Cardinals vs. Dodgers Prediction, MLB Picks for Tuesday, September 1

Cardinals vs. Dodgers is set for first pitch at 10:10 p.m. ET on Tuesday, September 1, with the Dodgers favored and returning a 1.51x payout if they win, via PrizePicks.

With Dodgers SP Roki Sasaki (finger) on the injured list, SP Eric Lauer (8-6, 4.78 ERA) has moved back into the rotation and will take the mound for the first game of this series. The Cardinals will counter with SP Michael McGreevy (5-9, 3.86 ERA).

Below, we’ll break down our Cardinals vs. Dodgers prediction and picks for Tuesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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Cardinals vs. Dodgers Prediction, Winner Payout, Over/Under – Tuesday, September 1

The Dodgers (82-55) have one of the best records in baseball, while the Cardinals (68-70) are sitting in third place in the NL Central. A big reason for their disparity in records is their lineups. Per FanGraphs, the Dodgers have the second-highest wRC+ (109) in baseball, while the Cardinals rank 22nd (95) in that category.

The Cardinals have a lack of power in their lineup, posting a .140 ISO that puts them in 27th place in the majors. With DH Shohei Ohtani leading the way, the Dodgers are seventh with their .164 ISO.

What makes the Dodgers’ power even more dangerous is that they are a good contact-hitting team, posting the fourth-lowest strikeout rate (20.5%) in baseball.

Cardinals vs. Dodgers Winner Payout, Over/Under – Tuesday, September 1

The Dodgers enter Tuesday’s game as a home favorite against the Cardinals, returning a 1.51x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Cardinals vs. Dodgers game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!

Make your Cardinals vs. Dodgers prediction on spread or over/under on PrizePicks Team Picks — available in 36 states!

Team Picks data is live as of writing and is subject to change.

Cardinals vs. Dodgers Prediction on Winner – 9/1/26

Here are the key game stats and trends behind our Cardinals vs. Dodgers prediction on the winner for Tuesday, September 1.

• The Cardinals are 3-7 over their last 10 games. In those seven losses, they scored 4 or fewer runs five times.
• This is the first game of a nine-game homestand for the Dodgers. They are 40-26 in the friendly confines of Dodger Stadium this season.
• Los Angeles has a +153 run differential, compared to St. Louis having a run differential of -15.
• The Dodgers have the highest OPS in baseball against right-handed pitchers (.764).
• McGreevy is far from an overpowering pitcher, especially considering his 16.7% strikeout rate. Last season, his K-rate was even worse at 14.5%.

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Cardinals vs. Dodgers Picks, Player Stats for PrizePicks: 9/1/26

Here are top Cardinals vs. Dodgers picks to target on Tuesday, September 1. Today's MLB picks for PrizePicks include DH Shohei Ohtani and OF Joshua Báez.

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Dodgers DH Shohei Ohtani vs. Cardinals: 1.5 Total Bases

• Ohtani has 30 home runs, 18 of which have come off right-handed pitchers. Last season, 40 of his 55 homers were against righties.
• The star two-way player is slugging .561 at home compared to .505 on the road.
• Although McGreevy’s 3.86 ERA looks good, his 5.41 xERA indicates that he hasn't necessarily pitched that well. Opponents have recorded a 10.0% barrel rate against him.
• The Cardinals’ starter has allowed 20 home runs, 13 of which were launched by left-handed hitters. He's given up 33 home runs in his career — 22 to lefties

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Cardinals OF Joshua Báez vs. Dodgers: 4.5 Hitter Fantasy Score

• Báez hit 3 home runs in his first game in the majors. Since then, he is 6-for-50 (.120) with 2 home runs and a .182 OBP.
• The young slugger is having problems making contact, posting a 37.3% strikeout rate. That’s nothing new, given his 29.5% strikeout rate at Triple-A in 2026.
• Over his last 29 plate appearances, Báez posted 14 strikeouts and no walks.
• For his career, Lauer has limited right-handed hitters to a .322 wOBA. He's been right in line with that this year, ceding a .325 wOBA to righties.

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The Dodgers are in a favorable position to earn another victory with the struggling Cardinals arriving in Los Angeles. Ohtani has a great matchup against McGreevy that could lead him to rack up total bases. The same optimism can’t be had for Báez, who's striking out at an alarming rate.

Don’t wait until the first pitch — make your Cardinals vs. Dodgers picks on PrizePicks now and earn real money if you’re right.

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