Cardinals vs. Giants is set for first pitch at 8:10 p.m. ET on Monday, September 7 on NBC and Peacock, with the Giants favored and returning a 1.72x payout if they win via PrizePicks.
The Cardinals begin this series with SP Michael McGreevy (6-9, 3.97 ERA) on the mound. The Giants will counter with SP Logan Webb (8-8, 4.21 ERA), who was hammered for 9 runs over 2 innings in his last start.
Below, we’ll break down our Cardinals vs. Giants prediction and picks for Monday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
Make your Cardinals vs. Giants prediction and picks on PrizePicks now.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Cardinals vs. Giants Prediction, Winner Payout, Over/Under – Monday, September 7
At 59-85, the Giants are well on their way to finishing with one of the worst records in baseball. They have a -75 run differential, which is the sixth-lowest mark.
Their lineup has been a problem, ranking 19th in wRC+ (99), per FanGraphs. The pitching staff isn't missing many bats, registering the fourth-lowest strikeout rate (19.7%).
The Cardinals are four games out of the final Wild Card spot in the National League. Interestingly enough, they've been better on the road (38-34) than at home. St. Louis owns a modest 97 wRC+ on offense and a 20.7% K-rate from the pitching ranks.
Cardinals vs. Giants Winner Payout, Over/Under – Monday, September 7
The Giants enter Monday’s game as a home favorite against the Cardinals, returning a 1.72x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Cardinals vs. Giants game on PrizePicks.
Make your Cardinals vs. Giants prediction on spread or over/under on PrizePicks Team Picks.
Team Picks data is live as of writing and is subject to change.
Cardinals vs. Giants Prediction on Winner – 9/7/26
Here are the key game stats and trends behind our Cardinals vs. Giants prediction on the winner for Monday, September 7.
- The Cardinals have the third-highest road OPS (.740) in baseball. At home, their OPS is only .666.
- The Giants have a .704 OPS at home compared to a .725 mark on the road.
- St. Louis is 4-2 during its nine-game road trip, averaging 7.8 runs during that span.
- This is the first home game for the Giants after their seven-game road trip that saw them play in Atlanta, Pittsburgh, and New York (3-4 record).
- San Francisco only has 26 saves, which is the second fewest in the majors. Part of the problem is that their bullpen has a 1.42 WHIP.
Lock in your Cardinals vs. Giants prediction today on PrizePicks.
Cardinals vs. Giants Picks, Player Stats for PrizePicks: 9/7/26
Here are top Cardinals vs. Giants picks to target on Monday, September 7. Today's MLB picks for PrizePicks include 1B Rafael Devers and 1B Alec Burleson.
Stack your MLB lineup on PrizePicks today and win real money if you’re right!
Giants 1B Rafael Devers vs. Cardinals: 1.5 Hits + Runs + RBI
- Devers is one of the hottest hitters in baseball, going 22-for-54 (.407) with 9 home runs, 21 RBIs, and 16 runs scored over his last 14 games.
- The former Red Sox standout has launched 35 home runs during his first full campaign with the Giants, marking the third time over the last four years he's reached 33+.
- Devers owns a .261 ISO and a .358 wOBA in San Francisco.
- McGreevy has a 3.97 ERA on the year, but his 5.36 xERA indicates that he's far from thriving. Across his last eight starts, he put up a 1.68 WHIP and allowed 33 runs (30 earned) over 39.1 innings.
Add Rafael Devers to your PrizePicks MLB lineup now!
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Cardinals 1B Alec Burleson vs. Giants: 6.5 Hitter Fantasy Score
- After never posting more than 78 RBIs in a season, Burleson has already driven in 103 runs this year.
- The 27-year-old is a good contact hitter, maintaining a 17.0% strikeout rate. That could make him an especially difficult matchup for Webb, who has just a 19.2% K-rate.
- Burleson has a lackluster .737 OPS at home but an .878 OPS on the road.
- However, he has dominated righties to the tune of a .401 wOBA and a .226 ISO. Against LHP, Burleson has respective marks of .240 and .086.
Add Alec Burleson to your PrizePicks MLB lineup now!
Make Cardinals vs. Giants Picks on PrizePicks
The Cardinals try to pull out a win on the road against a Giants team that has been among the worst in baseball. Burleson has the potential to continue his productive hitting against right-handed pitchers, while Devers could extend his torrid stretch at the plate against the underwhelming McGreevy.
Don’t wait until the first pitch — make your Cardinals vs. Giants picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on MLB game winners, spreads, and over/unders, now available in 36 states.
Stay locked in on Playbook for daily MLB predictions, picks, and news all the way through the 2026 MLB season.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
