Blue Jays vs. Cubs Prediction, MLB Picks for Thursday, August 6

The Toronto Blue Jays and Chicago Cubs will square off in a makeup game from a three-game series they had in June on Thursday, August 6, at 2:20 p.m. ET. Before the first pitch is thrown in Thursday’s contest, the Blue Jays are favored on the road with a 1.78x payout to secure a victory on PrizePicks Team Picks.

The Blue Jays and Cubs split the first two games of the series on June 19 and June 20. The series finale between Toronto and Chicago on June 21 was postponed, so they are playing the contest on Thursday, August 6, to finish the series.

Below, we'll break down our Blue Jays vs. Cubs prediction and picks for Thursday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.

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Blue Jays vs. Cubs Prediction, Winner Payout, Over/Under – Thursday, August 6

For Thursday’s matchup, it will be Blue Jays SP Dylan Cease (2.67 xFIP across 119.1 IP) and Cubs SP David Peterson (4.15 xFIP across 101.0 IP) squaring off on the mound.

Cease has been one of the most dominant pitchers in 2026, ranking in the 94th percentile or better in xERA (2.77), xBA (.189), and strikeout rate (36.2%), per Baseball Savant. The only chink in Cease’s armor is his 23rd percentile walk rate (10.6%).

Ahead of Thursday’s outing, Cease has the second-lowest payout to win the AL Cy Young (2.5x) on PrizePicks Team Picks.

Peterson hasn’t experienced the same success on the bump as Cease this season, residing in the 24th percentile or worse in xERA (5.02), xBA (.275), and strikeout rate (18.8%). In his first six starts for the Cubs, Peterson has given up at least 1 HR in five of them.

It’s been a struggle at the plate for the Blue Jays over the last month, as they have the seventh-worst wRC+ (85), fourth-worst wOBA (.290), and third-worst ISO (.125) during that span, per FanGraphs. Meanwhile, not many teams have been swinging better than the Cubs in the last 30 days, posting the fourth-best wRC+ (119), second-best wOBA (.344), and seventh-best ISO (.177).

Blue Jays vs. Cubs Winner Payout, Over/Under – Thursday, August 6

The Blue Jays enter Thursday’s game as a road favorite against the Cubs, returning a 1.78x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Blue Jays vs. Cubs game on PrizePicks.

Make your Blue Jays vs. Cubs prediction on the spread or over/under on PrizePicks Team Picks to earn real money — available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Blue Jays vs. Cubs Prediction on Over/Under – 8/6/26

Here are the key game stats and trends behind our Blue Jays vs. Cubs prediction on the run total for Thursday, August 6.

• Despite Peterson’s struggles this season, Cease surrendered 1 or fewer ER in four of his five starts in June.
• Cease does a fantastic job limiting hard contact, sitting in the 89th percentile in barrel rate (4.8%) and 86th percentile in hard-hit rate (32.8%).
• On the road, Cease has a 2.73 xFIP, 0.99 WHIP, and 0.48 HR/9.
• Toronto’s bullpen also has the 10th-best xFIP (3.95) and 4th-best HR/9 (0.76) in the last month.
• The Blue Jays have achieved the over in only 3 of their last 10 games.
• Against left-handed pitchers, Toronto has the worst wRC+ (79), worst wOBA (.282), and fifth-worst ISO (.126) in 2026.

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Blue Jays vs. Cubs Picks, Player Stats for PrizePicks: 8/6/26

Here are the top Blue Jays vs. Cubs picks to target on Thursday, August 6. Today’s MLB picks for PrizePicks include Dansby Swanson and Myles Straw.

Cubs SS Dansby Swanson vs. Blue Jays: 3.5 Hitter Fantasy Score

• Swanson has just a 94 wRC+ and .307 wOBA against right-handed pitchers in 2026.
• Of Swanson’s 426 PAs this season, 232 have come in the No. 9 spot in the lineup.
• Cease boasts a 2.24 xFIP, 1.03 WHIP, and 36.5% strikeout rate against righties, compared to a 3.01 xFIP, 1.12 WHIP, and 35.9% strikeout rate against lefties.
• Swanson has gone hitless in five of his last eight appearances.

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Blue Jays RF Myles Straw vs. Cubs: 3 Hitter Fantasy Score

• When facing lefties in 2026, Straw has a 54 wRC+, .247 wOBA, and .115 ISO.
• Straw is in danger of being subbed out for a left-handed outfielder if the Cubs deploy a right-handed reliever.
• During July, Straw tallied just a 30 wRC+, .213 wOBA, and .108 ISO.
• Peterson has permitted 3 or fewer hits in three of his last four starts.

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The Blue Jays and Cubs are making up a game of a three-game series they had scheduled in June on Thursday, August 6. Runs could be tough to come by with Cease on the mound for Toronto and Peterson finding his footing for Chicago.

Don’t wait until the first pitch happens — make your Blue Jays vs. Cubs picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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