White Sox vs. Yankees Prediction, MLB Picks for Tuesday, June 16

The Chicago White Sox vs. New York Yankees game is slated to get underway at 7:05 p.m. ET on Tuesday, June 16, with the Yankees returning a 1.66x payout if they come out on top, per PrizePicks.

The Yankees are fresh off taking two games of a three-game series against the Toronto Blue Jays. Meanwhile, the White Sox also had an eventful weekend as they were victorious in two of their three contests against the Los Angeles Dodgers.

Below, we'll break down our White Sox vs. Yankees prediction and picks for Tuesday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.

Make your White Sox vs. Yankees picks on PrizePicks now.

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White Sox vs. Yankees Prediction, Winner Payout, Over/Under – Tuesday, June 16

In Tuesday’s series opener, Yankees SP Gerrit Cole (4.57 xFIP across 22.0 innings) and White Sox SP Davis Martin (3.15 xFIP in 78.1 innings) will face off on the mound.

Cole made his season debut in late May after missing the entire 2025 campaign due to Tommy John surgery. Since returning to the mound, the Yankees' starter has yielded 2 or fewer runs in three of his four outings and has a 2.81 xERA.

On the other hand, Martin leads the White Sox in wins (9), ERA (2.41), and strikeouts (79). The right-hander has allowed 1 or fewer runs in four of his last six starts.

The White Sox and Yankees have been two of the more dangerous lineups throughout the majors in 2026. According to FanGraphs, the Yankees rank second in wRC+ (113), while the White Sox come in ninth with a wRC+ of 105.

White Sox vs. Yankees Winner Payout, Over/Under – Tuesday, June 16

The Yankees enter Tuesday's game as a home favorite against the White Sox, returning a 1.66x payout if they win outright via PrizePicks Team Picks.

Here are the full payouts for the White Sox vs. Yankees game on PrizePicks.

• Spread: New York Yankees -1.5 (2.38x payout)
• Over/Under: 7.5 (1.81x payout on Over)
• Game Winner Payout: White Sox 2.12x | Yankees 1.66x

Play the White Sox vs. Yankees winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Yankees vs. White Sox Prediction on Winner – 6/16/26

Here are the key game stats and trends behind our White Sox vs. Yankees prediction on the winner for Tuesday, June 16.

Lock in your White Sox vs. Yankees prediction on PrizePicks now.

• The Yankees are 8-1 in their last nine meetings against the White Sox, including going 3-0 at home during that span.
• According to Baseball Savant, Cole has held opposing hitters to a .209 xBA, which ranks in the 83rd percentile.
• Despite coming off Tommy John, the Yankees’ ace has tallied a 96.7 mph fastball velocity, also sitting in the 83rd percentile.
• The Yankees lead the majors in home runs (102) while scoring the sixth-most runs (358).
• Martin has recorded a 3.80 xERA in 13 starts (57th percentile).
• Martin has surrendered at least 4 earned runs in two of his last four starts and has a 4.61 ERA in three career starting appearances vs. the Yankees.

White Sox vs. Yankees Picks, Player Stats for PrizePicks: 6/16/26

Here are the top White Sox vs. Yankees picks to target on Tuesday, June 16. Today’s MLB picks for PrizePicks include SP Gerrit Cole and 2B Chase Meidroth.

Yankees SP Gerrit Cole vs. White Sox: 5.5 Strikeouts

• Cole has registered 5 or fewer strikeouts in three of his four starts.
• Cole has a 20.2% K-rate in 2026, residing in just the 35th percentile among MLB pitchers.
• The Yankees’ right-hander has tossed 5.1 innings or fewer in each of his last two outings.
• Cole has tallied 4 total strikeouts across two home starts since returning to the mound.

Add Gerrit Cole to your PrizePicks Lineup now.

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White Sox 2B Chase Meidroth vs. Yankees: 5 Hitter Fantasy Score

• Meidroth is hitting .333 (14-of-42) in June, including slugging a home run and recording 7 RBI.
• The White Sox second baseman has tallied a home run and 4 RBI across his last three games.
• Chicago's infielder has just a 22.1% strikeout rate, which ranks in the 43rd percentile.
• Meidroth has also scored at least a run in three of his last six contests.

Add Chase Meidroth to your PrizePicks Lineup now.

Make White Sox vs. Yankees Picks on PrizePicks

The Yankees have been on a tear with a 6-1 record across their last seven games. Can they continue their stellar play against a talented White Sox team on Tuesday?

Don’t wait until the first pitch — make your White Sox vs. Yankees picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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