Cardinals vs. Dodgers Prediction, MLB Picks for Wednesday, September 2

The St. Louis Cardinals (69-70) vs. the Los Angeles Dodgers (82-56) is set for 10:10 p.m. ET on Wednesday, September 2, with the Dodgers returning a 1.36x payout to win, via PrizePicks Team Picks.

The first game of this series may come as a shock. The Cardinals’ offense came out early, and Dodgers SP Eric Lauer allowed 7 earned runs in just 3.0 innings. The Cardinals’ offense continued, scoring 13 runs—their second-best total this season. The Dodgers attempted to come back by scoring 3 runs in the ninth, but it wasn’t enough, as the Cardinals secured the 13-8 win.

Below, we'll break down our Cardinals vs. Dodgers prediction and picks for Wednesday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.

Make your Cardinals vs. Dodgers prediction on PrizePicks now!

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Cardinals vs. Dodgers Prediction, Winner Payout, Over/Under – Wednesday, September 2

St. Louis doesn't have the best outlook as the regular season enters its final month. Before this series against the Dodgers, the Cardinals lost seven of their last nine games. The offense has been struggling, ranking 26th in wOBA (.285) since August 21, while the pitching has been brutal with a 4.59 in xERA (27th) in the split.

Although the Cardinals have a losing record, the playoffs are within reach, sitting only four games out of the third Wild Card spot. PrizePicks Team Picks gives St. Louis a 22.22x payout to qualify for the playoffs, signifying a tall mountain to climb.

At the time of this writing, the Cardinals have not named a starting pitcher for today’s matchup. The Dodgers will counter with SP Yoshinobu Yamamoto (3.32 xFIP in 158.0 IP, 24 starts).

Brewers SP Jacob Misiorowski has grabbed all the headlines among National League pitchers, but don't let that overshadow an excellent season from Yamamoto.

He ranks fourth in the National League in xERA (3.04) and sixth in WAR (4.1). If it weren't for Misiorowski’s stellar season, Yamamoto might be generating some Cy Young buzz. 

He was nearly untouchable in August, posting a 1.95 xERA and a 3.29 xFIP, both of which were his monthly bests.

Is it time to be concerned about the Dodgers? On July 31, the Dodgers were an MLB-best 69-41. Since then, they are just 13-14. However, no one in the National League West was able to capitalize, and Los Angeles still has a 10.0-game cushion in first place.

This is one of the top lineups in baseball, but they haven’t looked the part of late. Some of the order's best hitters have stumbled, including DH Shohei Ohtani (.268 xBA) and SS Mookie Betts (.276 xBA) with low xBAs in August.

However, the pitching might be good enough to carry the load, especially in October. SP Tarik Skubal has a 2.79 xERA since being acquired, SP Blake Snell sports a 1.81 xERA, and SP Tyler Glasnow boasts a 1.87 xERA since returning from the IL.

Cardinals vs. Dodgers Winner Payout, Over/Under – Wednesday, September 2

The Dodgers enter Wednesday’s game as home favorites, returning a 1.36x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cardinals vs. Dodgers game on PrizePicks.

Make your Cardinals vs. Dodgers prediction on the spread or over/under on PrizePicks Team Picks to earn real money—available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Cardinals vs. Dodgers Prediction on Spread – 9/2/26

Here are the key game stats and trends behind our Cardinals vs. Dodgers prediction on the run line for Wednesday, September 2.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

• The Dodgers have won five of Yamamoto’s last seven starts.
• Los Angeles' ace has not allowed a run to the Cardinals in 11.0 career innings.
• Yamamoto has some of the best control in baseball, with a 5.9% walk rate that ranks in the 90th percentile. The Cardinals struggle to get free passes, with an 8.4% walk rate (23rd).
• The Cardinals are allowing an 8.6% barrel rate, ranking 27th since August 21. Now they face the Dodgers, who sit seventh with an 8.4% barrel rate.

Lock in your Cardinals vs. Dodgers prediction on PrizePicks before the first pitch.

Cardinals vs. Dodgers Picks, Player Stats for PrizePicks – 9/2/26

Here are the top Cardinals vs. Dodgers picks to target on PrizePicks for Wednesday, September 2. Today’s MLB picks for PrizePicks include Ivan Herrera and Freddie Freeman.

Cardinals DH Ivan Herrera vs. Dodgers: 5 Hitter Fantasy Score

• Herrera has been slumping with just 4 hits in his last 19 at-bats (.211).
• The Cardinals’ designated hitter is 0 for 5 with 2 strikeouts against Yamamoto.
• Herrera has an underwhelming 5.4% barrel rate, which ranks in the 27th percentile. Yamamoto should have the advantage, allowing a 6.3% barrel rate that ranks in the 69th percentile.
• In Dodger Stadium, Herrera has struggled with a .214 BA and .762 OPS.

Add Ivan Herrera to your PrizePicks lineup now.

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Dodgers 1B Freddie Freeman vs. Cardinals: 5.5 Hitter Fantasy Score

• Freeman has been hot recently, with a .373 xwOBA and a .400 BABIP since August 25.
• The Dodgers’ first baseman has a .400 BABIP since August 25, ranking 35th. The Cardinals are 30th by allowing a .369 BABIP during that time.
• The Cardinals’ pitching staff has struggled against left-handed hitters this season, sitting 20th in barrel rate (8.1%) and last in hard-hit rate (43.1%).

Add Freddie Freeman to your PrizePicks lineup now.

Make Cardinals vs. Dodgers Picks on PrizePicks

The Dodgers suffered a brutal loss when the starting pitching was hammered early in yesterday's game. That may not be a problem with Yamamoto on the mound tonight, who has yet to allow a run to the Cardinals over two starts.

Don’t wait until the first pitch—make your Cardinals vs. Dodgers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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