The St. Louis Cardinals (29-22) and the Milwaukee Brewers (30-20) are set to begin a three-game series on Monday, May 25, at 2:10 p.m. ET. This will be the second series between the Cardinals and Brewers this season, with both teams winning one game apiece in the previous series.
Before the first pitch is thrown on Monday, the Brewers are massive home favorites with a 1.4x payout if they defeat the Cardinals, via PrizePicks Team Picks.
Below, we'll break down our Cardinals vs. Brewers prediction and picks for Monday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.
Make your Cardinals vs. Brewers picks on PrizePicks for today's game.
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Cardinals vs. Brewers Prediction, Winner Payout, Over/Under – Monday, May 25
In the series opener, it will be Cardinals SP Matthew Liberatore (4.24 xFIP across 10 starts and 51.2 IP in 2026) and Brewers SP Jacob Misiorowski (2.20 xFIP across 10 starts and 57 IP) squaring off on the bump.
Besides Liberatore having the worst WHIP (1.55) of his career since 2022, he’s sitting in the 11th percentile in xERA (5.64) and fifth percentile in xBA (.294), via Baseball Savant.
According to FanGraphs, the Cardinals have been one of the better lineups across the last 14 days, logging the sixth-best wRC+ (115), eighth-best wOBA (.334), and second-lowest strikeout rate (17.2%) during that span.
Misiorowski is one of the most exciting pitchers to watch right now, and his Baseball Savant page resembles the color of a strawberry, residing in the 95th percentile in xERA (2.30), 93rd percentile in xBA (.183), and 99th percentile in strikeout rate (39.3%). Among qualified pitchers, Misiorowski also has the highest average fastball velocity (99.7 MPH) in the league.
According to PrizePicks Team Picks, Misiorowski has the fourth-shortest payout to win the NL Cy Young (5.26x). Phillies SP Cristopher Sanchez (2.63x) is the current favorite, followed by Dodgers SP Shohei Ohtani (4.54x) and Pirates SP Paul Skenes (4.76x).
In the same 14-day sample used above, the Brewers’ bats haven’t been too shabby themselves, earning the 10th-best wRC+ (104), 12th-best wOBA (.320), and seventh-lowest strikeout rate (20.0%).
With both the Cardinals and Brewers fighting to win the National League Central as the top two teams in the division, Milwaukee has the lowest payout (1.92x) to win the division, via PrizePicks Team Picks.
Meanwhile, St. Louis has the third-lowest payout (7.69x) to win the NL Central, with the Chicago Cubs in second (3.03x).
Cardinals vs. Brewers Winner Payout, Over/Under – Monday, May 25
The Brewers enter Monday’s game as home favorites, returning a 1.4x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Cardinals vs. Brewers game on PrizePicks.
- Spread: Brewers -1.5 (1.88x payout)
- Over/Under: 7.5 (1.88x payout on Over)
- Game Winner Payout: Cardinals 2.77x | Brewers 1.4x
Make your Cardinals vs. Brewers prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Cardinals vs. Brewers Prediction to Win – 5/25/26
Here are the key game stats and trends behind our Cardinals vs. Brewers prediction on the winner for Monday, May 25.
Lock in your Cardinals vs. Brewers prediction on PrizePicks before the first pitch.
- Aside from Misiorowski being credited with a 4-2 record over his first 10 starts, the Brewers have secured the victory in three of his last four outings.
- In addition to his electric strikeout metrics, Misiorowski does a stellar job of limiting hard contact, residing in the 94th percentile in barrel rate (2.7%) and 81st percentile in hard-hit rate (32.7%).
- As for Liberatore, he’s in just the 28th percentile in strikeout rate (19.0%), 25th percentile in barrel rate (9.8%), and 22nd percentile in hard-hit rate (44.2%).
- Over his last eight starts, Liberatore has coughed up 4 or more ER in five appearances.
- Since the start of May, Milwaukee’s bullpen has been the more reliable unit, posting the second-best xERA (2.68) and third-lowest HR/9 (0.36) in that timeframe.
- On the other hand, St. Louis’ relievers have accrued the third-worst xERA (4.48) and eighth-highest HR/9 (1.03) since the start of May.
- The home team has won six of the last 10 head-to-head meetings between the Cardinals and Brewers.
Cardinals vs. Brewers Player Picks, Stats for PrizePicks – 5/25/26
Here are the top Cardinals vs. Brewers picks to target on PrizePicks for Monday, May 25. Today’s MLB picks for PrizePicks include Jacob Misiorowski and Jake Bauers
Brewers SP Jacob Misiorowski vs. Cardinals: 8.5 Pitcher Strikeouts
- While this is a lofty strikeout number, Misiorowski has racked up 9 or more Ks in six of his 10 starts in 2026 — including two of his last three.
- Although the Cardinals have the seventh-lowest strikeout rate (20.9%) on the season, they have the 14th-highest strikeout rate (22.1%) against right-handed pitching.
- St. Louis also carries the 11th-highest CSW rate (called + swinging strike rate; 27.6%) in the league.
- Misiorowski has slightly better strikeout splits on the road, but he’s still recording a monstrous 38.1% strikeout rate at home this season.
Add Jacob Misiorowski to your PrizePicks Lineup now.
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Brewers 1B Jake Bauers vs. Cardinals: 4.5 Hitter Fantasy Score
- Liberatore is producing reverse splits early in the season, allowing a .389 BABIP, 1.94 WHIP, and 3.97 HR/9 to lefties. He’s giving up a .314 BABIP, 1.44 WHIP, and 0.89 HR/9 to righties.
- Additionally, Liberatore is permitting a .350 BABIP, 1.50 WHIP, and 1.23 HR/9 on the road in 2026.
- Jake Bauers has been one of the Brewers’ better hitters against left-handed pitching despite being a lefty, registering a 119 wRC+, .342 wOBA, and .205 ISO in that split.
- Along with Bauers having at least 1 hit in nine of his last 10 outings, he’s totaled 5 multi-hit performances, 1 HR, 8 RBIs, 4 doubles, and 5 runs during that span.
Add Jake Bauers to your PrizePicks Lineup now.
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It’s an ultra-competitive race in the National League Central this season, and the Cardinals and Brewers are atop the division right now. Will Milwaukee extend their lead at the top with Misiorowski taking the mound on Monday?
Don’t wait until the first pitch happens — make your Cardinals vs. Brewers picks on PrizePicks now and earn real money if you’re right.
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