Best MLB Home Run Picks Today – Friday, September 4

With a new weekend on the horizon, the MLB schedule contains a whopping 16 matchups due to the Detroit Tigers and Cleveland Guardians playing a day-night doubleheader. With that and various other big-time showdowns taking place, there could be ample chances for a bunch of home runs to be hit. 

Here at PrizePicks, we have plenty of home run projections on the board to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.

Let’s dive into some of the most-picked MLB home run projections for Friday, September 4, including what makes each player a potential target for home run predictions. 

Make your MLB home run picks for Friday, September 4 on PrizePicks now.  

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Best MLB Home Run Picks Today – Friday, September 4

There’s finally someone with 40+ home runs on the year, as Philadelphia Phillies DH Kyle Schwarber crossed over the threshold late last month. Chicago Cubs CF Pete Crow-Armstrong is right on his heels at 39 as he chases down an MVP award, and there’s a solid group of players flashing the pop in their bats elsewhere.

Of course, doing it is much more difficult than saying it. Although some things can’t be changed by the hitter, like ballpark dimensions, weather, and who’s throwing on the mound, certain batters optimize their launch angles, swing speeds, and more to give them better outlooks to hit a long ball.  

Which players could be in good positions to swat a homer on Friday? Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. Home runs can only be selected as “More” than 0.5. 

Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at the time of writing.

1. Phillies DH Kyle Schwarber
2. Cubs CF Pete Crow-Armstrong
3. Rays 3B Junior Caminero
4. Orioles 1B Pete Alonso
5. Pirates 2B Brandon Lowe
6. Astros DH Yordan Alvarez
7. White Sox SS Colson Montgomery
8. Cardinals RF Jordan Walker

Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

Rays 3B Junior Caminero

Rays vs. Rangers – 8:05 p.m. ET

Rangers Starting Pitcher: Kumar Rocker

MLB Weather Report: Played in a dome

• After clubbing 45 home runs in 2025, Caminero has returned with an impressive 37 to date and also has both a .249 ISO and a 144 wRC+, cementing his status as an elite hitter.
• Already a quick swinger before, Caminero has increased his average bat speed from 77.2 mph in 2024 to 78.5 last year and a blistering 79.7 this year. He owns an 86.1% fast-swing rate.
• The 23-year-old infielder resides in the 95th percentile in average exit velocity (93.0 mph) and the 93rd percentile in xSLG (.493).
• Rocker is known to dish out jacks to opposing hitters, surrendering 1.54 HR/9 last season and 1.25 in 2026.
• The former No. 3 overall MLB Draft pick allows a 40.3% hard-hit rate (34th percentile). 

Add Junior Caminero to your PrizePicks lineup now.

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Pirates 2B Brandon Lowe

Angels vs. Pirates – 6:40 p.m. ET

Angels Starting Pitcher: Ryan Johnson

MLB Weather Report: 78 degrees, 33% chance of rain, 4 mph west-southwest wind

• Lowe has established a nice floor for himself as a power threat, owning an ISO of .212 or better in each year dating back to 2023. 
• The veteran second baseman is maximizing his swing path, as his 32.3% squared-up contact rate is his best in three total years of tracking.
• Despite being on the wrong side of 30, Lowe remains in the 79th percentile or higher in hard-hit rate (45.8%), barrel rate (11.9%), and average exit velocity (91.0 mph).
• Johnson has made 17 appearances for the Angels and given up 1.99 HR/9, also raising his fly ball rate from 42.2% in the first half of the season to 53.5% in the second half.
• The 24-year-old righty’s peripherals are poor; he’s in the 10th percentile or worse in barrel rate (10.7%) and strikeout rate (16.5%), among others. 

Add Brandon Lowe to your PrizePicks lineup now.

Cardinals RF Jordan Walker

Cardinals vs. Rockies – 8:40 p.m. ET

Rockies Starting Pitcher: Ryan Feltner

MLB Weather Report: 89 degrees, clear skies, 6 mph south wind

• 2026 has seen Walker take his game to a whole new level, evidenced by a 13.5% barrel rate and a 22.0% blast-contact clip.
• Not many — if any — players swing harder than the breakout right fielder. Walker’s 79.2 mph average bat speed and 85.3% fast-swing rate are both outstanding.
• Even with the second half of his season being imperfect, Walker remains an 89th-percentile batter when it comes to hard-hit rate (48.9%) and a 90th-percentile player in xSLG (.484). 
• Removing a sample of 21 batted-ball events in his brief cup of coffee in 2021, this is the first time Feltner has ever allowed a double-digit barrel rate (10.5%). 
• Feltner’s four-seam fastball gets thrown 28.0% of the time and leads to a .569 SLG for opposing hitters. Walker performs quite well when facing that offering, owning a .519 SLG on the year. 

Add Jordan Walker to your PrizePicks lineup now.

Make MLB Home Run Picks on PrizePicks

If you’re making MLB home run picks on Friday, you can’t say there aren’t enough options out there. With 16 games to choose from, stars galore give fans a chance to correctly predict who will go yard to bring in the first weekend of September baseball in 2026.

Don’t wait until first pitch — make your MLB home run picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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