Yankees vs. White Sox Prediction, MLB Picks for Wednesday, July 29

Yankees vs. White Sox is set for first pitch at 7:40 p.m. ET on Wednesday, July 29, with the Yankees favored and returning a 1.63x payout if they win the bout on Prime Video and MLB Network, via PrizePicks.

After winning the first two games of the series, the Yankees will try to make it three in a row with ace SP Cam Schlittler (10-6, 2.07 ERA) on the mound. The White Sox will counter with a quality pitcher of their own in SP Davis Martin (9-5, 3.49 ERA).

Below, we’ll break down our Yankees vs. White Sox prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

Make your Yankees vs. White Sox prediction and picks on PrizePicks now.

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

Yankees vs. White Sox Prediction, Winner Payout, Over/Under – Wednesday, July 29

The Yankees need their pitching staff to step up with injuries hammering their lineup. They're currently without OF Aaron Judge (ribs), DH Giancarlo Stanton (calf), and OF Cody Bellinger (hamstring). With a lack of impact hitters, New York has scored 4 or fewer runs in six of the last seven games.

With that said, the staff has helped the Yankees still go 5-2 over that span.

Schlittler hasn’t needed much run support. Of his 22 starts, he allowed 2 or fewer earned runs 17 times. On the road, he has a 1.08 ERA and a 0.76 WHIP and hasn't given up more than 2 ER away from home since April 12 against the Rays. In that game, he permitted 3 ER.

Can the American League Central-leading White Sox find a way to put up runs against one of the best pitchers in the game?

Yankees vs. White Sox Winner Payout, Over/Under – Wednesday, July 29

The Yankees enter Wednesday’s game as a road favorite against the White Sox, returning a 1.63x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Yankees vs. White Sox game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!

Make your Yankees vs. White Sox prediction on spread or over/under on PrizePicks Team Picks — available in 36 states!

Team Picks data is live as of writing and is subject to change.

Yankees vs. White Sox Prediction on Winner – 7/29/26

Here are the key game stats and trends behind our Yankees vs. White Sox prediction on the winner for Wednesday, July 29.

• With losses in the first two games of this series, the White Sox are 4-6 over their last 10 games.
• The Yankees went 7-3 over their last 10 to move within 1.5 games of the Rays in the AL East.
• New York has played a road-heavy schedule but has thrived with a 35-23 record away from Yankee Stadium.
• Martin hasn't provided the White Sox with a lot of length, throwing 88 or fewer pitches in seven straight starts. He logged more than 5 innings in just three of them.
• If Martin can’t pitch deep again, the White Sox could be in trouble. Four of their relievers have pitched two of the last three days, which doesn’t even include RP Tyler Schweitzer, who still might not be available after throwing 38 pitches in Tuesday’s 3-2 loss.

Lock in your Yankees vs. White Sox prediction today on PrizePicks.

Yankees vs. White Sox Picks, Player Stats for PrizePicks: 7/29/26

Here are some of the top Yankees vs. White Sox picks to target on Wednesday, July 29. Today's MLB picks for PrizePicks include SP Cam Schlittler and 1B Paul Goldschmidt.

Stack your MLB Lineup on PrizePicks today and win real money if you’re right!

Yankees SP Cam Schlittler vs. White Sox: 4.5 Hits Allowed

• Schlittler has allowed 4 or fewer hits in three of his last four starts. For the season, he's ceded just 96 hits across 130.1 innings.
• The All-Star pitcher has given up more than 4 hits in just three of his 12 road starts.
• Schlittler misses many bats, generating a 30.5% strikeout rate, per FanGraphs.
• According to Baseball Savant, Schlitter throws his four-seamer 44.3% of the time. He has a 34.1% whiff rate on that offering.
• The White Sox swing and miss a lot, posting the seventh-highest strikeout rate (23.7%) in the majors.

Add Cam Schlittler to your PrizePicks MLB Lineup now!

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

Yankees 1B Paul Goldschmidt vs. White Sox: 1.5 Hits + Runs + RBI

• Across his last 23 games, Goldschmidt is 11-for-78 (.141) with only 2 home runs and 3 RBI.
• The veteran first baseman has a 1.052 OPS vs. left-handed pitchers, but only a .596 OPS against righties.
• After recording an 18.7% strikeout rate last year, Goldschmidt’s K-rate has jumped to 23.9% in 2026.
• The 38-year-old has seen his hard-hit rate drop to 37.4% — on pace to be the lowest mark of his career.

Add Paul Goldschmidt to your PrizePicks MLB Lineup now!

Make Yankees vs. White Sox Picks on PrizePicks

The Yankees may be in a favorable position to post their third straight victory with Schlittler on the mound. He's been great at limiting hits, especially on the road. This matchup might not be good news for Goldschmidt, though, since he has struggled mightily against righties.

Don’t wait until first pitch — make your Yankees vs. White Sox picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on Wednesday's MLB game winners, spreads, and over/unders, now available in 36 states.

Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.