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Marquee players didn’t disappoint on Thursday Night Football to get Week 3 underway, as RB Bijan Robinson, WR Drake London, WR Christian Watson, and WR Matthew Golden all had notable outings. That could be a sign of things to come when Week 3 NFL games kick off on Sunday, September 27.
With plenty of stars in action today, which players stand out for NFL picks across Sunday’s contests?
Below, we'll bring you our best Week 3 NFL picks for DFS and PrizePicks, where you can predict More or Less on player stats to earn real money!
Make your Week 3 NFL predictions and picks on PrizePicks!
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Week 3 NFL DFS Picks for PrizePicks – Sunday, September 27
Here are the top Week 3 NFL DFS picks to target on PrizePicks for Sunday, September 27. Today’s NFL picks include Josh Allen, Parker Washington, Breece Hall, George Kittle, and Derrick Henry.
Stats in this article are courtesy of PFF or Sumer Sports unless stated otherwise.
Bills QB Josh Allen vs. Chargers: 240.5 Pass Yards
- QB Josh Allen has thrown for at least 248 yards in back-to-back games to begin the season.
- The Buffalo Bills are allowing Allen to cook more under new head coach Joe Brady, ranking fifth in neutral pass rate (59.3%), per RBSDM.
- Among 29 QBs with 50 or more dropbacks this season, Allen has the second-most yards per attempt (9.7).
- Along with the Los Angeles Chargers allowing 253 or more passing yards to Cardinals QB Jacoby Brissett and Raiders QB Kirk Cousins to begin the year, they are 25th in dropback EPA (0.25) and dropback success rate (52.0%) allowed.
Pick Josh Allen + Bills to win on PrizePicks!
Jaguars WR Parker Washington vs. Patriots: 62.5 Receiving Yards
- WR Parker Washington has tallied at least 83 receiving yards in each of his first two starts this season.
- Dating back to last season, Washington has posted 83 or more receiving yards in six straight games (including the playoffs).
- Of the 105 WRs with 25 or more routes run in 2026, Washington has the second-highest target share (36.7%) and third-most yards per route run (3.93).
- While WR Brian Thomas Jr. could see plenty of CB Christian Gonzalez in coverage, Washington should avoid him with a team-high 52.9% slot rate.
Pick Parker Washington + Jaguars to cover the spread on PrizePicks!
Jets RB Breece Hall vs. Lions: 84.5 Rush + Receiving Yards
- RB Breece Hall looks healthy to begin the 2026 campaign, accruing 92 or more rushing + receiving yards in back-to-back games.
- The New York Jets are 6.5-point road underdogs vs. the Lions on PrizePicks, likely leading to more pass-catching opportunities for Hall.
- Among RBs with 5 or more targets this season, Hall has the most yards per reception (11.3) and most yards per route run (2.72).
- The Detroit Lions’ defense is 28th in dropback success rate (53.3%) and 26th in rushing success rate (46.2%) to begin the year.
Add Breece Hall to your PrizePicks lineup now!
49ers TE George Kittle vs. Cardinals: 45.5 Receiving Yards
- TE George Kittle exploded for 80 yards and a TD on 4 receptions in Week 2, and it was just his second game back from an Achilles injury.
- WR Mike Evans is questionable with a hip injury for Week 3, and WR Demarcus Robinson — who was filling in for rookie WR De’Zhaun Stribling — sustained a sprained ankle in Week 2 and is now out.
- QB Brock Purdy is tied for the fourth-most yards per attempt (8.8) while recording the highest adjusted completion percentage (89.1%) among QBs with 50 or more dropbacks this season.
- The Arizona Cardinals are 21st in dropback EPA (0.21) and 19th in dropback success rate (47.1%) through the first two weeks.
Pick George Kittle + 49ers to win on PrizePicks!
Ravens RB Derrick Henry vs. Cowboys: 90.5 Rush Yards
- RB Derrick Henry has rushed for 100 or more yards in five of his last six starts, including his 144-yard outing in Week 1 against the Indianapolis Colts.
- Even with new offensive coordinator Declan Doyle, the Baltimore Ravens are 28th in neutral pass rate (48.4%) across the first two weeks.
- When looking at RBs with at least 25 rushing attempts this year, Henry has the fourth-most yards per attempt (5.3), fifth-most yards after contact per attempt (3.9), and seventh-most runs of 10-plus yards (4).
- The Dallas Cowboys’ defense is currently 29th in rushing success rate allowed (48.3%).
Pick Derrick Henry + Ravens to cover the spread on PrizePicks!
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Make Week 3 NFL Picks on PrizePicks
The impending Jets-Lions and Ravens-Cowboys matchups in Week 3 stand out as potential high-scoring environments. Within those games, will Hall thrive as a runner and receiver against Detroit, and will Henry gash Dallas’ run defense in Brazil?
Ahead of Sunday’s action, it's time to lock in your NFL picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
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