Giants vs. Dodgers Prediction, MLB Picks for Wednesday, May 13

6 min read

Published:

May 13, 2026 5:00 PM

Los Angeles Dodgers SP Shohei Ohtani throws during a game against the Minnesota Twins.

AP Photo/Jayne Kamin-Oncea

The San Francisco Giants (18-24) and Los Angeles Dodgers (24-18) are set to square off for the third game of a four-game series on Wednesday, May 13, at 10:10 p.m. ET. San Francisco has won the first two meetings by a combined score of 15-5, so the reigning World Series champions are looking to get back on track.

Ahead of the first pitch on Wednesday, the Dodgers are massive home favorites with a 1.36x payout if they defeat the Giants, via PrizePicks Team Picks.

Below, we'll break down our Giants vs. Dodgers prediction and picks for Wednesday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.

Make your Giants vs. Dodgers prediction on PrizePicks for today’s game.

Giants vs. Dodgers Prediction, Spread, Over/Under – Wednesday, May 13

For the third game of the series between these National League West rivals, it will be the Giants’ Robbie Ray (4.15 xFIP across 8 starts and 45.2 IP in 2026) and the Dodgers’ Shohei Ohtani (3.11 xFIP across 6 starts and 37 IP) getting the nod on the mound.

Ray can be a bit volatile given his career 10.0% walk rate and 44th percentile xERA (4.17), via Baseball Savant, and his 2.76 ERA suggests he could be due for negative regression soon. The experienced southpaw has given up at least 1 HR in six of his eight outings so far.

Despite the Giants’ success at the plate in this series, they’re still swinging a cold bat to begin the 2026 MLB season, earning the third-worst wRC+ (87), second-worst wOBA (.293), and fifth-worst ISO (.125), per FanGraphs.

While Ohtani has yet to hit his stride as a hitter this season, the hard-throwing righty is in the 95th percentile in xERA (2.17), 93rd percentile in xBA (.182), and 83rd percentile in walk rate (6.2%) when pitching. On Tuesday, Ohtani ended an 11-game drought of not hitting a homer, though the Dodgers have been omitting him from the lineup when he starts on the bump.

Even with some of Los Angeles’ hitters struggling, it still boasts the second-best wRC+ (119), second-best wOBA (.343), and third-best ISO (.168) in the league.

According to PrizePicks Team Picks, a prediction of “Yes” on the Dodgers to win the World Series again still carries a 3.33x payout.

Giants vs. Dodgers Spread, Over/Under – Wednesday, May 13

The Dodgers enter Wednesday’s game as home favorites against the Giants, returning a 1.36x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Giants vs. Dodgers game on PrizePicks.

Spread: Los Angeles Dodgers -1.5 (1.85x payout)
Over/Under: 7.5 (1.78x payout on Over)
Game Winner Payout: Giants 2.85x | Dodgers 1.36x

Make your Giants vs. Dodgers prediction on spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Giants vs. Dodgers Prediction on Winner – 5/13/26

Here are the key game stats and trends behind our Giants vs. Dodgers prediction on the winner for Wednesday, May 13.

Lock in your Giants vs. Dodgers prediction on PrizePicks before the line moves.

Along with his elite metrics mentioned above, Ohtani also resides in the 90th percentile in barrel rate (3.3%) and 87th percentile in groundball rate (53.8%).
Against right-handed pitchers, the Giants have the fourth-worst wRC+ (89), third-worst wOBA (.296), and eighth-worst ISO (.133).
While San Francisco has better production away from pitcher-friendly Oracle Park, it still has the 10th-worst wRC+ (89), 10th-worst wOBA (.299), and fifth-worst ISO (.123) on the road in 2026.
As for the Dodgers, they possess the fifth-best wRC+ (115), sixth-best wOBA (.337), and seventh-best ISO (.161) when facing lefties.
With Ray sitting in the 36th percentile in walk rate, it’s worth noting that Los Angeles also has the 11th-highest walk rate against lefties (10.1%).
Just last season, Ohtani logged a stellar 2.17 xFIP, 0.71 WHIP, and 38.5% strikeout rate at home, compared to a 2.67 xFIP, 1.31 WHIP, and 29.1% K-rate on the road.
Ohtani has a 3.18 xFIP, 0.89 WHIP, and 34.7% strikeout rate across his first three home starts this year.

Giants vs. Dodgers Picks, Player Stats for PrizePicks: 5/13/26

Here are the top Giants vs. Dodgers picks to target on PrizePicks for Wednesday, May 13. Today’s MLB picks for PrizePicks include SP Shohei Ohtani and CF Andy Pages.

Dodgers SP Shohei Ohtani vs. Giants Projection: 6.5 Strikeouts

Shohei Ohtani, 101mph Fastball and 89mph Sweeper, Individual Pitches + Overlay pic.twitter.com/tEqxf9RMLD
— Rob Friedman (@PitchingNinja) May 6, 2026

Ohtani is ranked in the 86th percentile in strikeout rate (29.0%), 90th percentile in whiff rate (32.0%), and 56th percentile in chase rate (30.9%) this season.
The two-way phenom has racked up at least 7 Ks in each of his last four starts.
Although the Giants have the 11th-lowest strikeout rate against right-handers (21.1%), they have the fifth-highest swing rate on pitches outside the strike zone (35.4%).
While San Francisco has players like 2B Luis Arraez (2.7%) and RF Jung Hoo Lee (11.6%) with low strikeout rates against righties, the Giants could deploy five+ hitters with a 23.5% strikeout rate or higher in that split on Wednesday.

Add Shohei Ohtani to your PrizePicks Lineup now.

Dodgers CF Andy Pages vs. Giants Projection: 1.5 Hits + Runs + RBI

Andy Pages joins his @Dodgers teammate Max Muncy as the only players to hit 3 homers in a game this season! pic.twitter.com/xMACpHTZnz
— MLB (@MLB) May 6, 2026

Pages has been one of the better hitters for the Dodgers to begin the year, notching a 154 wRC+, .395 wOBA, and .227 ISO across his first 168 PAs.
When facing lefties, Pages owns a 148 wRC+, .386 wOBA, and .226 ISO. He had a 117 wRC+, .337 wOBA, and .116 ISO in that split last season.
Besides getting an opportunity to hit in the middle of the Dodgers’ lineup, Pages has totaled a trio of multi-hit performances with 6 runs, 4 HRs, and 10 RBI over his last 10 contests.
After posting a 4.12 xFIP and 1.26 WHIP against right-handed hitters in 2025, Ray currently has a 4.58 xFIP and 1.21 WHIP against them to begin 2026.

Add Andy Pages to your PrizePicks Lineup now.

Make Giants vs. Dodgers Picks on PrizePicks

The Dodgers turn to Ohtani on the mound in hopes he can help snap the team’s four-game losing streak on Wednesday. Will the Giants inch closer to sweeping the reigning champs after winning the first two games of the series?

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