead allowing Kevin Patrick to serve on an interim basis for the final game of the year.
Unfortunately for fans, neither team will field its normal starting QB. For Old Dominion, Colton Joseph is entering the transfer portal. USF’s Byrum Brown won’t play in the Wednesday contest, although he’ll be a de facto coach on the sideline.
Old Dominion vs. South Florida Over/Under, Spread
Old Dominion enters Wednesday’s bowl game as 2.5-point underdogs, returning a 2.08x payout on PrizePicks Team Picks if they win outright.
South Florida is the favorite to win on Wednesday with a 1.66x payout if they win, via PrizePicks Team Picks.
- Spread: South Florida Bulls -2.5
- Over/Under: 50.5
- Game Winner Payout: Monarchs 2.08x | Bulls 1.66x
Team Picks data is live at the time of writing and is subject to change.
Old Dominion vs. South Florida Prediction on Spread
Old Dominion’s offense is solid, albeit quite unspectacular. It ranks 11th in rush play percentage at 61.38 but is 126th in pass rate at 38.62%.
The Monarchs struggle plenty on fourth downs (128th) and in the red zone (119th), making it more difficult for them to sustain drives.
South Florida’s offense, meanwhile, is downright elite. It’s second in per-game scoring (41.2 points) and is fifth in yards per play (6.9).
Defensively, the Bulls are 39th in yards per play (5.1) and 54th in scoring (24.2 PPG).
This game could come down to which QB’s absence affects his team more. Old Dominion ranks in the 37th percentile in pass success rate, with South Florida being in the 87th percentile, via Game on Paper.
Make Old Dominion vs. South Florida Picks on PrizePicks
With bowl season here, Old Dominion vs. South Florida picks are far from the only ones you can dive into. With PrizePicks’ real-money CFB game, you can cash in on the action.
Doing so is simple. Just pick your players, predict More or Less for their projected stats, and earn rewards if you’re right.
Keep it here with the Playbook for continued college football predictions, picks, and news.
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