Dodgers vs. Padres Prediction, MLB Picks for Saturday, June 27

The Los Angeles Dodgers vs. San Diego Padres game is set to begin at 8:40 p.m. ET on Saturday, June 27, with the Dodgers returning a 1.47x payout if they land in the win column, per PrizePicks.

The Padres got the three-game series started on the right foot with a convincing 7-1 win on Friday. San Diego 1B Todd France led the way with a 3-run home run in the third inning to give his team a lead that they would never relinquish.

Below, we'll break down our Dodgers vs. Padres prediction and picks for Saturday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.

Make your picks for Dodgers vs. Padres on PrizePicks now.

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Dodgers vs. Padres Prediction, Winner Payout, Over/Under – Saturday, June 27

In Saturday’s contest, Dodgers SP Yoshinobu Yamamoto (3.19 xFIP across 91.2 innings) will take on Padres SP Randy Vasquez (4.83 xFIP in 77.2 innings) on the mound.

Yamamoto has only allowed more than 3 earned runs in one of his starts during the 2026 season. According to Baseball Savant, the right-hander has registered a 3.31 expected ERA (xERA), which ranks in the 74th percentile.

Meanwhile, Vasquez has yielded at least 4 earned runs in two of his last three starts, including allowing 6 earned runs in just 3.1 innings against the Texas Rangers in his most recent outing. Opposing hitters have tallied a .297 expected batting average (xBA) against Vasquez in 2026.

Despite Friday’s result, the Dodgers and Padres are at opposite ends of the spectrum offensively. According to FanGraphs, Los Angeles ranks first in wRC+ (118), while San Diego comes in dead last with a wRC+ of 88.

The Dodgers averaged 6.0 runs per game across their three-game sweep against the Minnesota Twins.

Dodgers vs. Padres Winner Payout, Over/Under – Saturday, June 27

The Dodgers enter Saturday's game as a road favorite against the Padres, returning a 1.47x payout if they win outright via PrizePicks Team Picks.

Here are the full payouts for the Dodgers vs. Padres game on PrizePicks.

• Spread: Los Angeles Dodgers -1.5 (1.81x payout)
• Over/Under: 7.5 (1.75x payout on Over)
• Game Winner Payout: Dodgers 1.47x | Padres 2.56x

Make your Dodgers vs. Padres prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Dodgers vs. Padres Prediction on Winner – 6/27/26

Here are the key game stats and trends behind our Dodgers vs. Padres prediction on the winner for Saturday, June 27.

Lock in your Dodgers vs. Padres prediction on PrizePicks now.

• The Dodgers are 6-4 in their last 10 meetings against the Padres, including winning two of the last three contests in San Diego.
• The Dodgers lead the majors in batting average (.261) and slugging percentage (.437), while ranking second in runs (424) behind only the Washington Nationals (439).
• Vasquez has a 0-2 record to go along with a 4.58 ERA and 10 strikeouts in four career appearances against the Dodgers.
• Plus, he has recorded a 6.47 xERA in 2026, which ranks in just the second percentile.
• Meanwhile, Yamamoto has tallied a 37.0% hard-hit rate allowed in 2026, ranking in the 60th percentile. As a team, the Padres have registered a 40.4% hard-hit rate.
• The Dodgers have been victorious in six of Yamamoto’s last six starts.

Dodgers vs. Padres Picks, Player Stats for PrizePicks: 6/27/26

Here are the top Dodgers vs. Padres picks to target on Saturday, June 27. Today’s MLB picks for PrizePicks include Yoshinobu Yamamoto and Jackson Merrill.

Dodgers SP Yoshinobu Yamamoto vs. Padres: 6 Strikeouts 

• Yamamoto has registered at least 7 strikeouts in five of his last eight starts.
• The Dodgers’ right-hander has tallied a 4.9% walk rate this season, ranking in the 96th percentile.
• Yamamoto has 1 or fewer earned runs in five of his last six starts. Another lengthy start should help his potential to stack strikeouts.
• The Dodgers’ ace limited the Padres to just 1 earned run on 3 hits across 7.0 innings on May 18.

Add Yoshinobu Yamamoto to your PrizePicks Lineup now.

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Padres OF Jackson Merrill vs. Dodgers: 5 Hitter Fantasy Score 

• Merrill is hitting .105 (2-for-19) in his last five games with 2 runs scored.
• The Padres’ centerfielder is 0-for-6 with a strikeout in six career plate appearances against Yamamoto.
• Merrill has recorded a .238 xBA this season, which ranks in the 32nd percentile.
• Across his last 10 contests, Merrill has racked up just two multi-hit games.

Add Jackson Merrill to your PrizePicks Lineup now.

Make Dodgers vs. Padres Picks on PrizePicks

The Dodgers got off to a rough start in their three-game set against the Padres. However, with their ace Yoshinobu Yamamoto on the mound, Los Angeles could bounce back in a big way on Saturday.

Don’t wait until the first pitch — make your Dodgers vs. Padres picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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