Illinois vs. #4 UCLA Prediction, Spread, NCAAF Picks – Friday, November 13

One of the two remaining undefeated teams in college football will be in action on Friday evening. The UCLA Bruins host the Illinois Fighting Illini on Friday, November 13, with the game kicking off at 9 p.m. ET on FOX. The Bruins are a 10.5-point favorite on the spread, via PrizePicks.

UCLA topped Minnesota 34-20 last week to remain atop the Big Ten standings and get to 9-0 on the year. Meanwhile, Illinois has compiled a 6-3 record and is riding a four-game winning streak entering Friday’s contest. 

Below, we’ll break down our Illinois vs. UCLA prediction and picks for Friday night’s game, including the spread, over/under, and key player projections for PrizePicks.

Make your Illinois vs. UCLA picks on PrizePicks now!

{{cfb_offer_banner="/style-system/ui-components-playbook"}}

Illinois vs. #4 UCLA Prediction, Spread, Over/Under – Friday, November 13

UCLA enters Friday's game as a 10.5-point favorite against Illinois, returning a 1.21x payout if it wins outright, via PrizePicks — or $121 on a $100 entry if you’re right.

Here are the full payouts for Illinois vs. UCLA. PrizePicks data is live at the time of writing and is subject to change.

Make your Illinois vs. UCLA prediction on the spread on PrizePicks.

Along with #2 Utah, UCLA is one of just two undefeated teams remaining in the FBS. The Bruins have won all six of their Big Ten contests, including beating Oregon, Wisconsin, and Minnesota.

In UCLA’s 17-15 win against Oregon on October 10, the Bruins lost starting QB Nico Iamaleava for the rest of the campaign with a torn ACL. Without Iamaleava, UCLA has turned to QB Ty Dieffenbach, who's actually been fairly successful.

Dieffenbach has completed 57.8% of his passes for 986 yards and 6 TDs with 2 INTs in five games since taking over. In his most recent contest, the senior QB completed 8 of 16 passes for 303 yards, 3 TDs, and 1 INT against Minnesota.

UCLA’s QB production isn’t as explosive with Dieffenbach stepping in, though. As a result, the Bruins lean on their rushing attack and star RB Wayne Knight. Knight, who leads the team with 689 rushing yards, followed head coach Bob Chesney from James Madison and has been a workhorse. 

The Bruins have also relied on a stout defense that ranks among the country's shutdown units. UCLA's allowed just 14.1 PPG, which ranks eighth nationally.

Meanwhile, Illinois has enjoyed a very successful campaign despite getting off to a slow start in Big Ten play. Illinois dropped its opening two games of conference action to Ohio State and Purdue, only to rebound with four consecutive wins.

While the Fighting Illini may not have an elite offense, QB Katin Houser does have one of the conference's most dependable targets in WR Collin Dixon. Dixon ranks second in the Big Ten in receptions (68), receiving yards (910), and receiving TDs (12). 

Defensively, Illinois is vulnerable, ceding the fourth-most yards per game in the Big Ten (376.8) and a conference-worst 245.6 passing YPG.

Illinois vs. UCLA Prediction on Spread – 11/13/26

Here are the key stats and trends behind our Illinois vs. UCLA pick against the spread for Friday, November 13.

• UCLA has a perfect 9-0 against-the-spread record this season.
• The Bruins have allowed a minuscule 9.3 PPG in their last four games.
• The Bruins are among the most dominant defenses in the FBS, allowing the seventh-fewest YPG (264.7).
• UCLA’s defense has also given up just -0.15 EPA/rush (fifth), per Game on Paper.
• In contrast, Illinois has averaged 236.9 passing YPG, sitting ninth in the Big Ten.
• Offensively, UCLA is second in the Big Ten with 431.9 YPG. Additionally, the Bruins have racked up the second-most rushing YPG in the conference (213.2) and have recorded 0.08 EPA/rush (48th nationally).

Lock in your Illinois vs. UCLA prediction on PrizePicks before kickoff.

Illinois vs. UCLA Picks, Player Stats for PrizePicks: 11/13/26

Here are the top Illinois vs. UCLA picks to target on Friday, November 13. Today’s college football picks for PrizePicks include QB Katin Houser and RB Wayne Knight.

Illinois QB Katin Houser vs. UCLA: 212.5 Pass Yards

• Houser has completed 64.3% of his passes for 1,955 yards and 16 TDs with 5 INTs in eight games.
• The Illinois QB has averaged 6.91 yards per dropback, ranking 48th among QBs in the nation.
• UCLA's defense has recorded -0.29 EPA/pass (first nationally) and also allowed the 18th-fewest passing yards per game in the FBS (177.0).
• The Bruins have only allowed opposing QBs to throw for 213+ yards in two games.

Pick Katin Houser + Illinois to win on PrizePicks!

{{cfb_offer_banner="/style-system/ui-components-playbook"}}

UCLA RB Wayne Knight vs. Illinois: 84.5 Rush Yards

• Knight leads the Big Ten in rushing yards (689) and rushing TDs (13) and ranks third in yards per carry (6.2).
• The Bruins RB has recorded 0.24 EPA/rush, good for a more than respectable ranking of 41st among collegiate RBs.
• Knight's recorded 85+ rushing yards in five games, including notching 18 carries for 109 yards and a TD against Minnesota last week.
• The Illinois defense has surrendered 0.12 EPA/rush on the year, 108th in the country.

Add Wayne Knight + UCLA to cover the spread to your PrizePicks lineup now.

Make Illinois vs. UCLA Picks on PrizePicks

UCLA is one of only two undefeated teams in the collegiate ranks. Can the Bruins keep riding the backs of their stingy defense to a convincing win against the Fighting Illini on Friday night?

Don’t wait until kickoff — make your Illinois vs. UCLA picks on PrizePicks now.

Pick college football players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

Stay locked in on Playbook for college football predictions, picks, and news all the way through the 2026 College Football Playoff.