Giants vs. Brewers Prediction, MLB Picks for Monday, June 1

The San Francisco Giants (23-36) and the Milwaukee Brewers (35-21) open a four-game series on Monday, June 1, at 7:40 p.m. ET on FS1. The Brewers are home favorites for the series opener, returning a 1.58x payout if they win, per PrizePicks Team Picks. 

San Francisco is 1-5 in its last six games, compared to Milwaukee’s 5-1 mark in its previous six matchups. The Brewers are one of the National League’s best, while the Giants are flirting with last place in the NL West. Will Milwaukee dominate this series?

Below, we'll break down our Giants vs. Brewers prediction and picks for Monday’s MLB game, including the winner payouts, over/under, and key player picks for PrizePicks.

Make your Giants vs. Brewers picks on PrizePicks for tonight's game.

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Giants vs. Brewers Prediction, Winner, Over/Under – Monday, June 1

As expected, the Brewers carry an advantage in team stats. According to FanGraphs, they are one of the best pitching units in the league with a 3.17 ERA (third) and 3.37 xERA (second). Meanwhile, the Giants carry a 4.35 ERA (20th) and a 4.09 xERA (14th).

At the plate, Milwaukee totals 4.8 runs per game (sixth), though its .242 batting average (tied for 14th), .359 SLG (tied for 30th), and .310 wOBA (tied for 21st) suggest negative regression may be ahead.

San Francisco logs 3.9 runs per contest (26th) but could be bound for positive regression thanks to a .254 batting average (fourth) and a .404 SLG (seventh).

The Brewers are leaning on their relievers today, as RP Shane Drohan will get the start. He’s made 10 of 11 appearances from the bullpen this season, pitching for 2.2 innings in his only start of the season on April 8. The left-handed hurler carries a 2.63 ERA and 3.41 xFIP.

For the Giants, SP Landen Roupp will make his 12th start of the season on Monday. He’s off to a terrific start, sporting a 3.30 ERA, 3.03 xERA, and 3.00 xFIP.

Giants vs. Brewers Winner Payout, Over/Under – Monday, June 1

The Brewers enter Monday’s matchup as a home favorite against the Giants, returning a 1.58x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Giants vs. Brewers game on PrizePicks.

• Spread: Milwaukee Brewers -1.5 (2.32x payout)
• Over/Under: 7.5 (1.96x payout on Over)
• Game Winner Payout: Giants 2.22x | Brewers 1.58x

Make your Giants vs. Brewers prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Giants vs. Brewers Prediction on Over/Under – 6/1/26

Here are the key game stats and trends behind our Giants vs. Brewers prediction on the run line for Monday, June 1.

Lock in your Giants vs. Brewers prediction on PrizePicks before the first pitch.

• The Giants come off an absurd 19-run, 25-hit performance against the Rockies on Sunday, but Colorado has a 5.05 xERA (29th) compared to Milwaukee’s 3.37 (second).
• Brewers RP Shane Drohan features an exceptional 2.64 xERA, and San Francisco has a .301 wOBA against left-handed pitchers (20th).
• Furthermore, Milwaukee’s bullpen touts a 3.42 xERA (fifth) while giving up a .226 batting average (tied for eighth).
• Giants SP Landen Roupp stumbled with a 5.93 ERA over his first three starts in May, but he carries an impressive 2.45 ERA in his last two appearances.
• Baseball Savant gives Roupp a 3.02 xERA (81st percentile) and .229 xBA allowed (69th percentile). 
• Plus, he limits hard contact by allowing 2.6% barrel (94th percentile) and 26.3% hard-hit rates (98th percentile), fueling 0.45 HR/9.
• The under is 7-3 over Milwaukee’s last 10 games.

Giants vs. Brewers Player Picks, Stats for PrizePicks – 6/1/26

Here are the top Giants vs. Brewers picks to target on PrizePicks for Monday, June 1. Today’s MLB picks for PrizePicks include Landen Roupp and Brice Turang.

Giants SP Landen Roupp vs. Brewers: 5.5 Strikeouts

• Roupp sports a 27.4% strikeout rate (82nd percentile), aided by a 30.0% chase rate (45th percentile) and a 26.2% whiff percentage (58th percentile).
• The Brewers carry a 21.1% K% (ninth-lowest), but they’ve posted 9.4 strikeouts per game over the last five contests — elevated from 8.1 on the season (12th-fewest).
• San Francisco’s starter averages 6.2 Ks per outing and has reached at least 6 strikeouts in nine of 11 appearances this season.
• In May, Roupp reached 6 strikeouts in four of five starts.

Add Landen Roupp to your PrizePicks Lineup now.

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Brewers 2B Brice Turang vs. Giants: 6.5 Hitter Fantasy Score

• Landen Roupp’s most-used pitches are a sinker (36.8%) and curveball (28.9%), and Brice Turang bats .263 and .421 against the pitches. 
• However, Turang is hitless over his last 19 at-bats and finished May with a .231 batting average.
• Over 7 career at-bats against Roupp, Turang has only 1 hit with a .167 batting average.
• The Brewers’ second baseman has good power with a .456 xSLG (73rd percentile), 91.1 average exit velocity (82nd percentile), and a 46.7% hard-hit rate (76th percentile). However, Roupp holds opponents to a 26.3% hard-hit rate (98th percentile).
• Turang also carries a concerning 24.2% K rate (31st percentile) that could pose trouble against a quality starter.
• He’s averaged a 2.8 hitter fantasy score per game over his last five games, failing to eclipse a 6.5 score once during the split.

Add Brice Turang to your PrizePicks Lineup now.

Make Giants vs. Brewers Picks on PrizePicks

While the Brewers outmatch the Giants in pitching, San Francisco is starting one of its best in Landen Roupp on Monday. Will a quality starter keep the Giants close as the underdog?

Don’t wait until the first pitch — make your Giants vs. Brewers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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