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The Minnesota Vikings and Chicago Bears will clash in an NFC North showdown in Week 2 on Sunday, September 20, at 1:00 p.m. ET on FOX. With both teams coming off Week 1 wins, the Bears are 4.5-point home favorites, with a 1.42x payout to win on PrizePicks entering Sunday’s game.
Ahead of kickoff, the Vikings have ruled out QB Kyler Murray due to being in the league’s concussion protocol. In Murray’s absence, QB Carson Wentz is expected to start.
Below, we’ll break down our Vikings vs. Bears prediction and picks for Sunday’s NFL game, including the spread, over/under, and PrizePicks player projections for Week 2.
Make your Vikings vs. Bears picks on PrizePicks now!
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Vikings vs. Bears Prediction, Spread, Over/Under – Sunday, September 20
It was a quick debut for Murray, who exited in the first quarter of the Vikings’ season opener against the Green Bay Packers. Wentz would enter the game in relief and help lead Minnesota to a 39-22 victory after facing a 22-10 deficit.
Besides Brian Flores’ defense characteristically making life difficult for the Packers’ offense, it was a positive sign to see WR Justin Jefferson produce 8 catches for 92 yards and 2 TDs in the win.
Along with Murray being sidelined, RB Jordan Mason was placed on injured reserve with a thumb injury. Mason tallied 59 rushing yards and a TD on 15 carries in Week 1.
Scoring was not an issue for the Bears in Week 1, as they put up 59 points against the Carolina Panthers. QB Caleb Williams contributed 334 total yards and 4 TDs, while RB D’Andre Swift also had 124 rushing yards and 3 TDs.
On the defensive side of the ball, Chicago left a lot to be desired, allowing 37 points and 478 total yards to Carolina’s offense. The unit will certainly need to perform better to avoid falling to a division rival in Week 2.
Entering Week 2, Williams is tied with QB Lamar Jackson for the second-lowest payout to win NFL MVP (6.66x) on PrizePicks. The Bears have the lowest payout to win the NFC North (2.5x), followed by the Vikings with the third-lowest payout (4.34x).
Vikings vs. Bears Spread, Over/Under – Sunday, September 20
The Bears enter Sunday’s game as 4.5-point favorites against the Vikings, returning a 1.42x payout on PrizePicks if they win outright.
Here are the full payouts for Vikings vs. Bears.
Make your Vikings vs. Bears prediction on the over/under on PrizePicks!
PrizePicks data is live at the time of writing and is subject to change.
Vikings vs. Bears Prediction on Over/Under – 9/20/26
Here are the key stats and trends behind our Vikings vs. Bears prediction on the over/under for Sunday, September 20.
- Wentz made five starts for the Vikings in 2025, and the over was achieved in all five of those games.
- In the final three quarters of its win against Green Bay, Minnesota had the sixth-best EPA/play (0.2), per RBSDM.
- Among the 32 QBs with 25 or more plays in Week 1, Wentz had the seventh-best adjusted EPA/play (0.4).
- En route to their lopsided win over the Panthers, the Bears’ offense had the third-best EPA/play (0.4) and fourth-highest success rate (53.3%).
- Williams earned the third-best adjusted EPA/play (0.5), third-highest success rate (65.1%), and second-best completion percentage over expected (+16.6%) of the QBs who had 25 or more plays in the opening week.
- On top of the Bears’ defense permitting the fourth-most yards per play (7.7) in Week 1, the Vikings’ defense allowed the sixth-most yards per play (6.3), per Team Rankings.
Vikings vs. Bears Picks, Player Stats for PrizePicks: 9/20/26
Here are the top Vikings vs. Bears picks to target on Sunday, September 20. Today’s NFL picks for PrizePicks include RB Aaron Jones, WR Luther Burden III, and QB Caleb Williams.
Vikings RB Aaron Jones vs. Bears: 61.5 Rush Yards
- With Mason inactive for the Vikings, Jones should handle the majority of the backfield workload.
- Jones has rushed for at least 70 yards in three of his last four meetings against the Bears.
- Since the start of last season, Chicago’s defense is 21st in rushing EPA (-0.0) and 29th in rushing success rate (44.1%) allowed.
Add Aaron Jones to your PrizePicks lineup now.
Bears WR Luther Burden III vs. Vikings: 51.5 Receiving Yards
- Although Burden didn’t have as explosive a performance in a 59-point outing for the Bears, he still had 63 yards on 5 catches.
- The Vikings ran zone coverage at the fourth-highest rate (88.1%) in the opening week of the season, and Burden led the Bears in receiving yards (485) and yards per route run (3.2) against zone in 2025, per PFF.
- Burden has tallied at least 67 receiving yards in four of his last five regular-season games.
- Among WRs with 50 or more targets last season, Burden had the third-most yards after the catch per reception (7.3) and third-most yards per route run (2.7).
Add Luther Burden III to your PrizePicks lineup now.
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Bears QB Caleb Williams vs. Vikings: 19.5 Pass Completions
- Williams has completed 20 or more passes in five straight starts (including the playoffs).
- Against the Panthers in Week 1, Williams completed 21 of his 29 attempts.
- Considering that the Vikings often blitz with Flores at defensive coordinator, Williams and the Bears’ offense can lean on quick throws and completions.
Add Caleb Williams to your PrizePicks lineup now.
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The Vikings and Bears both came away with wins in high-scoring affairs in Week 1. Points should continue to be a common theme for both Minnesota and Chicago in Week 2.
Don't wait until kickoff — make your Vikings vs. Bears picks on PrizePicks now for Week 2 and earn real money if you're right.
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