Yankees vs. Red Sox is set for first pitch at 6:45 p.m. ET on Tuesday, April 21, with the Yankees returning a 1.85x payout if they win, via PrizePicks.
Both teams will deploy young starting pitchers. The Yankees are rolling with SP Luis Gil (0-1, 7.00 ERA), who has struggled since winning the 2024 AL Rookie of the Year award. The Red Sox will opt for SP Connelly Early (1-0, 2.29 ERA), who's making just his ninth career start.
Below, we’ll break down our Yankees vs. Red Sox prediction and picks for Tuesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
Make your picks for Yankees vs. Red Sox on PrizePicks now.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Yankees vs. Red Sox Prediction, Winner Payout, Over/Under – Tuesday, April 21
The Yankees sit atop the AL East with a 13-9 record, while the Red Sox are in a tie for last at 9-13. The Yankees have slugged their way to a winning mark, hitting the third-most home runs (32) in baseball. That's been an area of weakness for the Red Sox, who are tied for the fewest homers (13).
The Red Sox’s inability to hit home runs could provide a boost for Gil. He was taken deep three times in his last start against the Los Angeles Angels and has given up 4 home runs across just 9 innings this season.
Yankees vs. Red Sox Winner Payout, Over/Under – Tuesday, April 21
The Yankees enter Tuesday’s game as a slight road favorite against the Red Sox, returning a 1.85x payout if they win outright, via PrizePicks Team Picks
Here are the full payouts for the Yankees vs. Red Sox game on PrizePicks.
- Spread: New York Yankees -1.5 (2.38x payout)
- Over/Under: 8.5 runs (1.92x payout Over)
- Game Winner Payout: Yankees 1.85x | Red Sox 1.88x
Play the Yankees vs. Red Sox winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live as of writing and is subject to change.
Yankees vs. Red Sox Prediction on Winner – 4/21/26
Here are the key game stats and trends behind our Yankees vs. Red Sox prediction on the winner for Tuesday, April 21.
Lock in your Yankees vs. Red Sox prediction on PrizePicks before the line moves.
- Red Sox SP Sonny Gray (hamstring) only logged 2.2 innings in Monday’s 8-6 win over the Detroit Tigers. That forced Boston to use seven different relief pitchers. However, none of them logged more than 29 pitches, so their bullpen may not face many limitations on Tuesday.
- Although Boston was just 41-40 on the road last season, they went 48-33 at home.
- The Yankees were 4-9 against the Red Sox in 2025.
- Early generally does a good job of keeping hitters inside the ballpark. Last season, he allowed 5 home runs over 100.1 innings in the minors. In his brief time in the majors, he's given up only 1 homer over 39 innings.
- The Yankees' bullpen has struggled mightily, in large part due to the unit’s 1.44 WHIP. Meanwhile, the Red Sox’s bullpen has a 1.21 WHIP.
Yankees vs. Red Sox Player Picks, Stats for PrizePicks: 4/21/26
Here are top Yankees vs. Red Sox picks to target on PrizePicks for Tuesday, April 21. Today's MLB picks for PrizePicks include OF Jarren Duran and SP Luis Gil.
Red Sox OF Jarren Duran vs. Yankees Projection: 5.5 Hitter Fantasy Score
- Duran is only batting .164, but he still has 12 runs scored and 10 RBIs across 17 games.
- The lefty-hitting outfielder may be getting unlucky, given his .222 BABIP. Per FanGraphs, he has a career .336 BABIP.
- Duran recorded a .376 wOBA and a .228 ISO at Fenway Park last season, compared to a .297 wOBA and a .146 ISO on the road.
- Gil’s bloated 7.00 ERA is backed by a 6.44 xERA. In addition to allowing a lot of home runs, he has a 12.2% walk rate. That comes on the heels of his 13.5% walk rate last season.
Add Jarren Duren to your PrizePicks Lineup now.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Yankees SP Luis Gil vs. Red Sox Projection: 4.5 Strikeouts
- Gil had a 26.8% strikeout rate in 2024. That dropped to 16.8% last season. Over his 9 innings this year, he has just 7 strikeouts.
- With Gil issuing so many walks, he generally doesn’t pitch deep into games. Over his 13 starts since the beginning of 2025, he's lasted more than 5 innings just six times.
- In his lone start against the Red Sox last year, the righty hurler posted 3 strikeouts to go along with 5 walks over 5 innings.
- If Gil struggles again, the Yankees could go to their bullpen early because they're well rested after a day off. The team has already shown a quick hook with Gil, having him throw 88 and 83 pitches in his two outings.
Add Luis Gil to your PrizePicks Lineup now.
Make Yankees vs. Red Sox Picks on PrizePicks
One of the best rivalries in baseball gets underway Tuesday with the Red Sox hosting the Yankees. The Red Sox have a favorable matchup against Gil, who isn’t missing many bats lately. His struggles could result in a big night at the plate for Duran, who thrived at home last season.
Don’t wait until the first pitch — make your Yankees vs. Red Sox picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.
