Top MLB Home Run Picks Today on PrizePicks – Wednesday, May 27

Each and every MLB team is scheduled to play on Wednesday, setting the scene for plenty of potential highlights. Home runs figure to be in the mix, which naturally leads to wondering which stars could swat a ball out of the yard. 

Here at PrizePicks, we have plenty of home run projections on the board to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.

Let’s dive into some of the most-picked MLB home run projections for Wednesday, May 27, including what makes each player a potential target for home run predictions. 

Make your MLB home run picks for Wednesday, May 27 on PrizePicks now.  

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Top Home Run Picks Today – Wednesday, May 27

For as easy as players make hitting home runs look, they’re anything but that. It takes more than just strength to get a ball past the warning track, over the fences, and into the crowd for a game-changing sequence.

First and foremost, how hard did a player hit the baseball? Where on the bat did the ball connect? What was the speed of the swing? How about launch angle? That doesn’t even account for weather, outfield dimensions, or anything else.

A home run is never just a home run, as some players tend to put themselves in better positions for success than others.   

Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. With that said, home runs can only be selected as “More” than 0.5. 

Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at time of writing.

1. Phillies DH Kyle Schwarber
2. Angels CF Mike Trout
3. Yankees OF Aaron Judge
4. Dodgers DH Shohei Ohtani
5. Cardinals RF Jordan Walker
6. Mariners CF Julio Rodriguez
7. Diamondbacks 2B Ketel Marte
8. Guardians 3B Jose Ramirez

Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

Mariners CF Julio Rodriguez

Mariners vs. Athletics – 3:05 p.m. ET

Athletics Starting Pitcher: Jeffrey Springs

MLB Weather Report: 68 degrees, mostly clear skies, 4 mph south wind

• After lacking in the power department in the months of March and April, Rodriguez is heating up big-time. In May, he has a .531 SLG and a .265 ISO.
• J-Rod has maintained the same 76.4 mph bat speed as 2025 while raising his fast-swing percentage from 63.9% to 65.2%. 
• The star outfielder owns a .447 xSLG, which sits in the 72nd percentile leaguewide. 
• Springs has already surrendered 11 homers on the year, putting his HR/9 at an alarming 1.61. 
• According to Ballpark Pal, Wednesday’s weather conditions have a combined effect of +24% regarding home run park factor. 

Add Julio Rodriguez to your PrizePicks Lineup now.

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Angels CF Mike Trout

Angels vs. Tigers – 6:40 p.m. ET

Tigers Starting Pitcher: Casey Mize

MLB Weather Report: 78 degrees, clear skies, 9 mph northeast wind

• Trout has turned back the clock in a major way this season. His 145 wRC+ and .384 wOBA are his highest marks since 2022, when he racked up 6.0 fWAR in just 119 games.
• At the age of 34, Trout has a 20.1% barrel rate that’s a personal best for him since the stat was first tracked back in 2015.
• The multi-time AL MVP could be due for positive regression in the power department, as his .578 SLG is nearly 100 points higher than his .479 SLG.
• Trout sits in the 88th percentile for bat speed (75.2 mph) and the 86th percentile for hard-hit rate (48.5%).
• Mize has enjoyed an excellent season, but he might have one weakness that plays into Trout’s wheelhouse. He’s surrendering a 25.9% pull-air percentage; Trout’s mark at the plate is 22.0%. 

Add Mike Trout to your PrizePicks Lineup now.

Dodgers DH Shohei Ohtani

Rockies vs. Dodgers – 10:10 p.m. ET

Rockies Starting Pitcher: Tomoyuki Sugano

MLB Weather Report: 62 degrees, clear skies, 10 mph southwest wind

• Despite a bit of an underwhelming start in the batter’s box, Ohtani is coming around. Additionally, the gap between his SLG (.471) and xSLG (.523) is 52 points.
• Year-over-year, the phenom’s squared-up contact share is actually up 1.1%. 
• Ohtani is hitting line drives with 3.1% greater frequency than last year, which could come to his aid if he raises his fly ball percentage (37.9% is his lowest since 2020). 
• Sugano is in the 10th percentile in hard-hit rate (46.6%) and the first percentile in barrel rate (16.3%). 
• Opponents are slugging .587 against Sugano’s fastballs with a .692 xSLG. Ohtani has respective marks of .528 and .636 against the offering in 2026.

Add Shohei Ohtani to your PrizePicks Lineup now.

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The stars are in full force throughout the day on Wednesday, with seemingly countless high-profile names heading out to the ballpark. Might the trio of Rodriguez, Trout, and Ohtani get the crowd going with a home run? 

Don’t wait until first pitch — make your MLB home run picks on PrizePicks now and earn real money if you’re right.

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