Tonight at Daikin Park in Houston, USA vs. Brazil in the World Baseball Classic begins each team's campaign with a pool-play matchup that starts at 8 p.m. ET on FOX.
The United States' roster is widely considered the best in the 2026 WBC field, while our experts rank Brazil as the 19th out of 20 rosters. That's led America to be massive 9.5-run favorites in their debut WBC game.
Let’s look at a USA vs. Brazil prediction and WBC picks for Friday, March 6. Make your WBC picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, run lines, and totals.
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USA vs. Brazil Prediction, Run Line, Over/Under
The United States has participated in the last two WBC Championship Games, winning one, and is considered a favorite because its roster features the most MLB talent.
Team Brazil, meanwhile, has been absent from the WBC for a long time and is back in the tournament for the first time in over a decade.
USA vs. Brazil Winner, Run Line, Over/Under
USA enters this WBC matchup as a 9.5-run favorite, returning a 1.63x payout on PrizePicks Team Picks if they cover the massive run line.
Team Brazil is a heavy underdog with 22.22x payout if they win their 2026 WBC debut outright, via PrizePicks Team Picks, where you can earn money with your picks in 34 states.
- Run Line: USA -9.5 (1.63x payout)
- Over/Under: 13.5
- Game Winner Payout: USA N/A | Brazil 22.22x
Team Picks data is live at the time of writing and is subject to change.
USA vs. Brazil Prediction on Run Line for 2026 WBC
Here are the key stats to know before locking in your USA vs. Brazil prediction on the run line for Friday, March 6 on PrizePicks.
USA Preview vs. Brazil for 2026 WBC
- Team USA is the lone roster that consists of only current MLB players.
- A whopping 22 of the 30 players on the United States roster are former MLB All-Stars. Team USA also features multiple players with international experience, as seven have previously won gold medals.
- Three current or former MVPs are on the club: New York Yankees OF Aaron Judge, Philadelphia Phillies 1B Bryce Harper, and Yankees 1B Paul Goldschmidt.
- This is Judge’s first time playing in the World Baseball Classic, and he comes into this tournament red hot. In Team USA’s two warm-up games against the San Francisco Giants and Colorado Rockies, the reigning MVP went 3-for-5 with a home run.
- Giants P Logan Webb will start for the United States and is coming off a year in which he tied a career-high 15 wins and led the National League with 244 strikeouts.
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Brazil Preview vs. USA for 2026 WBC
- This is the first time Team Brazil has qualified for the World Baseball Classic since 2013.
- The Brazilian baseball team secured its spot in the WBC by winning a qualifying tournament in March 2025.
- Team Brazil didn't win any games in their only WBC appearance in 2013.
- This squad has eight players signed with MLB organizations. However, no player on the roster has appeared in an MLB regular-season or playoff game yet.
Make USA vs. Brazil Picks in WBC on PrizePicks
The 2026 WBC is an opportunity for the world's best baseball players to represent their country in a tournament. Keep the WBC schedule handy as you lock in for this year's tournament, including the USA getting started on Friday night vs. Brazil.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states.
Stick around with the Playbook for continued WBC predictions, picks, and news.
