Top MLB DFS Picks Today: Best Hitters & Pitchers, 5/16/25

The Friday MLB slate showcases a full slate of 15 games, including interleague rivalry matchups. The Yankees and Mets hook up in the Bronx at 7:05 p.m. ET, while the Cardinals and Royals meet in Kansas City at 7:40 p.m. ET.

Welcome to Friday’s MLB DFS Picks, as we’ll break down Friday’s MLB games and give today’s best MLB DFS picks for PrizePicks for May 16, including pitcher strikeout projections, hitter projections, and a home run pick to target today.

Let’s break down some of the best MLB picks to target for the Friday MLB DFS slate on PrizePicks.

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MLB DFS Picks on PrizePicks: Friday, 5/16

Here are some of the top MLB DFS picks and predictions on PrizePicks today. Use this analysis to help you build a stacked MLB Lineup on PrizePicks for Friday, May 16. Click each pick to read more.

• Brewers P Chad Patrick — 4.5 Strikeouts
• Giants P Logan Webb — 6 Strikeouts
• Blue Jays SS Bo Bichette — 1.5 Total Bases
• Home Run Pick: Mets LF Brandon Nimmo

Brewers P Chad Patrick — 4.5 Strikeouts

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• Brewers P Chad Patrick has finished with four strikeouts or less in five of his past seven starts.
• The Twins have recorded the second-fewest strikeouts among American League teams against opposing starting pitchers.
• In 30-of-44 games this season, starting pitchers facing Minnesota have finished with less than their strikeout projection on PrizePikcs.
• Patrick’s best strikeout performances have come at home this season. He posted five strikeouts or more in three of four outings at American Family Field.
• Two of Minnesota’s top hitters are questionable on Friday as SS Carlos Correa and CF Byron Buxton exited Thursday’s win at Baltimore following a collision – both are in concussion protocol but haven’t been ruled out yet.

Giants P Logan Webb — 6 Strikeouts

• Giants P Logan Webb has compiled six strikeouts or more in five consecutive starts.
• In seven of the past eight starts, Webb has struck out six batters or more, including a pair of double-digit strikeout outings.
• The Athletics have struck out at least six times in five of the last seven contests against opposing starting pitchers.
• In eight of the last 10 home games, San Francisco starting pitchers have recorded six or fewer strikeouts.
• Nine Athletics hitters have posted six hits in 39 at-bats against Webb, including six strikeouts.

Blue Jays SS Bo Bichette — 1.5 Total Bases

• Blue Jays SS Bo Bichette leads the team with 53 hits, including 14 doubles. 
• Bichette has picked up multiple hits in four of the past six games. In Thursday’s loss to the Rays, Bichette recorded his first three-hit game since April 12.
• In seven career at-bats against Tigers P Jack Flaherty, Bichette owns three hits. Two of those hits came in a 9-1 road victory last May.
• Flaherty has struggled recently as he allowed 14 runs in his past three starts. In his last outing against Texas, the right-hander gave up four hits, all home runs.

Home Run Pick: Mets LF Brandon Nimmo

• Mets LF Brandon Nimmo enters tonight’s game against the Yankees with eight home runs on the season.
• Seven of Nimmo’s eight homers have come on the road, while three have been hit off left-handers — Yankees SP Carlos Rodón is a lefty.
• Nimmo has not homered against Rodón in four at-bats.
• Rodón has given up eight home runs this season with three of them getting hit by left-handers. Last season, only three of Rodón’s 31 homers allowed came against lefties.
• The forecast in New York calls for light wind blowing out to left field today.

Note: Demon picks increase your payout on PrizePicks, as they are harder projections to hit.

Make MLB DFS Picks, Win Cash on PrizePicks

There’s exciting action on Friday’s MLB slate as every team takes the diamond to start the weekend. With 15 MLB games on tonight, now is time to build your MLB Lineup on PrizePicks.

Just pick More or Less at least two MLB player stat projections to build your Lineup on PrizePicks. Use the players above to build your Lineups around, or use a 6-Pick Lineup to reach up to 2000x payouts.

Check out the Playbook for more MLB DFS picks and analysis all the way through the season.