A beautiful 15-game Wednesday MLB slate with most teams throwing some of their best pitchers presents us with tons of opportunities to target in the first inning with No Run First Inning (NRFI) or Yes Run First inning (YRFI) picks.
Below, we’ll analyze two NRFI or YRFI picks to consider for MLB on Wednesday, June 25.
In addition to stats like home runs, hits, and pitcher strikeouts, there are also 1st Inning Runs Allowed projections to consider on PrizePicks MLB. This is one way to get real money action on No Run First Inning (NRFI) or Yes Run First Inning (YRFI) picks and get action in the first frame of MLB games.
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Yankees vs. Reds – 7:10 p.m.
Max Fried vs. Brady Singer – 0.5 1st Inning Runs Allowed

Max Fried continues to cement his reputation as a first‐frame shutdown artist, posting a 12-4 NRFI record this season with six of those shutdown innings coming at home. Facing batters for the first time through the order, Fried has surrendered only 25 hits in 132 at‐bats for a minuscule .189 average.
Opposite him for the Reds will be newly acquired Brady Singer, who enters his debut campaign in Cincinnati at 11-4 to NRFI, including a proficient 6-1 NRFI record on the road. When facing batters the first time through the order Singer has allowed a .250 average in 120 at bats, though his toughest task comes against Aaron Judge, who owns five hits in thirteen career plate appearances against him.
The Yankees, meanwhile, have gone 6-4 to NRFI in their last ten games, scoring a first-inning run in four out of the last 10 games.
Rays vs. Royals – 7:40 p.m.
Drew Rasmussen + Michael Wacha – 0.5 1st Inning Runs Allowed

Drew Rasmussen has been one of the best first‐inning pitchers in the Rays rotation, owning a 12-3 NRFI record this season and an even more impressive 15-4 NRFI record since last year. Rassmussen will square off against two of Kansas City’s most feared bats — Salvador Pérez and Vinnie Pasquantino — whom he’s combined to limit to just two hits in a combined 12 career at-bats. At home, the Royals have not scored in the first inning in 30 or 39 games.
On the rubber for the Royals is Michael Wacha, who brings a perfect 15-0 to NRFI this year. He's pitched 19 scoreless first innings in 22 starts at home since 2024. A first inning matchup for Wacha to watch will be against Brandon Lowe who has just one hit in 10 career at-bats. When facing batters the first time through the order, Wacha has allowed a .240 batting average this season.
Make YRFI / NRFI Picks on PrizePicks
With a 15-game slate on Wednesday in the MLB, now is the time to get in on the YRFI & NRFI action on PrizePicks.
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