An intense East Coast vs. West Coast showdown between two potential National League playoff kicks off this weekend in the Mets vs. Giants. The Giants, led by newly acquired Rafael Devers, play host to the New York Mets and Juan Soto.
On Friday, we'll see the Mets vs Giants at 10:15 p.m. ET to close out a loaded night of MLB games. Below, we'll give you Mets vs Giants predictions and picks for Friday's game, including PrizePicks MLB picks.
The Giants begin a three‑game home stand against the Mets on Friday, owning a 28-20 record at Oracle Park. New York, meanwhile, carries a 22-28 record in road games. This series opener represents the first meeting between the clubs in 2025.
With the All-Star break behind us, every MLB game means more. There is no better time than now to make your MLB predictions on PrizePicks and cash in, including on Mets vs Giants tonight.
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PrizePicks MLB Picks Mets vs Giants: Friday, July 25
Here are the top MLB picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Friday, July 25. Click to read more about each pick.
- Mets P Clay Holmes – 4 Pitcher Strikeouts
- Giants 3B Rafael Devers – 1.5 Hits+Runs+RBIs
- Giants P Logan Webb – 33.5 Pitcher Fantasy Score
Mets P Clay Holmes – 4 Pitcher Strikeouts

- Over his last 110 plate appearances, Mets SP Clay Holmes has surrendered a 4.9% barrel rate, a 40% hard‑hit rate, and kept fly balls down to 13%.
- Holmes has been tagged for at least two earned runs in each of his last four starts.
- His strikeout rate has dipped sharply this stretch, falling below 12% over those 110 PAs, and he’s cleared three strikeouts in only one of his last five outings.
- The Giants own a strikeout percentage of less than 22% against RHP this season.
Giants 3B Rafael Devers – 1.5 Hits+Runs+RBIs

- In July, 3B Rafael Devers slashed .277 (18-for-65) with two home runs and five doubles, in the midst of a hot streak after a rocky start since being traded from the Red Sox.
- Against right‑handed pitching this year, in 304 plate appearances, he’s posted a 67% hard‑hit rate, a 16% barrel rate, and a .320+ BABIP
- Against Clay Holmes specifically, Devers is 2-for-7 in his career, including one of those hits going for a home run.
Giants P Logan Webb – 34.5 Pitcher Fantasy Score

- In his last 134 plate appearances, Logan Webb’s metrics have climbed above his season averages, as he's allowed a 15% barrel rate, a 51% hard‑hit rate, and a 20% fly‑ball rate — a regression closer to where he was statistically prior to this season.
- Webb has allowed two or more earned runs in five consecutive outings.
- Over the Mets’ 412 plate appearances against right‑handed pitching, New York has produced a .303 BABIP, a 10%+ barrel rate, a 50%+ hard‑hit rate, and a 30%+ fly‑ball rate.
Make MLB Predictions on PrizePicks
With the Mets vs Giants weekend series, we get matchup between two likely MLB playoff teams, with every game carrying importance.
Whether you're targeting hitters like Rafael Devers or a Logan Webb's fantasy score projection, there are hundreds of projections to make your predictions on PrizePicks.
Just build your Lineup on PrizePicks with your MLB predictions and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.