Brewers vs. Padres Prediction, MLB Picks for Wednesday, August 12

Brewers vs. Padres is set for first pitch at 4:10 p.m. ET on Wednesday, August 12, with the Brewers favored and returning a 1.78x payout if they win, via PrizePicks.

Both teams will turn to starting pitchers that they acquired at the trade deadline. The Brewers will deploy former Cardinals SP Dustin May (6-7, 4.30 ERA), while the Padres will roll with former Giants SP Robbie Ray (10-7, 3.24 ERA).

Below, we’ll break down our Brewers vs. Padres prediction and picks for Wednesday’s MLB clash, including the game winner, over/under, and key player picks for PrizePicks.

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Brewers vs. Padres Prediction, Winner Payout, Over/Under – Wednesday, August 12

Although they have only scored 4 runs while losing the first two games of this series, the Brewers generally have a more potent lineup than the Padres. Per FanGraphs, their 104 wRC+ ranks eighth in baseball. The Padres have a 98 wRC+ that puts them at 19th.

Milwaukee doesn’t hit a lot of home runs, ranking 26th in ISO (.144). What provides the Brewers with a significant boost to their lineup is their selectiveness at the plate. They only have a 21.4% strikeout rate, and their 10.7% walk rate is the second-highest mark in the sport.

Brewers vs. Padres Winner Payout, Over/Under – Wednesday, August 12

The Brewers enter Wednesday’s game as road favorites against the Padres, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Brewers vs. Padres game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!

Make your Brewers vs. Padres prediction on spread or over/under on PrizePicks Team Picks — available in 36 states!

Team Picks data is live as of writing and is subject to change.

Brewers vs. Padres Prediction on Winner – 8/12/26

Here are the key game stats and trends behind our Brewers vs. Padres prediction on the winner for Wednesday, August 12.

• Even after losing the first two games of this series, the Brewers are still 33-24 on the road this season. They're 15-9 overall since the All-Star break, too.
• Milwaukee hasn't lost three straight games since dropping all three matchups of a series against the Pirates, which included a doubleheader on July 11.
• Milwaukee boasts an excellent pitching staff, which ranks first in xERA (3.40) and third in WHIP (1.17).
• May faced the Padres twice already this season while a member of the Cardinals, allowing a total of 3 runs (2 earned) to go along with 16 strikeouts over 15 innings.

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Brewers vs. Padres Picks, Player Stats for PrizePicks: 8/12/26

Here are top Brewers vs. Padres picks to target on Wednesday, August 12. Today's MLB picks for PrizePicks include OF Fernando Tatis Jr. and OF Jackson Merrill.

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Padres OF Fernando Tatis Jr. vs. Brewers: 5.5 Hitter Fantasy Score

• Tatis is heating up as the playoffs approach, going 17-for-55 (.309) with 4 home runs and 5 doubles over his last 14 games. During that span, he also logged 7 walks to 6 strikeouts.
• Although the outfielder’s power numbers seem down on the surface, he has an 11.5% barrel rate and a 52.8% hard-hit rate. Those are largely on par with his career marks of 13.8% and 52.5%, respectively.
• Tatis has a 139 wRC+ at home, compared to a 93 wRC+ on the road.
• The trade from St. Louis to Milwaukee might not provide a boost to May. He has a 1.52 WHIP away from St. Louis this year.

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Padres OF Jackson Merrill vs. Brewers: 1.5 Hits + Runs + RBI

• Merrill is one of the hottest hitters in baseball, going 16-for-43 (.372) with 4 home runs, 14 RBI, and 10 runs scored over his last 11 games.
• During his recent hot streak, the 23-year-old only had a 20.0% strikeout rate. That’s an improvement over his season mark of 23.9%.
• Merrill has an 11.6% barrel rate, which is right in line with his career figure of 11.9%.
• For his career, Merrill has a .348 wOBA and a .220 ISO against right-handed pitchers. Lefties have limited him to a .294 wOBA and a .120 ISO.

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The Brewers will try to avoid their first three-game losing streak in about a month when they face the Padres on Wednesday. Even if the Brewers come away with the win, Tatis and Merrill could have productive performances at the plate.

Don’t wait until the first pitch — make your Brewers vs. Padres picks on PrizePicks now and earn real money if you’re right.

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