The first pitch of the matchup between the St. Louis Cardinals (51-47) and the Los Angeles Angels (39-61) is set for 10 p.m. ET on Monday, July 20, and the game can be viewed on ESPN. The Angels are favored and return a 1.81x payout to win via PrizePicks.
The Cardinals start the second leg of their six-game road trip and will try to rebound after losing two of three games to the Arizona Diamondbacks. The Angels, meanwhile, were able to snap their five-game losing streak on Sunday against the under-.500 Detroit Tigers.
Below, we'll break down our Cardinals vs. Angels prediction and picks for Monday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.
Make your Cardinals vs. Angels prediction on PrizePicks for tonight’s game.
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Cardinals vs. Angels Prediction, Winner Payout, Over/Under – Monday, July 20
The Cardinals will start Kyle Leahy (4.23 xFIP in 89.1 IP, 18 starts) on Monday.
Leahy has some great surface numbers, including a 3.73 ERA, but when you look deeper, a 5.37 xERA is concerning. He’s coming off two starts in which he didn’t allow any earned runs, but his last start against the Braves saw him go just 3 innings due to a rain delay.
The Cardinals have a young core that is showing promise. RF Jordan Walker is emerging as a star with a breakout season that includes winning the Home Run Derby, 1B Alec Burleson is on pace to have a career year, and SP Michael McGreevy is turning into an excellent pitcher with a 2.92 ERA.
The problem for the Cardinals is that they haven't found consistency. They've had extended winning and losing streaks, which have kept them around .500 for most of the campaign. They're currently tied for the final Wild Card spot with the Miami Marlins and Pittsburgh Pirates, and there are three other teams within two games of them.
The Angels will counter with Jose Soriano (3.76 xFIP in 111.0 IP, 20 starts) on the mound. Soriano had an incredible start to the season and was in the early American League Cy Young conversation. In his first 5 starts, he allowed just 1 earned run in his 37.2 innings, sporting a 2.85 xERA and 2.87 xFIP.
It’s gone downhill from there; over his last 13 starts, he has a 5.08 xERA and 4.10 xFIP. Soriano is just one piece of another disastrous season for the Angels.
The franchise has finished last in the American League West over the past three seasons and hasn't made the playoffs since 2014. Los Angeles is having another disappointing season and is the only team that has yet to get to 40 wins.
Cardinals vs. Angels Winner Payout, Over/Under – Monday, July 20
The Angels enter Monday’s game as home favorites against the Cardinals, returning a 1.81x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Cardinals vs. Angels game on PrizePicks.
- Spread: Los Angeles Angels -1.5 (2.63x payout)
- Over/Under: 8.5 (1.78x payout on Over)
- Game Winner Payout: Cardinals 1.92x | Angels 1.81x
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Team Picks data is live at the time of writing and is subject to change.
Cardinals vs. Angels Prediction on Over/Under – 7/20/26
Here are the key game stats and trends behind our Cardinals vs. Angels prediction on the run total for Monday, July 20.
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Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.
- Leahy is allowing a 10.9% barrel rate, which ranks in just the 11th percentile. The Angels excel in that category with an 8.7% barrel rate that's eighth in the league.
- Soriano’s 36.4% hard-hit rate is slightly above the league’s average in the 64th percentile, but the Cardinals will be a challenge, as their 41.1% hard-hit rate is fourth in MLB.
- There is a concerning contrast between Leahy's home and away performances. He has an excellent 2.94 ERA at Busch Stadium, but a 4.94 mark on the road.
- Soriano is allowing a .242 xBA (46th percentile), while the Cardinals’ .250 xBA is fourth in baseball.
- If these offenses don’t get to the starters, then they might take advantage of the below-average bullpens. The Cardinals’ relievers sit 18th in baseball with a 4.20 ERA, while the Angels are 24th at 4.58 ERA.
Cardinals vs. Angels Picks, Player Stats for PrizePicks: 7/20/26
Here are the top Cardinals vs. Angels picks to target on Monday, July 20. Today’s MLB picks for PrizePicks include Jordan Walker and Nolan Schanuel.
Cardinals RF Jordan Walker vs. Angels: 1.5 Hits + Runs + RBI
- Walker is having a breakout season, with his .285 xBA, .512 xSLG, and .464 xwOBAcon all being career highs.
- Walker has been getting more free passes lately; his 13.6% walk rate since July 2 ranks 28th. Soriano struggles with control, evidenced by his 11.4 BB-rate (18th percentile).
- The Cardinals' RF is one of the hardest hitters in the league, in large part due to a 79.2 MPH bat speed that’s in the 100th percentile and an average exit velocity of 94 mph that’s in the 98th percentile. That’s troubling for Soriano, who’s allowing an 88.1 MPH average exit velocity that occupies the 61st percentile.
- Soriano throws a sinker and curveball for a combined 59% of his pitches to right-handed batters. Walker excels against those pitches to the tune of a .298 xBA and .503 xSLG against the sinker and a .301 xBA and .539 xSLG when seeing the curveball.
Add Jordan Walker to your PrizePicks Lineup now.
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Angels 1B Nolan Schanuel vs. Cardinals: 5 Hitter Fantasy Score
- Schanuel has been one of baseball's hottest hitters recently, backed by a .480 wOBA since July 5 that ranks eighth in the league and a 16.7% walk rate that's ninth.
- That plate discipline could help against Leahy’s 8.5% walk rate (50th percentile).
- It’s difficult to get Schanuel to swing and miss; his 17.7% whiff rate resides in the 83rd percentile. It might be especially challenging for Leahy, who’s in the 24th percentile with a 21.8% whiff rate allowed.
- Lefties have a .309 BA against Leahy compared to a .224 BA for righties. Left-handed batters have hit 1.20 HR/9 against him (0.61 vs. RHH).
Add Nolan Schanuel to your PrizePicks Lineup now.
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The Cardinals will wrap up their road trip with a three-game series in Orange County. St. Louis holds a share of the third Wild Card slot and now gets to face Los Angeles, who's been the league’s punching bag all season. This might just be a great opportunity to stay firmly in that mix.
Don’t wait until the first pitch happens — make your Cardinals vs. Angels picks on PrizePicks now and earn real money if you’re right.
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