Giants vs. Cubs Prediction, MLB Picks for Sunday Night Baseball – 6/7/26

The first pitch of the San Francisco Giants (26-39) vs. the Chicago Cubs (34-31) is set for 8:30 p.m. ET on Sunday, June 7, with the Cubs returning a 1.75x payout to win, via PrizePicks.

After being destroyed in the first game of the series 18-3, the Cubs had an exciting comeback win on Saturday, tying the matchup in the ninth inning and walking it off in the tenth. Now, these teams will face off in a rubber match on Sunday Night Baseball on NBC and Peacock.

Below, we'll break down our Giants vs. Cubs prediction and picks for Sunday Night Baseball, including the run line, over/under, and key player picks for PrizePicks.

Make your Giants vs. Cubs picks on PrizePicks now for Sunday Night Baseball!

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Giants vs. Cubs Prediction, Winner Payout, Over/Under – Sunday, June 7

The Giants will give the ball to SP Trevor McDonald (3.24 xFIP across 6 starts and 34 IP in 2026). The 4.50 ERA does not look good on paper, but that mostly stems from one bad start, when he allowed 7 earned runs to the White Sox on May 22. He’s been dependable in his other 5 outings, allowing 3 earned runs or fewer in each start.

The loss on Saturday snapped San Francisco’s season-high three-game winning streak. It's won three consecutive games in two other instances, and each time it went on to lose at least three games after the promising stretch. 

It has been a tough year for San Francisco, and the decision to bring in former University of Tennessee coach Tony Vitello is not working out, as their .400 winning percentage is the second-worst in baseball.

The Cubs will counter with SP Jameson Taillon (4.61 xFIP across 12 starts and 66.2 IP in 2026). Taillon came into 2026 with a combined 3.45 ERA over the last two seasons, but there has been huge regression this year. There are several categories that are career-worst marks, including a 5.24 xERA, a 14.5% barrel rate allowed, and a .520 xSLG allowed.

Going into May 8, the Cubs' 27-12 record was the best in the National League, and they had a 3.5-game lead in the NL Central. Since then, their 6-19 record is the worst in MLB, and they are 6.5 games behind first in the Central. The pitching and hitting have both struggled during this split; since May 9, they rank 29th in wOBA (.289) and xERA (5.29).

Giants vs. Cubs Winner Payout, Over/Under – Sunday, June 7

The Cubs enter Sunday’s game as home favorites, returning a 1.75x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Giants vs. Cubs game on PrizePicks.

• Spread: Cubs -1.5 (2.56x payout)
• Over/Under: 7.5 (1.75x payout on Over)
• Game Winner Payout: Giants 2x | Cubs 1.75x

Make your Giants vs. Cubs prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Giants vs. Cubs Prediction on Spread for Sunday Night Baseball – 6/7/26

Here are the key game stats and trends behind our Giants vs. Cubs prediction on the run line for Sunday, June 7.

Lock in your Giants vs. Cubs prediction PrizePicks before the first pitch.

Data used in this article is from Baseball Savant or FanGraphs.

• Taillon is allowing a career-worst .353 wOBA, which is higher than the MLB average of .315. The Giants’ .340 wOBA since May 1 ranks third in the league.
• Opposing batters do well at getting the barrel on the ball, with Taillon allowing a 14.5% barrel rate, which ranks in the second percentile. The Giants sit sixth in barrel rate (9.5%) since May 23.
• On the other end, McDonald is allowing only a 4.1% barrel rate that ranks in the 89th percentile. The Cubs have struggled with a 6.8% barrel rate since May 9, which ranks 22nd in baseball.
• Chicago has been one of the worst offenses over the last month. Since May 9, they rank last in xBA (.228) and ISO (.119), while sitting 23rd in xSLG (.323).
• The Cubs have lost four of Taillon’s last five starts.

Giants vs. Cubs Picks, Player Stats for PrizePicks – 6/7/26

Here are the top Giants vs. Cubs picks to target on PrizePicks for Sunday, June 7. Today’s MLB picks for PrizePicks include Pete Crow-Armstrong and Jung Hoo Lee

Giants OF Jung Hoo Lee vs. Cubs: 5 Hitter Fantasy Score

• Lee is having one of his best seasons, as his .308 xBA, .354 wOBA, and 10.8-degree launch angle are the best of his career.
• The Giants right fielder has been one of the top hitters in baseball, leading the league with a .326 xBA while he's 11th with an 87.6% contact rate since May 1.
• Lee rarely swings and misses, as his 13.9% whiff rate ranks in the 95th percentile. Taillon is allowing a 26.4% whiff rate (60th percentile).
• Taillon has been worse against left-handed batters with a .393 wOBA and an 11.4% walk rate compared to a .313 wOBA and a 3.6% walk rate to righties.

Add Jung Hoo Lee to your PrizePicks Lineup now.

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Cubs OF Pete Crow-Armstrong vs. Giants: 6.5 Hitter Fantasy Score

• The Giants have not been able to stop Crow-Armstrong in this series, as he’s gone 5-for-7, with 2 home runs and 2 RBIs.
• The Cubs center fielder is one of the hottest hitters in baseball recently. Since May 26, he leads the league with a 1.0 WAR and is fourth with a .743 xSLG.
• Crow-Armstrong can smash the ball, as his 50.0% hard hit rate ranks in the 89th percentile. McDonald is allowing a 41.4% hard-hit rate, which ranks in the 33rd percentile.
• McDonald is a heavy sinker-ball pitcher, throwing it on 59% of his pitches. Crow-Armstrong has a great handle on the pitch with a .512 wOBA and 240 wRC+ this season.

Add Pete Crow-Armstrong to your PrizePicks Lineup now.

Make Giants vs. Cubs Picks on PrizePicks

The Giants and Cubs are searching for wins as both have struggled recently. San Francisco has a much tougher hill to climb to be competitive, but Chicago is still in the thick of the National League playoff race, as it is tied for the final wild card spot.

Who will grab the much-needed win on Sunday Night Baseball?

Don’t wait until the first pitch — make your Giants vs. Cubs picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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