Cubs vs. Rockies Prediction, MLB Picks for Wednesday, June 10

June 10, 2026

MLB
AP Photo/Paul Beaty

Cubs vs. Rockies is set for first pitch at 8:40 p.m. ET on Wednesday, June 10, with the Cubs returning a 1.56x payout if they win, via PrizePicks.

The Cubs will turn to the struggling SP Shota Imanaga (4-6, 4.74 ERA), who has given up 26 runs over his last 21.2 innings. The Rockies will deploy their own underwhelming option in SP Michael Lorenzen (2-8, 8.01 ERA), who has allowed 23 runs (22 earned) across his last 16.2 innings.

Below, we’ll break down our Cubs vs. Rockies prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Cubs vs. Rockies Prediction, Winner Payout, Over/Under – Wednesday, June 10

The Cubs lineup scuffled again Tuesday during a 7-3 loss. It marked the sixth time over the last eight games that they’ve scored 3 or fewer runs. During that span, they went 2-6. Tuesday’s loss dropped their road record to 14-18 for the season.

The Rockies continue to be a different team at home than on the road. Their 13-19 home record is still bad, but their lineup is much more productive at Coors Field (.751 OPS vs. .675 on the road). 

That should come as little surprise, considering that Coors Field has the highest park factor in the majors, per Baseball Savant.

Cubs vs. Rockies Winner Payout, Over/Under – Wednesday, June 10

The Cubs enter Wednesday’s game as a road favorite against the Rockies, returning a 1.56x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cubs vs. Rockies game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

  • Spread: Chicago Cubs -1.5 (1.81x payout)
  • Over/Under: 12.5 runs (1.88x payout Over)
  • Game Winner Payout: Cubs 1.56x | Rockies 2.32x
Make your Cubs vs. Rockies prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live as of writing and is subject to change.


Cubs vs. Rockies Prediction on Over/Under – 6/10/26

Here are the key game stats and trends behind our Cubs vs. Rockies prediction on the over/under for Wednesday, June 10.

  • The main reason why Imanaga has performed poorly lately is that he gave up 12 home runs over his last four starts. That was also a problem for him last season, when he allowed 1.9 HR/9.
  • According to Baseball Savant, opponents have a .541 xSLG against Imanaga’s four-seamer. Last year, they recorded a .594 xSLG off that pitch.
  • Lorenzen has a 6.14 xERA and hasn’t finished with a mark below 4.48 since 2022.
  • The veteran righty also gives up too many long balls, ceding 1.6 HR/9.
  • Lorenzen has seen his strikeout rate plummet to 15.9%, and it wasn’t high to begin with. For his career, he only has a 19.4% strikeout rate.
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Cubs vs. Rockies Player Picks, Stats for PrizePicks – 6/10/26

Here are some top Cubs vs. Rockies picks to target on Wednesday, June 10. Today's MLB picks for PrizePicks include Cubs 1B Michael Busch and Rockies C Hunter Goodman.

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Cubs 1B Michael Busch vs. Rockies: 2.5 Hits + Runs + RBI

  • Busch went 1-for-3 with a solo home run and 1 walk in Tuesday’s loss.
  • Across his last 10 games, the 28-year-old is 13-for-38 (.342) with 6 RBI and 3 runs scored.
  • Even though his power numbers are down compared to last season, Busch still has a 10.9% barrel rate and has a career 13.3% figure.
  • Lorenzen’s 9.6% barrel rate and 46.5% hard-hit rate allowed are both on pace to be the highest of his career.
  • Busch has a lifetime .357 wOBA and .229 ISO against right-handed pitchers.
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Rockies C Hunter Goodman vs. Cubs: 6.5 Hitter Fantasy Score

  • Goodman also started off this series on a high note, going 1-for-3 with a home run, 2 RBI, 2 runs scored, and 2 walks on Tuesday.
  • With 7 home runs over his last 12 games, the slugging catcher now has a .283 ISO. Last year, he registered a .243 ISO on his way to hitting 31 home runs.
  • Goodman has a 15.1% barrel rate and has never finished a season lower than 10.4%.
  • Of the 17 home runs that Imanaga has allowed, 12 of them have come off the bat of a right-handed hitter. Last year, 27 of 31 were hit by righties.
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We could be looking at a high-scoring affair with Imanaga facing off against Lorenzen at Coors Field on Wednesday. Busch will try to continue his recent hot streak, while Goodman has the potential to hit for power again.

Don’t wait until the first pitch — make your Cubs vs. Rockies picks on PrizePicks now and earn real money if you’re right.

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Mike Barner has been covering fantasy sports since 2007. He specializes in the NBA, NFL, and MLB. He is a two-time finalist for the Fantasy Sports Writers Association Basketball Writer of the Year award and won the 2021-22 FSGA NBA Experts Champions league. In addition to PrizePicks, Mike has written for Sports Illustrated, RotoWire, SportsLine, and more.