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Yankees vs. Twins Prediction, Picks for 9/17/25: Avoid Luis Gil?

Yankees SP Luis Gil pitches during an MLB game.
AP Photo/Yuki Iwamura

Two American League teams in much different positions will square off tonight at 7:40 pm ET on Prime Video, as the Yankees — squarely in the playoff picture — take on the Twins.

Below, we'll give you our Yankees vs. Twins prediction and player picks for PrizePicks real money MLB game — pick players, predict More or Less on their stats, and win when you're right.

Let's lock in on this MLB showdown on Prime Video tonight.

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Yankees vs. Twins Prediction, & Preview

The Minnesota Twins have already been eliminated from playoff contention, stumbling to a 66-85 record. Their struggles are evident in a poor -83 run differential and a middling 37-39 mark at home this season. Against the Yankees, the Twins are just 2-3 this year and went a dreadful 2-9 last season against the Yankees.

The New York Yankees, meanwhile, sit five games back of the red-hot Toronto Blue Jays despite owning a stronger run differential (+123 compared to Toronto’s +88). They currently hold a slim two-game edge in the Wild Card race, making every contest critical down the stretch.

If the Yankees want to make a deep playoff run, they’ll need more from young right-hander Luis Gil, who will start tonight.

After missing the entire first half of the season with a lat strain, Gil has struggled to regain the form that once had him in the Rookie of the Year conversation. His ability to stabilize the rotation could prove pivotal.

On the other side, Taj Bradley has yet to rediscover the promise he once showed as a top arm in Tampa Bay’s rotation. Traded to the Twins after continued struggles with the long ball, Bradley has not looked like his younger self — his strikeout numbers have dipped, and home runs remain an issue.

That leaves two offenses that are top 11 in wOBA over the last 30 days vs. struggling pitchers — a potential spot to look toward hitters.

Whether you’re backing pitchers' earned runs or a hitter’s total bases, Monday's MLB slate is stacked with opportunities on PrizePicks to pick More or Less and cash in. Let's dig into player picks for this matchup.


Yankees vs Twins Picks: Wednesday, September 17

Here are the top MLB picks and predictions for PrizePicks today. Use this analysis to build your Lineups on PrizePicks MLB on Wednesday, September 17. Click to read more about each pick.

Yankees P Luis Gil Projection: 26.5 Pitcher Fantasy Score

  • Despite his impressive 2.83 ERA, Luis Gil's underlying metrics reveal cracks — his expected ERA (xERA) is a concerning 4.95, suggesting serious regression is looming
  • Over his last 117 batters faced, Gil has allowed a 10% barrel rate, 48% hard-hit rate, and a 31% fly ball rate — all red flags in terms of contact quality.
  • He’ll now face a Twins lineup that thrives against right-handed pitching: Minnesota owns a .277 BABIP, nearly 10% barrel rate, and a 45% hard-hit rate over their last 544 plate appearances vs. RHP.
  • Gil has averaged 30.6 fantasy points per start in his last five.

Twins DH Byron Buxton Projection: 6.5 Hitter Fantasy Score

  • In his last 77 plate appearances vs. right-handed pitching, Byron Buxton boasts a 40% fly ball rate, 63% hard-hit rate, and a massive 20% barrel rate.
  • Yankees SP Luis Gil is a RHP, surrendering a 5.30 xFIP to right-handed batters in 2024.
  • Buxton also has history against Gil, although a small sample in just 5 career at-bats, he’s already homered once.
  • Over those 77 plate appearances, Buxton owns a .315 wOBA and a .235 ISO, showcasing legit power and extra-base potential in this matchup.

Twins P Taj Bradley Projection: 2.5 Earned Runs Allowed

  • Twins SP Taj Bradley has struggled mightily in his recent outings since moving over from Tampa Bay. Over his last 21 innings pitched, he’s allowed 15 earned runs.
  • In his last 90 batters faced, Bradley has surrendered a 9.4% barrel rate, 47% hard-hit rate, and 29.7% fly ball rate.
  • The Yankees are poised to exploit him — across their last 593 PAs vs. righties, they carry a 16% barrel rate, 34% fly ball rate, and consistent power throughout the lineup.
  • Bradley has also struggled historically vs. the Yankees — in 65 career plate appearances against New York, he’s issued 9 walks, allowed 13 hits, and holds an extremely low 18.5% strikeout rate.

Make MLB Picks on PrizePicks Today

Wednesday's Yankees vs. Twins game provides plenty of MLB action, with two exploitable pitchers on the mound tonight.

Every game means more as we get into the heat of the MLB playoff positioning and divisional chase, and there's no better time to cash in on your MLB picks every day on PrizePicks.

Just build your MLB Lineup on PrizePicks with your favorite players, predict More or Less on stats like hits+runs+RBIs or pitcher fantasy score, and win real money when your picks are right. With new MLB Live inning by inning projections now available, you can get action on any game, at any time.

Stay locked in on the Playbook all season long for MLB DFS picks for PrizePicks every day.

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about the author

Shayne Trail is a Penn State Smeal College of Business graduate, and is the President of the @HallofFameFund (on X) where he positions historically profitable sports trends into investments. Shayne has expertise in all major sports, but writes mostly about NFL, MLB, and NBA for Playbook.

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