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Week 3 of the college football season features three games on Friday, beginning with #5 Miami taking on Wake Forest at 7:30 p.m. ET on ESPN.
Before wrapping things up with Portland State and #21 Oregon at 10:30 p.m. ET, the most notable matchup includes #22 Houston and #13 Texas Tech in a Big 12 showdown on FOX at 8 p.m. ET.
Even with a lack of games to watch, there will still be plenty of marquee players taking the field on Friday night.
Below, we'll bring you our top Week 3 CFB DFS picks for PrizePicks, where you can predict More or Less on college football player stats to earn real money if you're right!
Make your Week 3 college football predictions and picks on PrizePicks!
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Week 3 CFB DFS Picks for PrizePicks – Friday, September 18
Here are the top Week 3 CFB DFS picks to target on PrizePicks Player Picks for Friday, September 18.
Today’s college football picks include Malachi Toney, J'Koby Williams, Kam Shanks, and Dante Moore.
Miami WR Malachi Toney vs. Wake Forest: 101.5 Rec Yards
- After racking up 234 receiving yards on 12 receptions in Miami’s season opener, Toney tallied 96 receiving yards in Week 2 against Florida A&M.
- However, Toney went from playing 32 passing-down snaps in Week 1 to only 13 passing-down snaps in a lopsided Week 2 win.
- Among college wideouts with 15+ targets, Toney has the eighth-most yards per reception (20.6) and the most yards per route run (7.5), per PFF.
- Although Wake Forest is 2-0 to begin the 2026 campaign, its defense is in the 38th percentile in EPA/pass (0.3) and the 17th percentile in pass success rate allowed (60.0%), via Game on Paper.
Add Malachi Toney + Miami to cover the spread to your PrizePicks lineup now!
Texas Tech RB J’Koby Williams vs. Houston: 2.5 Recs
- Dating back to last season’s College Football Playoff quarterfinal against Oregon, Williams has caught 5+ passes in two of his last three starts.
- Williams began the 2026 season with 8 receptions for 57 yards against Abilene Christian.
- Besides posting the fourth-most targets (10) among college RBs, Williams has the 16th-highest route rate (81.8%) at the position.
- With Houston sitting in the 40th percentile in EPA/pass (0.2) and 81st percentile in EPA/rush (-0.2), Texas Tech may be more inclined to throw in a pivotal conference game.
Add J'Koby Williams + Texas Tech to win to your PrizePicks lineup now!
Wake Forest WR Kam Shanks vs. Miami: 18.5 Longest Rec
- Across Wake Forest’s first two games, Shanks is averaging only 11.8 yards per reception.
- Out of 197 college receivers with 10 or more targets, Shanks’ 11.8 yards per reception is only 123rd.
- Shanks’ longest reception on the season is 27 yards, and that came against an Akron defense that is in the 20th percentile in EPA/pass (0.5).
- Meanwhile, Miami’s defense is ranked in the 79th percentile in EPA/pass (-0.2).
Add Kam Shanks + Wake Forest to cover the spread to your PrizePicks lineup now!
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Oregon QB Dante Moore vs. Portland State: 229.5 Pass Yards
- Even with Oregon favored by 57.5 at home against Portland State, the Ducks need a convincing win following their upset loss to Oklahoma State in Week 2.
- While Moore aired it out for only 191 passing yards against Oklahoma State, he had 378 in the season opener against Boise State.
- Despite Oregon’s woes to begin the year, it's still in the 87th percentile in passing success rate (49.3%) and the 80th percentile in EPA/pass (0.2).
- Of the college QBs with at least 50 dropbacks in 2026, Moore is 26th in yards per attempt (8.8).
Add Dante Moore + Oregon to win to your PrizePicks lineup now!
Make Week 3 College Football Picks on PrizePicks
There’s a trio of college football games on the docket for Friday, including #22 Houston and #13 Texas Tech taking part in a Big 12 bout. Across the three games, which players are worth targeting on PrizePicks?
Ahead of tonight's action, it's time to lock in your college football picks on PrizePicks to earn real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
Stay locked in on Playbook for daily college football predictions, picks, and news every day, all the way through the National Championship Game.
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