MLB Predictions Today: Dodgers vs. Braves NLDS, Guardians vs. White Sox ALDS – 10/7/26

The MLB postseason continues on Wednesday with four total games split between the NLDS and ALDS, giving fans an exciting slate of baseball. The action gets underway at 4 p.m. ET with the Chicago White Sox hosting the Cleveland Guardians in Game 3 of the ALDS.

In the nightcap, the NL takes center stage, as the Los Angeles Dodgers and Atlanta Braves will face off in Game 4 of the NLDS. In addition, the New York Yankees look to keep their season alive in Game 3 of the ALDS, while the San Diego Padres aim to even their NLDS series against the Milwaukee Brewers. 

Below, we'll break down our best MLB predictions today for two of Wednesday’s playoff games in the ALDS and NLDS. We'll highlight MLB postseason picks for the winner and over/under on PrizePicks, as well as player projections to consider.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

Make your NLDS and ALDS picks on PrizePicks today.

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Dodgers vs. Braves Prediction, Winner Payout, Over/Under for NLDS Game 4 – Wednesday, October 7

The Braves outlasted the Philadelphia Phillies in the Wild Card set and are currently embroiled in a daunting NLDS series against the Dodgers. After the Braves recorded a 3-2 win in Game 2, the Dodgers bounced back with a 3-1 victory in Game 3 to take the series lead.

In Game 4, the Dodgers will send SP Tyler Glasnow to the mound for his first start of the postseason. Meanwhile, veteran SP Tyler Mahle is on the bump for the Braves.

Mahle delivered a masterful performance against the Phillies in Game 2 of the Wild Card, surrendering just 1 earned run on 6 hits while striking out 6 batters in 7.0 innings. Atlanta lost the contest 4-3 in 10 innings, however.

The Braves have won six of the last eight matchups against the Dodgers, including four of the last five meetings at Truist Park. 

Braves vs. Dodgers Winner Payout, Over/Under for NLDS – Wednesday, October 7

The Dodgers enter Wednesday's game as road favorites against the Braves, returning a 1.63x payout with a win, via PrizePicks.

Here are the full payouts for the Dodgers vs. Braves NLDS Game 4 on PrizePicks.

Make your Dodgers vs. Braves prediction on the spread or over/under on PrizePicks.

Braves vs. Dodgers Prediction on Over/Under for NLDS Game 4 – 10/7/26

Here are the key stats and trends behind our Braves vs. Dodgers prediction on the over/under for NLDS Game 4 on Wednesday, October 7.

• The under is 7-2 in nine meetings between the Braves and Dodgers this season (including the NLDS).
• Glasnow has thrived against this current Braves lineup, registering a 33.3% strikeout rate and holding opposing hitters to a .182 batting average in 108 career plate appearances.
• Since the 2026 postseason began, the Dodgers own the third-highest wRC+ (93), while the Braves are sixth with just a wRC+ of 78.
• Glasnow has tallied a 2.88 xERA this season, which ranks in the 92nd percentile.

Lock in your Dodgers vs. Braves NLDS picks now on PrizePicks.

Dodgers vs. Braves Picks, Player Stats for NLDS on PrizePicks: 10/7/26

Here are the top Dodgers vs. Braves picks to target on Wednesday, October 7. Today’s MLB pick for PrizePicks is Tyler Glasnow.

Dodgers SP Tyler Glasnow vs. Braves: 6.5 Strikeouts

• Glasnow has registered a 34.0% strikeout rate this season, ranking in the 97th percentile. He's tallied 7+ strikeouts in nine of his 13 outings.
• The Dodgers’ right-hander owns a very impressive 32.1% whiff rate in 2026 (92nd percentile).
• In his lone start vs. the Braves this campaign, Glasnow racked up 7 strikeouts in just 5.0 innings on August 25.
• Atlanta has averaged 10.3 strikeouts per contest in three NLDS games.

Add Tyler Glasnow + Dodgers to win to your PrizePicks lineup now.

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Guardians vs. White Sox Prediction, Winner Payout, Over/Under for ALDS Game 3 – Wednesday, October 7

AL Central foes will battle it out once again as the White Sox host the Guardians in Game 3 of the ALDS. After sweeping the Houston Astros in the Wild Card, Chicago has taken the first two contests against the Guardians, including a 4-3 comeback win in Game 2.

Game 3 will be a matchup of openers as the series shifts to the Windy City. The Guardians send SP Daniel Espino to the mound, while SP Sean Newcomb gets the nod for the White Sox. 

Espino logged 0.2 innings in a 3-0 loss in Game 1, allowing only 1 hit. Meanwhile, Newcomb has recorded a 6.00 ERA in two appearances this postseason but did toss 2.0 scoreless innings in Game 2 in relief. 

Guardians vs. White Sox Winner Payout, Over/Under for ALDS Game 3 – Wednesday, October 7

The White Sox enter Wednesday's game as home favorites against the Guardians, returning a 1.81x payout with a win, via PrizePicks.

Here are the full payouts for the Guardians vs. White Sox ALDS Game 3 on PrizePicks.

Make your Guardians vs. White Sox prediction on the spread or over/under on PrizePicks.

Guardians vs. White Sox Prediction on Winner for ALDS Game 3 – 10/7/26

Here are the key stats and trends behind our Guardians vs. White Sox prediction on the winner for ALDS Game 3 on Wednesday, October 7

• The White Sox are 4-2 against the Guardians at home in 2026.
• Chicago’s lineup has been one of the more dangerous in the majors, ranking fifth with a wRC+ of 104. Meanwhile, Cleveland ranks 21st in wRC+ (97) while also scoring the third-fewest runs (3) among playoff teams.
• The White Sox could get off to a strong start with Newcomb on the mound. After all, he's held the current Guardians lineup to a .190 BA and a .275 wOBA in his career. 
• The White Sox have won seven of the last 10 matchups against the Guardians, including outscoring their division rivals 7-3 in the ALDS thus far.

Lock in your Guardians vs. White Sox ALDS picks now on PrizePicks.

Guardians vs. White Sox Picks, Player Stats for ALDS on PrizePicks: 10/7/26

Here are the top Guardians vs. White Sox picks to target on Wednesday, October 7. Today’s MLB pick for PrizePicks is Miguel Vargas.

White Sox 3B Miguel Vargas vs. Guardians: 1.5 Hits + Runs + RBI

• Vargas is hitting .500 (2-for-4) with 2 runs while also walking on four occasions in this series.
• The White Sox 3B has registered a 13.0% barrel rate on the year, which ranks in the 88th percentile.
• Vargas has tallied a hit and scored a run in both Games 1 and 2 of the ALDS.
• The Chicago slugger drew a team-high 101 walks during the regular season, including 11 against the Guardians. 

Add Miguel Vargas + White Sox to win to your PrizePicks lineup now.

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The Division Series round of the MLB postseason will continue on Wednesday. Can the Dodgers and Braves keep turning in low-scoring affairs? On the other hand, might the White Sox close out the ALDS against the Guardians at their home field? 

Don’t wait until first pitch — make your NLDS and ALDS picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on MLB game winners, spreads, and over/unders, now available in 36 states.

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