Week 3 of the college football season brings an intriguing matchup between two top-10 teams when #8 Ole Miss hosts #7 LSU on Saturday, September 19, at 7:30 p.m. ET on ESPN. LSU is a 2.5-point road favorite and returns a 1.61x payout with a win, via PrizePicks.
Saturday’s contest marks LSU head coach Lane Kiffin’s first game against Ole Miss since leaving the Rebels late in the 2025 season.
LSU has gotten off to a 2-0 start, which included a 51-10 win against Clemson to begin the year. Meanwhile, Ole Miss began the season with a hard-fought 41-38 win against #23 Louisville in its season opener, then followed it up with a convincing victory against Charlotte in Week 2.
Below, we’ll break down an LSU vs. Ole Miss prediction and picks for Saturday night's game, including the spread, over/under, and player projections for PrizePicks.
Make your LSU vs. Ole Miss picks on PrizePicks now!
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#7 LSU vs. #8 Ole Miss Prediction, Spread, Over/Under – Saturday, September 19
Despite a 4-0 start to 2025, LSU had its fair share of low points and ended up firing head coach Brian Kelly in late October after losing to Texas A&M. LSU did play in the Texas Bowl after finishing the regular season 7-5 but lost 38-35 at the hands of Houston.
In late November, Kiffin took the LSU head coaching job, and the school made the veteran one of the highest-paid in the sport.
Tigers QB Sam Leavitt, who landed in Baton Rouge via the transfer portal, has struggled to start the 2026 campaign. He's completing 62.1% of his passes and has thrown just 2 TDs compared to 4 INTs in two games.
The former Arizona State QB registered 4 second-quarter turnovers in a 45-14 win against Louisiana Tech last week.
It’s been quite a week for Leavitt, who was initially listed as doubtful on Wednesday’s SEC availability report with an unknown injury. He was upgraded to questionable on Thursday before being completely removed from the report on Friday evening. As a result, Leavitt will play on Saturday.
According to ESPN’s Pete Thamel, members of the Ole Miss staff “weren’t convinced” that Leavitt’s appearance on the injury report was legitimate.
On the field, LSU is averaging 586.0 yards per game, third in the nation. However, they've still been iffy at times, posting a -0.01 EPA/pass.
Meanwhile, Ole Miss has already been tested early, outlasting Louisville in its season opener. The Rebels have been one of the SEC’s better passing teams thus far, averaging 353.0 passing yards through two games.
QB Trinidad Chambliss is under center for Ole Miss after a sensational campaign that led the Rebels to the College Football Playoff semifinals. Chambliss is off to a strong start again, completing 71.0% of his passes for 561 yards and 5 TDs while throwing just 1 INT.
Chambliss also boasts a dual-threat ability, evident in his 5.2 yards per carry. His legs could be an X-factor in extending plays against the Tigers throughout Saturday’s pivotal contest.
Ole Miss has tallied a 0.24 EPA/play mark on offense. As a result, the Rebels have put up 82 points across their opening two games.
LSU vs. Ole Miss Spread, Over/Under – Saturday, September 19
LSU enters Saturday’s game as a 2.5-point favorite against Ole Miss, via PrizePicks.
Here are the full payouts for LSU vs. Ole Miss, including winner payouts, the spread, and the over/under.
Make your LSU vs. Ole Miss prediction on the spread on PrizePicks.
PrizePicks data is live at the time of writing and is subject to change.
LSU vs. Ole Miss Prediction on Spread – 9/19/26
Here are the key game stats and trends behind our LSU vs. Ole Miss prediction on the spread for the Saturday, September 19 matchup.
- Ole Miss has a 3-0 record against the spread at home in the last three games against LSU in Oxford.
- The Rebels recorded a 24-19 home win against #4 LSU last season. Chambliss completed 23 of 39 passes for 314 yards and a TD while also adding 71 yards on the ground.
- According to Game on Paper, Ole Miss has recorded a 0.28 EPA/pass in two games, which ranks 12th in the nation.
- The Rebels have a third-down average distance of 5.89 yards, good for fourth in the country in 2026.
- LSU has registered just a 38.2% late-down success rate, sitting 121st in the nation.
- Lane Kiffin has a 5-6 record in his last 11 games against top-10 teams.
Lock in your LSU vs. Ole Miss prediction on PrizePicks before kickoff.
LSU vs. Ole Miss Picks, Player Stats for PrizePicks: 9/19/26
Here are the top LSU vs. Ole Miss picks to target on Saturday, September 19. Today’s college football picks for PrizePicks include QB Sam Leavitt and RB Kewan Lacy.
LSU QB Sam Leavitt vs. Ole Miss: 264.5 Pass Yards
- Leavitt completed 25 of 38 passes for 344 yards and a TD against Louisiana Tech in Week 2 but threw a trio of second-quarter INTs.
- The LSU signal-caller registered a 0.01 EPA/dropback with Arizona State last season, ranking 79th among QBs.
- In addition to committing 4 turnovers against Louisiana Tech, Leavitt was also sacked five times last week. Ole Miss tallied 3 sacks in its season-opening win against Louisville.
- The Ole Miss defense has surrendered a -0.01 EPA/pass, which ranks 38th in the nation.
Add Sam Leavitt + LSU to cover the spread to your PrizePicks lineup now.
Ole Miss RB Kewan Lacy vs. LSU: 83.5 Rush Yards
- Lacy carried the ball 13 times for 87 yards (6.7 yards per carry) and 2 TDs against Charlotte last week. As a team, the Rebels have recorded a 0.13 EPA/rush, good for 38th.
- The junior RB was added to the Walter Camp Preseason Watch List, which honors the top FBS player each season.
- LSU allowed 124.1 rushing yards per game last season, sitting seventh in the SEC.
- Lacy rushed for at least 84 yards in nine of his 15 games in 2025, including averaging 96.0 yards per game and 6.0 yards per carry in three CFP contests.
Add Kewan Lacy + Ole Miss to win to your PrizePicks lineup now.
Make LSU vs. Ole Miss Picks on PrizePicks
The stage is set for one of the most polarizing matchups on the college football schedule, as Lane Kiffin returns to Oxford for the first time since leaving the school last year. In a battle between two top-10 SEC powerhouses, can Ole Miss use its home field to its advantage in Saturday’s prime-time affair?
Don’t wait until kickoff — make your LSU vs. Ole Miss picks on PrizePicks now and earn real money if you’re right.
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