Top MLB Home Run Picks Today on PrizePicks – Monday, June 22

Another new week, another big-time slate of MLB games to choose from. Twenty-six of the league’s 30 teams play on Monday evening and into the night, presenting the opportunity for double-digit home runs to be hit. 

Here at PrizePicks, we have plenty of home run projections on the board to add to your MLB picks today. Many hitters have already been singled out by users as popular home run picks for the day’s action.

Let’s dive into some of the most-picked MLB home run projections for Monday, June 22, including what makes each player a potential target for home run predictions. 

Make your MLB home run picks for Monday, June 22 on PrizePicks now.  

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Top Home Run Picks Today – Monday, June 22

It’s one thing for a player to have the raw strength to hit a home run. It’s another to possess the right blend of baseball acumen, timing, good fortune, and more to actually make it happen.

In the age of advanced analytics, the baseball world knows plenty about what truly goes into a homer. Bat speed, launch angle, barrel rate, pitcher dynamics, ballpark dimensions, and weather all play a role in deciding whether a ball leaves the yard or not. That makes predicting home runs an imperfect science, but some circumstances present better conditions than others. 

Daily home run projections are listed as Demons on PrizePicks, coming with higher payouts as a result. With that said, home runs can only be selected as “More” than 0.5. 

Let’s take a look at the most popular home run picks today on PrizePicks. Picks are listed at time of writing.

1. Cubs CF Pete Crow-Armstrong
2. Twins CF Byron Buxton
3. Royals RF Jac Caglianone
4. Yankees 1B Ben Rice
5. Tigers C Dillon Dingler
6. Dodgers DH Shohei Ohtani
7. Cardinals 1B Alec Burleson
8. Phillies DH Kyle Schwarber

Three home run picks stand out as potential targets today. Let’s dive into the list, including a weather report from RotoGrinders.

Unless otherwise noted, data used in this article is from Baseball Savant or FanGraphs.

Cubs CF Pete Crow-Armstrong

Cubs vs. Mets – 7:10 p.m. ET 

Mets Starting Pitcher: Kodai Senga

MLB Weather Report: 73 degrees, 79% chance of rain, 13 mph south-southeast wind

• The PCA breakout is officially here. The fourth-year man owns career-best marks for ISO (.234, tied), SLG (.521), and wRC+ (145). 
• After a strong May, the month of June has been otherworldly for Crow-Armstrong. Thus far, he’s got a video game-like SLG (.930) and ISO (.493) with a staggering 281 wRC+.
• Crow-Armstrong is making louder contact than ever, as he’s increased his hard-hit rate each year. After a 14.6% jump from 2023 to 2024 and a 4.8% spike from 2024 to 2025, he’s up 9.6% year-over-year.
• Swinging the bat with more authority has also been a key. Crow-Armstrong’s raised his average bat speed by 2.2 mph while seeing his fast swing rate skyrocket from 28.5% to 50.6%.
• Senga has been hit around this season, sitting in just the second percentile in ground ball clip (27.9%) and the ninth percentile in chase rate (24.8%). 

Add Pete Crow-Armstrong to your PrizePicks Lineup now.

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Twins CF Byron Buxton

Dodgers vs. Twins – 7:40 p.m. ET

Dodgers Starting Pitcher: Eric Lauer

MLB Weather Report: 77 degrees, clear skies, 5 mph northeast wind

• Buxton’s power is shining through in a massive way this season, as evidenced by his .315 ISO and a whopping .591 SLG. The lifetime Twin has 24 home runs already through just 67 games.
• A key improvement for Buxton is his barrel rate, which has been in the double digits every year since 2020 but is peaking at 18.5% right now.
• The 32-year-old resides in the 98th percentile with that barrel rate, as well as the 91st percentile in xSLG (.517). 
• Lauer is struggling immensely with the home run ball, surrendering 2.45 HR/9.
• The 31-year-old L.A. starter is in the 10th percentile or worse in barrel rate (10th), whiff rate (10th), and fastball velocity (fifth). 

Add Byron Buxton to your PrizePicks Lineup now.

Cardinals 1B Alec Burleson

Diamondbacks vs. Cardinals – 7:45 p.m. ET

Diamondbacks Starting Pitcher: Merrill Kelly

MLB Weather Report: 76 degrees, clear skies, 6 mph north wind

• Burleson’s age-27 campaign has been his best, seeing him achieve an ISO of .200 or better for the first time while also posting a career-high 10.9% barrel rate.
• After a multi-year dip, Burleson’s 48.6% hard-hit percentage is right in line with his 48.7% mark from 2022 when he had just 39 batted ball events.
• The Cardinals’ veteran star is thriving at tapping into his directional power, boasting a 19.8% pull rate on fly balls.
• Some positive regression could be in store for Burleson, as his .554 xSLG sits in the 96th percentile.
• Kelly is ceding a career-worst 1.94 HR/9 and ranks in just the first percentile in barrel rate with an alarming 15.3% mark. 

Add Alec Burleson to your PrizePicks Lineup now.

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While there are plenty of stars taking the field in Monday’s MLB slate, the trio of Crow-Armstrong, Buxton, and Burleson could be in solid position to club a ball out of the park given their blend of matchup and recent performance. 

Don’t wait until first pitch — make your MLB home run picks on PrizePicks now and earn real money if you’re right.

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