Brewers vs. Astros Prediction, MLB Picks for Sunday, May 31

The Milwaukee Brewers (34-21) vs. the Houston Astros (27-33) is set for 2:10 p.m. ET on Sunday, May 31, with the Brewers returning a 1.44x payout to win, via PrizePicks.

In the first game of the series, the Brewers erased a 3-run deficit by scoring 4 unanswered runs, including 1 run in the 10th inning to secure a 5-4 win. The Astros responded with a dominant performance highlighted by SS Jeremy Pena going 3 for 5 in the 9-2 win. Sunday is the rubber match, with the Brewers sending flame-throwing SP Jacob Misiorowski to the mound.

Below, we'll break down our Brewers vs. Astros prediction and picks for Sunday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.

Make your Brewers vs. Astros picks on PrizePicks for today's game.

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Brewers vs. Astros Prediction, Winner Payout, Over/Under – Sunday, May 31

The Brewers will start their star SP Jacob Misiorowski (2.01 xFIP across 11 starts and 64 IP in 2026). There is a reason why Misiorowski has the second-lowest payout to win the National League Cy Young on PrizePicks Team Picks. He's looked nearly unhittable, allowing just 1 earned run over his last 31.1 innings. He is the hardest-throwing starter in baseball, proven by 57 pitches eclipsing 100 mph.

The Brewers have charged up the National League Central standings. They have won 8 of their last 11 games. Milwaukee has gone from half a game behind first place to enjoying a four-game lead in the NL Central. The Brew Crew's 18-7 record and 2.87 xERA are the best marks in the league this month.

The Astros will counter with SP Tatsuya Imai (4.92 xFIP across 6 starts and 23 IP in 2026). The rookie pitcher out of Japan is coming off his best start, going 6 scoreless innings against the Rangers. Control has been an issue, as he’s given up a minimum of 3 walks in five of his six starts.

The Astros are on one of their best runs, as this is the first time they’ve had seven wins in any 10-game stretch this season. Despite still sitting below .500, Houston is only three games behind first place in the AL West.

Brewers vs. Astros Winner Payout, Over/Under – Sunday, May 31

The Brewers enter Sunday’s game as road favorites, returning a 1.44x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Brewers vs. Astros game on PrizePicks.

• Spread: Brewers -1.5 (1.78x payout)
• Over/Under: 7.5 (1.85x payout on Over)
• Game Winner Payout: Brewers 1.44x | Astros 2.63x

Make your Brewers vs. Astros prediction on the spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Brewers vs. Astros Prediction on Spread – 5/31/26

Here are the key game stats and trends behind our Brewers vs. Astros prediction on the run line for Sunday, May 31.

Lock in your Brewers vs. Astros prediction on PrizePicks before the first pitch.

Data used in this article is from Baseball Savant or FanGraphs.

• Misiorowski is the league’s top strikeout pitcher, leading with a 40.3% strikeout rate. The Astros have been prone to strikeouts recently, ranking 19th with a 22.9% strikeout rate in May.
• Imai's 17.5% walk rate is among the worst in the league, ranking in the second percentile. That could negatively impact him against a Brewers offense that is third with an 11.0% walk rate.
• The Miz produces many swings and misses, with a 39.0% whiff rate that sits in the 99th percentile. The Astros rank 19th with a 26.0% whiff rate in MLB.
• The Astros have one of the worst bullpens in the league, ranking last with a 4.92 xFIP.
• Misiorowski has been slightly better on the road with a 1.66 ERA compared to 1.91 at home.

Brewers vs. Astros Picks, Player Stats for PrizePicks – 5/31/26

Here are the top Brewers vs. Astros picks to target on PrizePicks for Sunday, May 31. Today’s MLB picks for PrizePicks include William Contreras and Yordan Alvarez.

Brewers C William Contreras vs. Astros: 5 Hitter Fantasy Score

• Contreras has been hot recently, as his 16 hits since May 15 are the fifth-most in the league.
• Contreras’ 44.3% hard-hit rate ranks in the 64th percentile, which could be a significant advantage over Imai’s 50.3% hard-hit rate allowed (second percentile).
• The Brewers’ catcher rarely walks away empty-handed, with a 13.3% strikeout rate that ranks in the 90th percentile.
• Imai’s strikeouts have taken a significant dip, going from 13 strikeouts in his first 8.1 innings of the season to 10 strikeouts in his last 15 innings.

Add William Contreras to your PrizePicks Lineup now.

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Astros DH Yordan Alvarez vs. Brewers: 5.5 Hitter Fantasy Score

• It will be a power-on-power matchup between Alvarez and Misiorowski. The Astros designated hitter leads the league in xSLG (.754) and xBA (.346).
• If one batter can connect on Miz's 100+ mph fastball, it could be Alvarez. He has just an 18.4% whiff rate on fastballs, with a 1.215 OPS and a .486 wOBA.
• Alvarez has been sending the ball into the stands, as his 6 home runs since May 15 top the league.
• According to Statcast park factors, Daikin Park features the fourth-most home runs for left-handed hitters among ballparks. This benefits the left-handed-hitting Alvarez, who has a 29.0% home run-to-fly-ball ratio at home compared to 21.6% on the road.

Add Yordan Alvarez to your PrizePicks Lineup now.

Make Brewers vs. Astros Picks on PrizePicks

The Brewers took the first game of the series with a 5-4 win in extra innings, but the Astros responded on Saturday to force a rubber match. Milwaukee will send up its ace, Jacob Misiorowski, in this pivotal series finale.

Don’t wait until the first pitch — make your Brewers vs. Astros picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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