BYU appears to be on a mission.
After just missing out on the Big 12 championship game last season, the Cougars have won their first four games, and are doing it with freshman sensation QB Bear Bachmeier, who has 10 total TDs in four games. They take on West Virginia, who is 0-2 to start conference play.
Also on Friday's college football slate, South Florida hosts Charlotte, as USF QB Byrum Brown leads his squad to its first AAC matchup of the season. And San Diego State and Colorado State open their Mountain West schedule with a battle in Snapdragon Stadium.
Below are PrizePicks' CFB DFS picks for Friday night's five-game college football slate for Week 6.
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Week 6 CFB DFS Picks for Friday, 10/3
Here are the top Friday CFB DFS picks for CFB Week 6 on PrizePicks, including BYU vs. West Virginia, and New Mexico vs. San Jose State
BYU QB Bear Bachmeier Projection: 244.5 Pass+Rush Yards
BYU vs. West Virginia Pick – 10:30 p.m. ET
Bear Bachmeier had a great game today. My favorite throw was this rifle to Chase in a tight window. Anticipation. Arm strength. Confidence. 🔥 pic.twitter.com/wLoN5bnAPs
— BoozeCougs (@BoozeCougs) September 21, 2025
- BYU QB Bear Bachmeier has more than 244 pass+rush yards in two consecutive games.
- Bachmeier's 1.8% turnover-worthy play rate ranks 31st in the FBS.
- West Virginia is 62nd in takeaways (1.3),and land at 97th in total yards allowed per game (424.5).
- In West Virginia’s Week 5 loss to Utah, they allowed dual-threat QB Devon Dampier to throw for 237 yards and rush for 33.
San Jose State QB Walker Eget Projection: 288.5 Passing Yards
New Mexico vs. San Jose State Pick – 10 p.m. ET
SJSU quarterback Walker Eget completed a career-high 36 passes for a career-high 473 yards and three touchdowns at Stanford.
— Emily Van Buskirk (@Emilnem) September 29, 2025
The 473 passing yards are the most for an FBS quarterback in a game this season and would've been the third most in FBS last season.
- In a Week 5 win over Stanford, San Jose State QB Walker Eget threw for a career-high 473 yards.
- San Jose has the highest pass-play percentage in the FBS (69.01%).
- New Mexico is 129th in opponents' pass play percentage (57.58%).
- Eget is 15th in pass attempts (164).
- The Lobos rank 100th in pass attempts allowed (34.3), and 57th in defensive pass EPA (-0.06).
South Florida QB Byrum Brown Projection: 243.5 Passing Yards
Charlotte vs. South Florida Pick – 7 p.m. ET
BYRUM BROWN 42-YARD TD PASS FOR THE TL 🤲😮💨
— USF Football (@USFFootball) September 20, 2025
📺: @ESPNPlus pic.twitter.com/6vxZOPS6el
- South Florida QB Byrum Brown has topped 244 passing yards in two of his last three games.
- The senior is 37th in average yards per dropback (7.74).
- Charlotte ranks 100th in defensive pass EPA (0.15).
- Brown recently threw for 274 yards against a Miami pass defense that sits 46th in defensive pass EPA (-0.004).
Colorado State RB Jalen Dupree Projection: 63.5 Rushing Yards
Colorado State vs. San Diego State Pick – 10:30 p.m. ET
My 5-year-old and I do coloring pages every night during cuddle time — often AI generated ones he comes up with the prompt for. Tonight I scribbled a quick Jalen Dupree image. #CSURams pic.twitter.com/W0MJLAFEpZ
— Matt L. Stephens (@MattStephens) September 14, 2025
- Colorado State RB Jalen Dupree has rushed for less than 63 yards in two of his last three games.
- San Diego State has given up less than 70 total rushing yards in two of four outings, and have allowed just one running back to rush for more than 60 yards.
- Dupree is 146th in college football in rushing success rate (43.4%).
- The Aztecs stand 10th in defensive rushing success rate (29.3%).
New Mexico WR Dorian Thomas Projection: 56.5 Receiving Yards
New Mexico vs. San Jose State Pick – 10 p.m. ET
Dorian Thomas is having himself a DAY🔥
— Mountain West (@MountainWest) September 6, 2025
📺 MWN/MW App pic.twitter.com/bX9O9TZVzH
- New Mexico WR Dorian Thomas leads the team in catches (24), receiving yards (247), and receiving TDs (3).
- Thomas has more than 70 receiving yards in two of four games this season.
- According to PFF, Thomas’ 91.5% route participation rate is the second-highest among tight ends with at least 17 targets.
- San Jose State has let a tight end be its opponent’s second-leading receiver and score a TD in two of their four games.
Make Friday College Football Picks on PrizePicks
Friday night brings us five exciting college football games, including a Big 12 matchup between West Virginia and BYU. Another conference matchup pits AAC rivals Charlotte as they travel to Tampa, FL to take on South Florida.
No matter what your Friday college football picks are, there's no better way to cash in than with PrizePicks' real money CFB DFS game.
Just pick More or Less on player stat projections and get paid when your picks are correct — all the way up to 2000x your entry fee.
Check out the Playbook for more CFB DFS picks and college football predictions throughout the season!
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