On Wednesday, MLB returns with a 15-game slate that features all 30 teams in action. Reds SS Elly De La Cruz is just one hitter that's worth keeping an eye on.
PrizePicks offers daily home run projections for all your MLB picks, and many hitters have already been targeted by users as some of the most popular home run picks in Wednesday’s slate.
Below, we’ll break down the most-picked MLB home run predictions for Wednesday, including each player’s matchup, recent production, and what makes them a popular home run pick.
Make your MLB home run picks for Wednesday, April 29, on PrizePicks now.
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Top Home Runs Picks Today – Wednesday, April 29
Hitting a home run is one of the toughest achievements that a player can complete. As a result, it makes it extraordinarily difficult to predict which players can go yard daily.
Several significant factors can be attributed to a player’s likelihood of launching the ball over the fence. How hard has a player been hitting the baseball? Has the opposing starting pitcher been surrendering a ton of fly balls? Could weather conditions play a role?
Home run projections are labeled as Demons on PrizePicks, which comes with a higher payout. However, you can only choose “More” on home run projections, normally set at 0.5.
Here’s a look at the most popular home run picks for today on PrizePicks.
- Yankees OF Aaron Judge
- Astros OF Yordan Alvarez
- White Sox 1B Munetaka Murakami
- Angels OF Mike Trout
- Dodgers DH Shohei Ohtani
- Mariners C Cal Raleigh
- Phillies DH Kyle Schwarber
- Guardians 3B Jose Ramirez
- Reds SS Elly De La Cruz
- Blue Jays 1B Vladimir Guerrero Jr.
Below, we’ll break down three matchups for today, including the opposing starting pitcher with advanced stats from FanGraphs and Baseball Savant, capped by a weather report via RotoGrinders.
Reds SS Elly De La Cruz
Colorado Rockies vs. Cincinnati Reds – 6:40 p.m. ET
Rockies Starting Pitcher: Tomoyuki Sugano (5 GS, 2-1, 4.22 xFIP, 46.4% hard-hit, 40.5% FB%)
MLB Weather Report: 61 degrees, clear skies, and 10 mph winds out to CF
- De La Cruz has slugged at least 22 home runs in two of his first three professional seasons and already has 10 to his credit in 2026.
- The star infielder has registered a 32.3% home run-to-fly ball rate, which is the highest of his career.
- The Reds SS has recorded a 16.9% barrel rate, ranking in the 93rd percentile.
- De La Cruz has tallied a career-best 38.8% fly ball rate, outperforming his previous personal record of 33.0% from 2024. Meanwhile, Sugano surrenders an alarming 40.5% fly ball rate.
- Sugano has given up 5 home runs across five starts, which breaks down to a 1.71 HR/9 and a 14.7% HR/FB.
- De La Cruz has slugged 5 of his 10 home runs against right-handed pitchers.
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Yankees OF Aaron Judge
New York Yankees vs. Texas Rangers – 2:35 p.m. ET
Rangers Starting Pitcher: Nathan Eovaldi (6 GS, 2-4, 3.62 xFIP, 49.5% hard-hit, 33.3% FB%)
MLB Weather Report: Played in a dome
- Judge has belted 12 home runs thus far in 2026, including one in three consecutive contests.
- The Judge has registered a 26.1% barrel rate, which ranks in the 100th percentile.
- The Yankees' MVP slugger has tallied a 34.3% home run-to-fly ball rate, which ranks among the highest of his career.
- Judge has also recorded a .677 xSLG (99th percentile), 55.1% hard-hit rate (94th), and a 93.2 average exit velocity (91st).
- Eovaldi has surrendered 9 home runs across his six starts, good for a 2.48 HR/9 and a 25.7% HR/FB rate.
- Judge has mashed 7 of his 12 home runs against right-handed pitching.
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Blue Jays 1B Vladimir Guerrero Jr.
Boston Red Sox vs. Toronto Blue Jays – 3:07 p.m. ET
Red Sox Starting Pitcher: Brayan Bello (5 GS, 1-3, 5.23 xFIP, 40.2% hard-hit, 30.6% FB%)
MLB Weather Report: Played in a dome
- Guerrero has clobbered at least 30 home runs in three of his past five seasons.
- He may own just a 7.7% home run-to-fly ball rate this season, but Guerrero averages a 17.5% mark in his eight-year career.
- The Blue Jays’ 1B has a .499 xSLG (84th percentile), 93.0 average exit velocity (90th), and 76.3 mph average bat speed (96th).
- Guerrero has averaged a 33.1% fly ball rate in his MLB tenure, and Bello is surrendering a 30.6% fly ball rate (second-highest of his career).
- Bello has coughed up 8 home runs, breaking down to a 3.27 HR/9 and a career-worst 30.8% HR/FB rate.
- While Guerrero only has 2 home runs, he did belt 17 of his 23 homers against righties in 2025.
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Elly De La Cruz and Aaron Judge could benefit from favorable pitching matchups on Wednesday, while Vladimir Guerrero Jr. looks to get back on track in the home run department. Who will go yard on Wednesday, April 29?
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