Brewers vs. Cubs Prediction, MLB Picks for Tuesday, September 1

The Milwaukee Brewers vs. Chicago Cubs game is set for a first pitch at 7:40 p.m. ET on Tuesday, September 1 at Wrigley Field, with the Cubs favored and returning a 1.72x payout with a win, via PrizePicks. 

The Cubs (78-60) rolled past the Brewers (85-53) in Monday’s opener, 17-3, to bounce back from a series defeat to the Reds.

Milwaukee still owns a comfortable seven-game advantage over Chicago atop the NL Central. The Brewers captured the first four matchups with the Cubs but have lost each of the past three meetings.

Below, we'll break down our Brewers vs. Cubs prediction and picks for Tuesday's MLB game, including the winner, over/under, and key player picks for PrizePicks.

Make your picks for Brewers vs. Cubs on PrizePicks now.

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Brewers vs. Cubs Prediction, Winner, Over/Under – Tuesday, September 1

The Cubs remain tied with the red-hot Phillies for the top Wild Card spot in the National League. Both teams own a substantial five-game edge over the Padres, so barring a meltdown, both Chicago and Philadelphia will be playing October baseball.

The Brewers have allowed 24 runs in the past two losses to the Rangers and Cubs. Chicago went deep nine times last night, capped off by a trio of bombs from 3B Alex Bregman. All nine Cubs in the starting lineup eclipsed their HRR (hits/runs/RBI) prop, while pinch-hitter Michael Conforto also went deep in the rout.

Chicago sits atop the league in wOBA (.340), while Milwaukee isn’t far behind at .325. The Cubs are ahead of the Brewers in xSLG and xwOBA, but Milwaukee is several points ahead in xBA, according to Baseball Savant. 

Craig Counsell’s squad leads MLB with 742 runs scored, a +56 run advantage over the Brewers and 72 more runs than the NL West-leading Dodgers.

Brewers vs. Cubs Winner, Over/Under – Tuesday, September 1

The Cubs enter Tuesday’s game as home favorites against the Brewers, returning a 1.72x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Brewers vs. Cubs game on PrizePicks.

Play the Brewers vs. Cubs winner or over/under on PrizePicks Team Picks to earn real money — available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Brewers vs. Cubs Prediction on Winner – 9/1/26

Here are the key game stats and trends behind our Brewers vs. Cubs prediction on the winner for Tuesday, September 1.

Lock in your Brewers vs. Cubs prediction on PrizePicks now.

• The Brewers are 9-2 in Robert Gasser’s last 11 starts since going 0-4 in his first four outings.
• The Cubs have dropped each of SP Matthew Boyd’s last three starts, including the past two on the road.
• Boyd faced Milwaukee in the playoffs twice last season with dramatically different results. He allowed 6 runs in the opening inning of Game 1 but didn’t yield a run in nearly 5 innings in a Game 4 win.
• Chicago has posted the top wOBA against left-handed pitching (.359), along with the best wRC+ against southpaws (129).
• The Brewers have lost the first two games of a road series three times in 21 tries.
• Since July 26, Milwaukee has compiled a 9-2 record against left-handed starting pitchers.

Brewers vs. Cubs Picks, Player Stats for PrizePicks: 9/1/26

Here are top Brewers vs. Cubs picks to target on Tuesday, September 1. Today’s MLB picks for PrizePicks include DH Christian Yelich and P Matthew Boyd.

Brewers DH Christian Yelich vs. Cubs: 1.5 Hits + Runs + RBI

• Yelich is 3-for-14 against Boyd lifetime, but two of those hits were a double and a home run.
• In the last two losses, Yelich is hitless in 7 at-bats with 4 strikeouts. He closed August with 10 outings of 0-of-3 or worse at the plate.
• Yelich has finished with fewer than 1 HRR in 14 of the last 20 road contests.
• The 2018 NL MVP owns career lows in xBA at .236 and xwOBA at .315, according to Baseball Savant. 

Add Christian Yelich to your PrizePicks lineup now.

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Cubs P Matthew Boyd vs. Brewers: 4 Strikeouts

• Boyd posted 3 or fewer strikeouts in his first four August starts before striking out five batters at Arizona last Wednesday.
• The southpaw’s K-rate dropped from 21.4% last season to 19% in 2026.
• In his first four home starts, Boyd averaged 6.75 strikeouts, but he's compiled 11 Ks in his last four outings at Wrigley.
• The Brewers own the ninth-lowest K-rate against left-handed pitchers in MLB at 21.2%.

Add Matthew Boyd to your PrizePicks lineup now.

Make Brewers vs. Cubs Picks on PrizePicks

The Cubs struck first in a huge way with 9 home runs in Monday’s rout of Milwaukee. Can the Brewers bounce back tonight at Wrigley Field and end their short two-game slide?

Don’t wait until lock — make your Brewers vs. Cubs picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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