The Houston Astros vs. Seattle Mariners game is set for a first pitch at 4:10 p.m. ET on Monday, April 13, with Seattle entering as a 1.53x payout to win, via PrizePicks.
The Mariners seek a four-game sweep of the Astros this afternoon at T-Mobile Park. Seattle entered this series on a five-game skid but has scored 23 runs in the first three victories against Houston.
Below, we'll break down our Astros vs. Mariners prediction and picks for Monday's MLB game, including the winner, over/under, and key player picks for PrizePicks.
Make your picks for Astros vs. Mariners on PrizePicks now.
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Astros vs. Mariners Prediction, Winner Payout, Over/Under – Monday, April 13
It’s been a disappointing start for both these AL West squads, especially Seattle, who was one win away from the World Series last October.
The Mariners failed to win any of the first four series before capturing this set against Houston. Seattle scored 3 or fewer runs in eight of nine games before this series. The M’s plated 9, 8, and 6 runs to pick up their first three-game winning streak.
The Astros won five consecutive games towards the end of March but are in the midst of a seven-game losing streak. Houston’s offense scored 8 or more runs in five of its six wins, and it has yet to grab a victory when compiling fewer than 5 runs.
Houston’s pitching hasn't been great, giving up an average of 8.2 runs per game during this seven-game slide.
Astros vs. Mariners Winner Payout, Over/Under – Monday, April 13
The Mariners enter Monday’s game as a 1.53x payout against the Astros, returning a 2.38x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Astros vs. Mariners game on PrizePicks.
- Spread: Seattle Mariners -1.5 (2.17x payout)
- Over/Under: 7.5 (1.85x payout on Over)
- Game Winner Payout: Astros 2.38x | Mariners 1.53x
Play the Astros vs. Mariners winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Astros vs. Mariners Prediction on Winner – 4/13/26
Here are the key game stats and trends behind our Astros vs. Mariners prediction on the winner for Monday, April 13.
Lock in your Astros vs. Mariners prediction on PrizePicks before the line moves.
- The Mariners struck out only five times against Houston’s starting pitchers in the first three games.
- Astros P Mike Burrows has allowed a .421 average and .450 wOBA on his four-seam fastballs.
- We’ll see how C Cal Raleigh and 1B Josh Naylor respond against those fastballs. Raleigh is batting .125, and Naylor is hitting .143 when facing four-seamers.
- Houston’s pitching staff ranks last in MLB in wOBA at .380. On the flip side, Seattle sits third, allowing a wOBA of .286.
- In the first two road series finales, the Astros allowed 12 runs to the Athletics and 9 runs to the Rockies.
- The Astros have lost eight of the last nine meetings with the Mariners since last July.
Astros vs. Mariners Player Picks, Stats for PrizePicks – 4/13/26
Here are the top Astros vs. Mariners picks to target on PrizePicks for Monday, April 13. Today’s MLB picks for PrizePicks include SP George Kirby and DH Yordan Alvarez.
Mariners SP George Kirby vs. Astros Projection: 5.5 Strikeouts
- Kirby racked up 6 strikeouts in each of his first two starts before getting held to 4 Ks in a 3-2 loss at Texas.
- The Astros strike out at a 19.3% rate, which is the fourth-lowest in the league.
- Kirby tossed 6.0 scoreless innings and posted 7 Ks in his previous start against Houston last September.
- His highest whiff percentage pitch is the slider at 25%. Houston SS Carlos Correa whiffs at a 43.8% rate on sliders, while DH Yordan Alvarez sits at 28%.
Add George Kirby to your PrizePicks Lineup now.
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Astros DH Yordan Alvarez vs. Mariners Projection: 6.5 Hitter Fantasy Score
- Alvarez torched Seattle pitching for fantasy scores of 22 on Friday and 23 on Saturday.
- The slugger went hitless for the third time in six games, capped off by an 0-3 performance on Sunday.
- Alvarez is batting 3-for-16 with 6 strikeouts against Kirby, while picking up only one extra-base hit.
- In three of four series finales, Alvarez has eclipsed this fantasy score.
Add Yordan Alvarez to your PrizePicks Lineup now.
Make Astros vs. Mariners Picks on PrizePicks
Houston ends its disastrous road trip today, trying to avoid the sweep. Can the Mariners’ offense remain hot and beat the Astros once again?
Don’t wait until lock — make your Astros vs. Mariners picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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