After an action-packed Friday night of baseball, all of MLB is back in action this weekend as Saturday’s slate takes shape. There’s stars galore taking the field from the afternoon through evening, which could lead to some tape-measure home runs being sent out of the yard.
Here at PrizePicks, we have plenty of home run projections on the board to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.
Let’s dive into some of the most-picked MLB home run projections for Saturday, May 16, including what makes each player a potential target for home run predictions.
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Top Home Run Picks Today – Saturday, May 16
Nothing gets a crowd — or a team, for that matter — going like a nice home run. Whenever a player can muster the strength and benefit from the right set of circumstances to club a homer, it can flip a game’s win probability in a major way.
With that said, simply hitting the ball hard isn’t the only thing that must be done. Elements like launch angle, barrel quality, pitch type, weather conditions, ballpark dimensions, and more can decide whether a home run is turned into an out, extra-base hit, or jack.
Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. With that said, home runs can only be selected as “More” than 0.5.
Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at time of writing.
- Cardinals RF Jordan Walker
- Phillies DH Kyle Schwarber
- Royals SS Bobby Witt Jr.
- Blue Jays 3B Kazuma Okamoto
- Astros DH Yordan Alvarez
- Twins CF Byron Buxton
- Pirates CF Oneil Cruz
- Reds SS Elly De La Cruz
Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.
Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.
Cardinals RF Jordan Walker
Royals vs. Cardinals – 2:15 p.m. ET
Royals Starting Pitcher: Noah Cameron
MLB Weather Report: 79 degrees, 35% chance of precipitation, 10 mph southwest wind
- Cardinals RF Jordan Walker is finally delivering on the hype for St. Louis, posting career-highs in ISO (.291), SLG (.594), and wRC+ (173).
- The 23-year-old outfielder has nearly doubled his barrel rate from 2025, going from 10.9% to 18.3%.
- Walker has an 83.9% fast swing rate in 2026, well above his MLB career average of 72.1%.
- Royals SP Noah Cameron ranks in the 23rd percentile in average exit velocity, and it gets even worse for hard-hit rate (15th percentile) and barrel rate (fifth percentile).
- Cameron is allowing 7.3% more line drives and 6.1% more fly balls this year than last.
Add Jordan Walker to your PrizePicks Lineup now.
Royals SS Bobby Witt Jr.
Royals vs. Cardinals – 2:15 p.m. ET
Cardinals Starting Pitcher: Kyle Leahy
MLB Weather Report: 79 degrees, 35% chance of precipitation, 10 mph southwest wind
- Royals SS Bobby Witt Jr. is on fire in the month of May, seeing significant increases in SLG (+.237), ISO (+.176), and wOBA (+.116) over March and April.
- Witt owns a new personal best in both hard-hit rate (53.1%) and line drive rate (22.1%).
- The veteran infielder is in the 92nd percentile or better in xSLG (.534), hard-hit clip, and average exit velocity (93.5 mph).
- After surrendering 0.74 HR/9 in 2024 and 0.51 in 2025, SP Kyle Leahy’s way up to 1.36 in eight starts this year.
- Leahy sits in the eighth percentile in average exit velocity (91.5 mph) and the fourth percentile in hard-hit clip (51.2%).
Add Bobby Witt Jr. to your PrizePicks Lineup now.
Blue Jays 3B Kazuma Okamoto
Blue Jays vs. Tigers – 1:10 p.m. ET
Tigers Starting Pitcher: Casey Mize
MLB Weather Report: 75 degrees, 16% chance of precipitation, 12 mph southwest wind
- Blue Jays 3B Kazuma Okamoto’s rookie year is off to a roaring start, seeing him club 10 home runs with a .220 ISO and .459 SLG.
- The former NPB standout could be in for some positive regression, as evidenced by his .499 xSLG and .286 BABIP.
- Okamoto taps into his power more against righties than lefties; there’s a .076 gap in SLG and a .136 space in ISO between the two splits.
- The 29-year-old is in the 90th percentile or better in barrel rate (15.7%), average exit velocity (93.1 mph), and hard-hit percentage (53.7%).
- Mize has turned things around in his age-29 campaign, although he’s still below the 40th percentile in both barrel (8.6%) and hard-hit (42.0%) rates.
Add Kazuma Okamoto to your PrizePicks Lineup now.
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Make MLB Home Run Picks on PrizePicks
After going yard on Friday night against the Royals, can Jordan Walker replicate that success on Saturday? On the other side of the matchup, could Bobby Witt Jr. stay hot and deliver in the I-70 rivalry? Those players are just two of the many daily home run picks to choose from.
Don’t wait until first pitch today — make your MLB home run picks on PrizePicks now and earn real money if you’re right.
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