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Top MLB NRFI & YRFI Picks Tonight – Wednesday, June 25

Rays SP Drew Rasmussen takes the mound vs. the Royals tonight. The Rays vs. Royals game sets up a great YRFI / NRFI pick today, including on PrizePicks MLB.
AP Photo/Chris O'Meara

A beautiful 15-game Wednesday MLB slate with most teams throwing some of their best pitchers presents us with tons of opportunities to target in the first inning with No Run First Inning (NRFI) or Yes Run First inning (YRFI) picks.

Below, we’ll analyze two NRFI or YRFI picks to consider for MLB on Wednesday, June 25.

In addition to stats like home runs, hits, and pitcher strikeouts, there are also 1st Inning Runs Allowed projections to consider on PrizePicks MLB. This is one way to get real money action on No Run First Inning (NRFI) or Yes Run First Inning (YRFI) picks and get action in the first frame of MLB games.

Be sure to head to the PrizePicks MLB board, lock in your predictions, and submit your Lineup to get in on the real money MLB action before the first pitch. 

Get started on PrizePicks today to get $50 free after your first $5 Lineup.

Yankees vs. Reds – 7:10 p.m.

Max Fried vs. Brady Singer – 0.5 1st Inning Runs Allowed

MLB NRFI Picks Today - Yankees vs. Reds

Max Fried continues to cement his reputation as a first‐frame shutdown artist, posting a 12-4 NRFI record this season with six of those shutdown innings coming at home. Facing batters for the first time through the order, Fried has surrendered only 25 hits in 132 at‐bats for a minuscule .189 average. 

Opposite him for the Reds will be newly acquired Brady Singer, who enters his debut campaign in Cincinnati at 11-4 to NRFI, including a proficient 6-1 NRFI record on the road. When facing batters the first time through the order Singer has allowed a .250 average in 120 at bats, though his toughest task comes against Aaron Judge, who owns five hits in thirteen career plate appearances against him.

The Yankees, meanwhile, have gone 6-4 to NRFI in their last ten games, scoring a first-inning run in four out of the last 10 games.

Rays vs. Royals – 7:40 p.m.

Drew Rasmussen + Michael Wacha – 0.5 1st Inning Runs Allowed

MLB NRFI Picks Today - Rays vs. Royals

Drew Rasmussen has been one of the best first‐inning pitchers in the Rays rotation, owning a 12-3 NRFI record this season and an even more impressive 15-4 NRFI record since last year. Rassmussen will square off against two of Kansas City’s most feared bats — Salvador Pérez and Vinnie Pasquantino — whom he’s combined to limit to just two hits in a combined 12 career at-bats. At home, the Royals have not scored in the first inning in 30 or 39 games.

On the rubber for the Royals is Michael Wacha, who brings a perfect 15-0 to NRFI this year. He's pitched 19 scoreless first innings in 22 starts at home since 2024. A first inning matchup for Wacha to watch will be against Brandon Lowe who has just one hit in 10 career at-bats. When facing batters the first time through the order, Wacha has allowed a .240 batting average this season.

Make YRFI / NRFI Picks on PrizePicks

With a 15-game slate on Wednesday in the MLB, now is the time to get in on the YRFI & NRFI action on PrizePicks.

Just build your MLB Lineup on PrizePicks with your MLB predictions and win real money if your picks are correct. All you have to do is pick More or Less on at least two player projections — like hits or pitcher strikeouts — to win.

There’s always real money MLB action waiting for you on PrizePicks. Stay locked in on the Playbook all season long for MLB player picks every day,

Get in the Game! Sign up for PrizePicks and win real money with your picks. Play $5 to get $50 free with promo code PLAYBOOK.

about the author

Shayne Trail is a Penn State Smeal College of Business graduate, and is the President of the @HallofFameFund (on X) where he positions historically profitable sports trends into investments. Shayne has expertise in all major sports, but writes mostly about NFL, MLB, and NBA for Playbook.

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