The Chicago Cubs (17-9) will square off against the Los Angeles Dodgers (17-9) for the second game of a three-game series on Saturday, April 25, at 7:15 p.m. ET on FOX.
On Friday night, the Cubs pulled out a 6-4 victory on the back of a 2-run HR by SS Dansby Swanson in the top of the ninth inning.
Entering Saturday’s contest, the Dodgers possess a 56% implied probability to win, via PrizePicks Team Picks.
Below, we'll break down our Cubs vs. Dodgers prediction and picks for Saturday’s MLB showdown, including the run line, over/under, and key player picks for PrizePicks.
Make your picks for Cubs vs. Dodgers on PrizePicks now.
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Cubs vs. Dodgers Prediction, Winner Payout, Over/Under – Saturday, April 25
For the second game of the series, it will be the Cubs SP Colin Rea (3.58 xFIP across 2 starts, 3 relief appearances, and 24.0 IP) and the Dodgers SP Roki Sasaki (5.19 xFIP across 4 starts and 17.2 IP) getting the ball.
After struggling in recent seasons, Rea is off to a solid start in 2026, ranking in the 70th percentile in xERA (3.38) and 89th percentile in walk rate (5.2%), per Baseball Savant. In his most recent start on Monday, Rea held the Philadelphia Phillies to 1 ER while logging 5 Ks at home.
Chicago’s bats have been red-hot to start the new season, registering the second-best wRC+ (124), second-best wOBA (.352), and seventh-best ISO (.165), via FanGraphs.
Following a stint as a reliever in the Dodgers’ championship run last season, Sasaki hasn’t been able to find his footing as a starter, residing in the 16th percentile in xERA (5.70) and 18th percentile in walk rate (14.1%) through four starts this year.
Los Angeles’ lineup is arguably the only order that's been better than Chicago, notching the best wRC+ (128), best wOBA (.361), and second-best ISO (.193) in baseball.
Cubs vs. Dodgers Winner Payout, Over/Under – Saturday, April 25
The Dodgers enter Saturday’s game as home favorites, returning a 1.66x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Cubs vs. Dodgers game on PrizePicks.
- Spread: Dodgers -1.5
- Over/Under: 9.5
- Game Winner Payout: Cubs - 2.08x | Dodgers - 1.66x
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Team Picks data is live at the time of writing and is subject to change.
Cubs vs. Dodgers Prediction on Over/Under – 4/25/26
Here are the key game stats and trends behind our Cubs vs. Dodgers prediction on the total runs for Saturday, April 25.
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- While Rea has formidable metrics to begin 2026, he was in the 24th percentile in xERA (4.55), 18th percentile in xBA (.261), and 18th percentile in barrel rate (10.3%) across 27 starts in 2025.
- Dealing with injuries to their rotation and bullpen, the Cubs’ relievers are currently posting the 11th-worst xERA (4.49) and ninth-worst HR/9 (1.19).
- In addition to Sasaki permitting 3 or more ER in two of his last three starts, he’s also in the 29th percentile in xBA (.266), 37th percentile in barrel rate (9.1%), and 30th percentile in hard-hit rate (43.6%).
- Just a season ago, the Dodgers had the best wRC+ (125), second-best wOBA (.347), and best ISO (.214) at home.
- Meanwhile, the Cubs boasted the third-best wRC+ (110), third-best wOBA (.328), and third-best ISO (.185) when playing as the visitors in 2025.
- Additionally, Los Angeles had the fifth-highest rate of hitting the over (54.8%) when playing at Dodger Stadium last year.
- Winds are blowing out to right field at Dodger Stadium on Saturday, which could aid the left-handed hitters against two right-handed starters.
Cubs vs. Dodgers Player Picks, Stats for PrizePicks: 4/25/26
Here are top Cubs vs. Dodgers picks to target on PrizePicks for Saturday, April 25. Today’s MLB picks for PrizePicks include OF Ian Happ and 3B Max Muncy.
Cubs OF Ian Happ vs. Dodgers Projection: 5.5 Hitter Fantasy Score
- Ian Happ enters Saturday’s matchup on an eight-game hitting streak. Throughout that eight-game stretch, he’s totaled 2 multi-hit outings, 3 HRs, and 6 RBIs.
- In the early going this year, Happ owns a 142 wRC+, .379 wOBA, and .260 ISO across his first 112 PAs.
- With Happ operating as a switch-hitter, it’s worth noting he had a 123 wRC+, .344 wOBA, and .193 ISO when facing righties in 2025.
- Sasaki tallied a 6.49 xFIP, 1.55 WHIP, and 1.93 HR/9 to left-handed sluggers last year. He’s recording a 5.85 xFIP, 1.97 WHIP, and 2.13 HR/9 in that split to start this year.
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Dodgers 3B Max Muncy vs. Cubs Projection: 5.5 Hitter Fantasy Score
- Max Muncy is in stellar form, generating at least 1 hit in seven of his last 10 outings. He’s totaled 3 multi-hit performances, 3 doubles, 4 HRs, and 5 RBIs during that 10-game span.
- The hard-hitting infielder is producing a 167 wRC+, .418 wOBA, and .303 ISO across his first 101 PAs in 2026.
- During the 2025 campaign, Rea recorded a 4.57 xFIP, 1.56 WHIP, and 1.62 HR/9 to lefties.
- Muncy crushed right-handed pitching to the tune of a 157 wRC+, .396 wOBA, and .247 ISO last season.
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The Cubs and Dodgers are two of the best teams in baseball to begin the 2026 season, and there will be two inconsistent starters on the mound for Saturday’s meeting. Who will come away with a victory in the primetime spotlight?
Don’t wait until the first pitch happens — make your Cubs vs. Dodgers picks on PrizePicks now and earn real money if you’re right.
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