Coming off thrilling Week 1 victories, both the Detroit Lions and Buffalo Bills look to bring some flair to the Thursday Night Football stage in Week 2. Ahead of kickoff at 8:15 p.m. ET, Buffalo is favored by 5.5 points on PrizePicks.
Given the high-powered nature of these offenses, there may be plenty of points scored in this one. There’s no shortage of big-time names taking the field for either side, leaving the door open for touchdowns galore under the bright lights. Who could reach the end zone on Thursday?
Below, we'll highlight our best Lions vs. Bills TD scorer picks for PrizePicks in NFL Week 2, including three players who could reach the end zone on Thursday night.
Make your Lions vs. Bills TD predictions on PrizePicks now.
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Lions vs. Bills Anytime TD Scorer Picks for Thursday Night Football Week 2 – Thursday, September 17
As Thursday’s game approaches, there are double-digit options for fans to choose from when making predictions on touchdown scorers.
Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”
Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.
Lions RB Jahmyr Gibbs: 0.5 Anytime TDs (Goblin)
- One week into the 2026 NFL season, there’s a clear leader for both rush attempts (29) and first downs on the ground (14). The Lions certainly didn’t back down from embracing giving RB Jahmyr Gibbs every opportunity to do damage against the New Orleans Saints.
- After logging 300+ touches in consecutive seasons, Gibbs had 34 last Sunday and managed to produce 186 yards from scrimmage.
- According to SumerSports, Gibbs ranked fourth among all RBs a season ago with a 17.09% target share.
- Buffalo’s run defense was absolutely dreadful in 2026, sitting second-to-last with an EPA/play mark of 0.049 allowed (RBSDM).
- In Week 1 against the Houston Texans, the Bills ceded 0.030 EPA/run, ranking just 24th leaguewide.
- The 2025 Bills surrendered more fantasy points to the RB position than all but six teams, largely thanks to giving up more TDs on the ground (18) than anyone.
Add Jahmyr Gibbs + Lions to cover the spread to your PrizePicks lineup now.
Lions WR Amon-Ra St. Brown: 0.5 Anytime TDs (Demon)
- Matching Gibbs’ involvement as an NFL leader after Week 1, WR Amon-Ra St. Brown is tops in the business in both targets (14) and receptions (10).
- St. Brown is tied for first place in red-zone targets (4) entering Week 2.
- Out of all WRs with 100+ routes run last season, the former fourth-round pick was third in targets per route run (0.30) and fourth in target share (31.27%).
- The star wideout scored twice against the Saints and found pay dirt six times in his first four outings of 2025.
- St. Brown is a game-breaking threat on short routes, going 9-for-12 on targets of fewer than 10 air yards in Week 1. He racked up 723 of those yards a year ago, per NFL Pro, #2 at the WR position.
- Buffalo struggled to contain Houston QB C.J. Stroud, ceding a 52.1% dropback success rate (24th).
Add Amon-Ra St. Brown + Lions to win to your PrizePicks lineup now.
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Bills RB James Cook: 0.5 Anytime TDs (Goblin)
- While Detroit owned just a 7.7% missed tackle rate in Week 1 and was great in that regard last year, RB James Cook is a rare breed. The standout Bills halfback ripped off 1,050 rushing yards after contact in 2025, fourth at his position.
- Cook combined for 32 all-purpose regular-season TDs in 2024 and 2025.
- The Georgia product has produced triple-digit rush yards over expected in every season since 2023, peaking at 346 (+1.1 per carry) in 2025.
- Despite having to share carries with QB Josh Allen, Cook maintained a 47.3% red-zone rush rate a campaign ago, slotting inside the top 20 among all players.
- The Lions struggled with red-zone run defense this past season, sitting 25th with an average of 0.10 EPA/play allowed.
- Given that RB Ty Johnson is banged up again, Cook could receive plenty of work after logging an 88.9% share of backfield touches. According to Sharp Football Analysis, that was fourth for RBs in Week 1.
Add James Cook + Bills to cover the spread to your PrizePicks lineup now.
PrizePicks Flash Sale: DJ Moore Rec Yards for Thursday Night Football
Ahead of Thursday Night Football, PrizePicks is running a Flash Sale on Bills WR DJ Moore. The prized offseason pickup’s receiving yards projection is still decreased from Taco Tuesday, lowering his projection from 57.5 to 34.5.
In his Buffalo debut, Moore logged 8 targets and hauled in 5 passes for 100 yards and a score. His performance against Houston put him on the map as a top target for Allen, with replicating that production on the TNF stage being his next challenge.
Use PrizePicks promo code PLAYBOOK for Week 2. New users Play $5, Get $150 for Thursday Night Football.
Make Lions vs. Bills Picks on PrizePicks
Thursday Night Football’s 54.5-point total on PrizePicks hints at the possibility of several touchdowns being scored for Detroit and Buffalo. With players like Gibbs, St. Brown, and Cook suiting up, electric stat lines could follow.
Don’t wait until kickoff — make your Lions vs. Bills picks on PrizePicks now and earn real money if you’re right.
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